MicroRNAs in myocardial ischemia: identifying new targets and tools for treating heart disease. New frontiers for miR-medicine

MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKIIδ

(2013) Min-Ji Cha et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Small Solutions to Big Problems

(2013) Deepak Srivastava et al.   CIRCULATION RESEARCH

mir-17–92 Cluster Is Required for and Sufficient to Induce Cardiomyocyte Proliferation in Postnatal and Adult Hearts

(2013) Jinghai Chen et al.   CIRCULATION RESEARCH

microRNAs in cardiac development and regeneration

(2013) Enzo R. Porrello   CLINICAL SCIENCE

MicroRNA Regulation and Role in Stem Cell Maintenance, Cardiac Differentiation and Hypertrophy

(2013) K.T. Kuppusamy et al.   CURRENT MOLECULAR MEDICINE

MicroRNA regulation of endothelial homeostasis and commitment—implications for vascular regeneration strategies using stem cell therapies

(2013) Elizabeth Scott et al.   FREE RADICAL BIOLOGY AND MEDICINE

microRNA-1 enhances the angiogenic differentiation of human cardiomyocyte progenitor cells

(2013) Alain van Mil et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

MicroRNA-34a regulates cardiac ageing and function

(2013) Reinier A. Boon et al.   NATURE

Identification of Temporal and Region-Specific Myocardial Gene Expression Patterns in Response to Infarction in Swine

(2013) Cristina Prat-Vidal et al.   PLoS One

miR-21 Promotes Fibrogenic Epithelial-to-Mesenchymal Transition of Epicardial Mesothelial Cells Involving Programmed Cell Death 4 and Sprouty-1

(2013) Hasse Brønnum et al.   PLoS One

Expression Profile of microRNAs Regulating Proliferation and Differentiation in Mouse Adult Cardiac Stem Cells

(2013) Luis Brás-Rosário et al.   PLoS One

miRNA-711-SP1-collagen-I pathway is involved in the anti-fibrotic effect of pioglitazone in myocardial infarction

(2013) Na Zhao et al.   Science China-Life Sciences

Therapeutic Cardiac‐Targeted Delivery of miR‐1 Reverses Pressure Overload–Induced Cardiac Hypertrophy and Attenuates Pathological Remodeling

(2013) Ioannis Karakikes et al.   Journal of the American Heart Association

Mesenchymal stem cells overexpressing MiR-126 enhance ischemic angiogenesis via the AKT/ERK-related pathway

(2012) Jian-Jun Chen et al.   Cardiology Journal

MicroRNA-214 inhibits angiogenesis by targeting Quaking and reducing angiogenic growth factor release

(2012) Alain van Mil et al.   CARDIOVASCULAR RESEARCH

MicroRNAs in Stress Signaling and Human Disease

(2012) Joshua T. Mendell et al.   CELL

MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor-β1 Pathway

(2012) Zhenwei Pan et al.   CIRCULATION

Loss of AngiomiR-126 and 130a in Angiogenic Early Outgrowth Cells From Patients With Chronic Heart Failure

(2012) Philipp Jakob et al.   CIRCULATION

A New Level of Complexity

(2012) Thomas Boettger et al.   CIRCULATION RESEARCH

MicroRNAs and Stem Cells

(2012) Eva-Marie Heinrich et al.   CIRCULATION RESEARCH

Regulation of the Inflammatory Response in Cardiac Repair

(2012) Nikolaos G. Frangogiannis   CIRCULATION RESEARCH

Developing MicroRNA Therapeutics

(2012) Eva van Rooij et al.   CIRCULATION RESEARCH

Differential Expression of MicroRNAs in Different Disease States

(2012) Maha Abdellatif   CIRCULATION RESEARCH

Regulation of zebrafish heart regeneration by miR-133

(2012) Viravuth P. Yin et al.   DEVELOPMENTAL BIOLOGY

Early assessment of acute coronary syndromes in the emergency department: the potential diagnostic value of circulating microRNAs

