Challenging the future of siRNA therapeutics against cancer: the crucial role of nanotechnology

Toll-like Receptor 3 Regulates Angiogenesis and Apoptosis in Prostate Cancer Cell Lines through Hypoxia-Inducible Factor 1α

(2015) Alessio Paone et al.   NEOPLASIA

Dendritic Cells Loaded with Tumor Antigens and a Dual Immunostimulatory and Anti-Interleukin 10-Specific Small Interference RNA Prime T Lymphocytes against Leukemic Cells

(2014) Per O. Iversen et al.   Translational Oncology

Target delivery of MYCN siRNA by folate-nanoliposomes delivery system in a metastatic neuroblastoma model

(2013) Qiqi Zhu et al.   Cancer Cell International

Lipid-Based Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges

(2012) Lígia C. Gomes-da-Silva et al.   ACCOUNTS OF CHEMICAL RESEARCH

Safety profile of RNAi nanomedicines

(2012) Scott A. Barros et al.   ADVANCED DRUG DELIVERY REVIEWS

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Depletion of protein kinase N3 (PKN3) impairs actin and adherens junctions dynamics and attenuates endothelial cell activation

(2012) Kristin Möpert et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment

(2012) Lígia C. Gomes-da-Silva et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Systemic delivery of siRNA nanoparticles targeting RRM2 suppresses head and neck tumor growth

(2012) Mohammad Aminur Rahman et al.   JOURNAL OF CONTROLLED RELEASE

The promotion of siRNA delivery to breast cancer overexpressing epidermal growth factor receptor through anti-EGFR antibody conjugation by immunoliposomes

(2011) Jie Gao et al.   BIOMATERIALS

EGFR-specific PEGylated immunoliposomes for active siRNA delivery in hepatocellular carcinoma

(2011) Jie Gao et al.   BIOMATERIALS

Targeted and intracellular triggered delivery of therapeutics to cancer cells and the tumor microenvironment: impact on the treatment of breast cancer

(2011) Vera Moura et al.   BREAST CANCER RESEARCH AND TREATMENT

Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors

(2011) Dirk Strumberg et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Anti-PEG IgM production by siRNA encapsulated in a PEGylated lipid nanocarrier is dependent on the sequence of the siRNA

(2011) Tatsuaki Tagami et al.   JOURNAL OF CONTROLLED RELEASE

Nanotechnology for therapy and imaging of liver diseases

(2011) L. Harivardhan Reddy et al.   JOURNAL OF HEPATOLOGY

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

A robust in vivo positive-readout system for monitoring siRNA delivery to xenograft tumors

(2011) X. Lin et al.   RNA

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

(2010) Katrin Knop et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Co-encapsulation of anti-BCR-ABL siRNA and imatinib mesylate in transferrin receptor-targeted sterically stabilized liposomes for chronic myeloid leukemia treatment

(2010) Liliana S. Mendonça et al.   BIOTECHNOLOGY AND BIOENGINEERING

Hypoxia inducible factors in cancer stem cells

(2010) J M Heddleston et al.   BRITISH JOURNAL OF CANCER

Dual targeting of EphA2 and FAK in ovarian carcinoma

(2010) Mian M.K. Shahzad et al.   CANCER BIOLOGY & THERAPY

Tumor Site-Specific Silencing of NF- B p65 by Targeted Hollow Gold Nanosphere-Mediated Photothermal Transfection

(2010) W. Lu et al.   CANCER RESEARCH

Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models

(2010) A. Santel et al.   CLINICAL CANCER RESEARCH

Evading tumor evasion: Current concepts and perspectives of anti-angiogenic cancer therapy

(2010) Amir Abdollahi et al.   DRUG RESISTANCE UPDATES

T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes

(2010) Hiroyuki Koide et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

miRNAs in human cancer

(2010) Thalia A Farazi et al.   JOURNAL OF PATHOLOGY

Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

(2010) Thomas W Geisbert et al.   LANCET

Designer Lipids Advance Systemic siRNA Delivery

(2010) Yang Liu et al.   MOLECULAR THERAPY

Nanoparticles Targeted With NGR Motif Deliver c-myc siRNA and Doxorubicin for Anticancer Therapy

(2010) Yunching Chen et al.   MOLECULAR THERAPY

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Silencing of the MYCN gene by siRNA delivered by folate receptor-targeted liposomes in LA-N-5 cells

(2010) Chen Feng et al.   PEDIATRIC SURGERY INTERNATIONAL

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymeric carriers: Preclinical safety and the regulatory implications for design and development of polymer therapeutics

(2009) Rogério Gaspar et al.   ADVANCED DRUG DELIVERY REVIEWS

Design of peptide-targeted liposomes containing nucleic acids

(2009) Adriana O. Santos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Transferrin Receptor-Targeted Liposomes Encapsulating anti-BCR-ABLsiRNA or asODN for Chronic Myeloid Leukemia Treatment

(2009) Liliana S. Mendonça et al.   BIOCONJUGATE CHEMISTRY

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Alternating 2′-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist

(2009) Svetlana Hamm et al.   IMMUNOBIOLOGY

Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice

(2009) Adam D. Judge et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of siRNA in PEG-coated siRNA-lipoplex on anti-PEG IgM production

(2009) Tatsuaki Tagami et al.   JOURNAL OF CONTROLLED RELEASE

The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

(2009) Mark E. Davis   MOLECULAR PHARMACEUTICS

The promises and pitfalls of RNA-interference-based therapeutics

(2009) Daniela Castanotto et al.   NATURE

Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth

(2009) W. G. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Off-target effects of siRNA specific for GFP

(2008) Cordula Tschuch et al.   BMC MOLECULAR BIOLOGY

Atu027, a Liposomal Small Interfering RNA Formulation Targeting Protein Kinase N3, Inhibits Cancer Progression

(2008) M. Aleku et al.   CANCER RESEARCH

Targeted delivery of therapeutics to endothelium

(2008) Eric Simone et al.   CELL AND TISSUE RESEARCH

Chemically modified siRNA: tools and applications

(2008) J WATTS et al.   DRUG DISCOVERY TODAY

Misinterpreting the Therapeutic Effects of Small Interfering RNA Caused by Immune Stimulation

(2008) Marjorie Robbins et al.   HUMAN GENE THERAPY

Overcoming the Innate Immune Response to Small Interfering RNA

(2008) Adam Judge et al.   HUMAN GENE THERAPY

Expression Strategies for Short Hairpin RNA Interference Triggers

(2008) John J. Rossi   HUMAN GENE THERAPY

Non-Viral Lipid-Based Nanoparticles for Targeted Cancer Systemic Gene Silencing

(2008) J. N. Moreira et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Pharmacokinetics and Biodistribution of Nanoparticles

(2008) Shyh-Dar Li et al.   MOLECULAR PHARMACEUTICS

Efficient Oncogene Silencing and Metastasis Inhibition via Systemic Delivery of siRNA

(2008) Shyh-Dar Li et al.   MOLECULAR THERAPY

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE

Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles

(2007) Derek W. Bartlett et al.   BIOTECHNOLOGY AND BIOENGINEERING

Tumor-targeted Delivery of siRNA by Self-assembled Nanoparticles

(2007) Shyh-Dar Li et al.   MOLECULAR THERAPY