(2012) Martinus I. F. J. Oerlemans et al.   EMBO Molecular Medicine

SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway

(2012) Regalla Kumarswamy et al.   EUROPEAN HEART JOURNAL

A novel reciprocal loop between microRNA-21 and TGFβRIII is involved in cardiac fibrosis

(2012) Haihai Liang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeting cell death in the reperfused heart: Pharmacological approaches for cardioprotection

(2012) Martinus I.F.J. Oerlemans et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The MicroRNA miR-199a-5p Down-regulation Switches on Wound Angiogenesis by Derepressing thev-etsErythroblastosis Virus E26 Oncogene Homolog 1-Matrix Metalloproteinase-1 Pathway

(2012) Yuk Cheung Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Cardiomyocyte-enriched MicroRNA, miR-378, Targets Insulin-like Growth Factor 1 Receptor

(2012) Ivana Knezevic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-24 regulates cardiac fibrosis after myocardial infarction

(2012) Jue Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca2+ overload and cell death

(2012) Arin B. Aurora et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-204 is required for differentiation of human-derived cardiomyocyte progenitor cells

(2012) Junjie Xiao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Stem cell-based delivery of Hypoxamir-210 to the infarcted heart: implications on stem cell survival and preservation of infarcted heart function

(2012) Ha Won Kim et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Functional screening identifies miRNAs inducing cardiac regeneration

(2012) Ana Eulalio et al.   NATURE

Mammalian heart renewal by pre-existing cardiomyocytes

(2012) Samuel E. Senyo et al.   NATURE

Dynamic microRNA expression during the transition from right ventricular hypertrophy to failure

(2012) Sushma Reddy et al.   PHYSIOLOGICAL GENOMICS

MicroRNA-145 Protects Cardiomyocytes against Hydrogen Peroxide (H2O2)-Induced Apoptosis through Targeting the Mitochondria Apoptotic Pathway

(2012) Ruotian Li et al.   PLoS One

Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function

(2012) B. C. Bernardo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family

(2012) E. R. Porrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects

(2011) R. Kannan Mutharasan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes

(2011) Ji Fang et al.   APOPTOSIS

Novel therapy for myocardial infarction: can HGF/Met be beneficial?

(2011) V. Sala et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Novel MicroRNA Prosurvival Cocktail for Improving Engraftment and Function of Cardiac Progenitor Cell Transplantation

(2011) S. Hu et al.   CIRCULATION

MicroRNA-24 Regulates Vascularity After Myocardial Infarction

(2011) Jan Fiedler et al.   CIRCULATION

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID)

(2011) Mariell Jessup et al.   CIRCULATION

Human Cardiac Stem Cell Differentiation Is Regulated by a Mircrine Mechanism

(2011) Toru Hosoda et al.   CIRCULATION

Heart Disease and Stroke Statistics—2012 Update

(2011) et al.   CIRCULATION

miR-15 Family Regulates Postnatal Mitotic Arrest of Cardiomyocytes

(2011) Enzo R. Porrello et al.   CIRCULATION RESEARCH

Inhibition of miR-15 Protects Against Cardiac Ischemic Injury

(2011) Thomas G. Hullinger et al.   CIRCULATION RESEARCH

Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage

(2011) Yasuhide Kuwabara et al.   Circulation-Cardiovascular Genetics

MiR-1 Downregulation Cooperates with MACC1 in Promoting MET Overexpression in Human Colon Cancer

(2011) C. Migliore et al.   CLINICAL CANCER RESEARCH

MicroRNAs in the cardiovascular system

(2011) Mingyue Han et al.   CURRENT OPINION IN CARDIOLOGY

MicroRNAs as Potential Therapeutic Agents in the Treatment of Myocardial Infarction

(2011) Jens Heyn et al.   Current Vascular Pharmacology

MicroRNAs and cardiovascular diseases

(2011) Koh Ono et al.   FEBS Journal

The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes

(2011) C. Xu et al.   JOURNAL OF CELL SCIENCE

miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes

(2011) Li Qian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts

(2011) Padmini Sirish et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

miR-210: The Master Hypoxamir

(2011) YUK C. CHAN et al.   MICROCIRCULATION

MicroRNAs: New Players in Cardiac Injury and Protection

(2011) R. C. Kukreja et al.   MOLECULAR PHARMACOLOGY

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Activated Met Signalling in the Developing Mouse Heart Leads to Cardiac Disease

(2011) Christian Leo et al.   PLoS One

Pre-microRNA and Mature microRNA in Human Mitochondria

(2011) Eric Barrey et al.   PLoS One

Hepatocyte Growth Factor (HGF) Inhibits Collagen I and IV Synthesis in Hepatic Stellate Cells by miRNA-29 Induction

(2011) Monika Kwiecinski et al.   PLoS One

miR-29 Is a Major Regulator of Genes Associated with Pulmonary Fibrosis

(2010) Leah Cushing et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Downregulation of microRNA-29 by antisense inhibitors and a PPAR-γ agonist protects against myocardial ischaemia–reperfusion injury

(2010) Yumei Ye et al.   CARDIOVASCULAR RESEARCH

Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4

(2010) Y. Cheng et al.   CARDIOVASCULAR RESEARCH

MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease

(2010) S. Hu et al.   CIRCULATION

MicroRNAs Add a New Dimension to Cardiovascular Disease

(2010) Eric M. Small et al.   CIRCULATION

MicroRNA-494 Targeting Both Proapoptotic and Antiapoptotic Proteins Protects Against Ischemia/Reperfusion-Induced Cardiac Injury

(2010) Xiaohong Wang et al.   CIRCULATION

MicroRNAs As Circulating Biomarkers for Heart Failure: Questions About MiR-423-5p

(2010) Regalla Kumarswamy et al.   CIRCULATION RESEARCH

MiR423-5p As a Circulating Biomarker for Heart Failure

(2010) Anke J. Tijsen et al.   CIRCULATION RESEARCH

Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease

(2010) Maarten F. Corsten et al.   Circulation-Cardiovascular Genetics

Expression and Function of MicroRNAs in Heart Disease

(2010) Sadakatsu Ikeda et al.   CURRENT DRUG TARGETS

microRNA Regulation as a Therapeutic Strategy for Cardiovascular Disease

(2010) Rusty L. Montgomery et al.   CURRENT DRUG TARGETS

The Roles of MicroRNAs in Heart Diseases: A Novel Important Regulator

(2010) B. Cai et al.   CURRENT MEDICINAL CHEMISTRY

MicroRNA Regulatory Networks in Cardiovascular Development

(2010) Ning Liu et al.   DEVELOPMENTAL CELL

Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans

(2010) Guo-Kun Wang et al.   EUROPEAN HEART JOURNAL

Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice

(2010) David M. Patrick et al.   JOURNAL OF CLINICAL INVESTIGATION

Primary contribution to zebrafish heart regeneration by gata4 + cardiomyocytes

(2010) Kazu Kikuchi et al.   NATURE

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

(2010) Chris Jopling et al.   NATURE

miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1

(2010) Jian-Xun Wang et al.   NATURE MEDICINE

Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression

(2010) Z Chen et al.   ONCOGENE

MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU

(2010) Elena Favaro et al.   PLoS One

miRNAs as Therapeutic Targets in Ischemic Heart Disease

(2010) Robert J. A. Frost et al.   Journal of Cardiovascular Translational Research

Progenitor cells isolated from the human heart: a potential cell source for regenerative therapy

(2010) P. van Vliet et al.   Netherlands Heart Journal

miR-30 Regulates Mitochondrial Fission through Targeting p53 and the Dynamin-Related Protein-1 Pathway

(2010) Jincheng Li et al.   PLoS Genetics

Upregulated expression of miR-1/miR-206 in a rat model of myocardial infarction

(2009) Zhi-Xin Shan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction

(2009) Jing Ai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue

(2009) Sashwati Roy et al.   CARDIOVASCULAR RESEARCH

MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2

(2009) Stephen Y. Chan et al.   Cell Metabolism

Reciprocal Regulation of Myocardial microRNAs and Messenger RNA in Human Cardiomyopathy and Reversal of the microRNA Signature by Biomechanical Support

(2009) Scot J. Matkovich et al.   CIRCULATION

MicroRNA-320 Is Involved in the Regulation of Cardiac Ischemia/Reperfusion Injury by Targeting Heat-Shock Protein 20

(2009) Xiao-Ping Ren et al.   CIRCULATION

Reciprocal Regulation of MicroRNA-1 and Insulin-Like Growth Factor-1 Signal Transduction Cascade in Cardiac and Skeletal Muscle in Physiological and Pathological Conditions

(2009) Leonardo Elia et al.   CIRCULATION

Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes

(2009) Shweta Rane et al.   CIRCULATION RESEARCH

A Family of microRNAs Encoded by Myosin Genes Governs Myosin Expression and Muscle Performance

(2009) Eva van Rooij et al.   DEVELOPMENTAL CELL

MicroRNA-1 Regulates Cardiomyocyte Apoptosis by Targeting Bcl-2

(2009) Yehua Tang et al.   International Heart Journal

Ischemic Preconditioning Augments Survival of Stem Cells via miR-210 Expression by Targeting Caspase-8-associated Protein 2

(2009) Ha Won Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA Expression Signature and the Role of MicroRNA-21 in the Early Phase of Acute Myocardial Infarction

(2009) Shimin Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4

(2009) Yunhui Cheng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MicroRNA-1 Negatively Regulates Expression of the Hypertrophy-Associated Calmodulin and Mef2a Genes

(2009) S. Ikeda et al.   MOLECULAR AND CELLULAR BIOLOGY

microRNA: Emerging therapeutic targets in acute ischemic diseases

(2009) Pasquale Fasanaro et al.   PHARMACOLOGY & THERAPEUTICS

MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice

(2009) A. Bonauer et al.   SCIENCE

Unresolved issues in myocardial reperfusion injury

(2008) Louis Maximilian Buja et al.   CARDIOVASCULAR PATHOLOGY

The Emerging Role of MicroRNAs in Cardiac Remodeling and Heart Failure

(2008) Vijay Divakaran et al.   CIRCULATION RESEARCH

miR-133 and miR-30 Regulate Connective Tissue Growth Factor

(2008) Rudy F. Duisters et al.   CIRCULATION RESEARCH

The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis

(2008) Shusheng Wang et al.   DEVELOPMENTAL CELL

microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart

(2008) N. Liu et al.   GENES & DEVELOPMENT

Adeno-Associated Virus (AAV) Serotype 9 Provides Global Cardiac Gene Transfer Superior to AAV1, AAV6, AAV7, and AAV8 in the Mouse and Rat

(2008) Lawrence T. Bish et al.   HUMAN GENE THERAPY

MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3

(2008) Pasquale Fasanaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch1 signaling stimulates proliferation of immature cardiomyocytes

(2008) Chiara Collesi et al.   JOURNAL OF CELL BIOLOGY

Features of cardiomyocyte proliferation and its potential for cardiac regeneration

(2008) Machteld J. van Amerongen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

miRNA expression in the failing human heart: Functional correlates

(2008) Carmen Sucharov et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MicroRNA-21 Targets Sprouty2 and Promotes Cellular Outgrowths

(2008) Danish Sayed et al.   MOLECULAR BIOLOGY OF THE CELL

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

Stem-cell therapy for cardiac disease

(2008) Vincent F. M. Segers et al.   NATURE

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

(2008) E. van Rooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs flex their muscles

(2008) Eva van Rooij et al.   TRENDS IN GENETICS