Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 70, Issue 24, Pages 4759-4770Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-013-1419-9
Keywords
GPR43; Short-chain fatty acids; Muscle; Adipogenesis; Obesity
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Funding
- National Heart Foundation of Australia [PB 10 M 5472]
- Australian Government's Collaborative Research Networks (CRN) program
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GPR43 is a receptor for short-chain fatty acids. Preliminary data suggest a putative role for GPR43 in regulating systemic health via processes including inflammation, carcinogenesis, gastrointestinal function, and adipogenesis. GPR43 is involved in secretion of gastrointestinal peptides, which regulate appetite and gastrointestinal motility. This suggests GPR43 may have a role in weight control. Moreover, GPR43 regulates plasma lipid profile and inflammatory processes, which further indicates that GPR43 could have the ability to modulate the etiology and pathogenesis of metabolic diseases such as obesity, type 2 diabetes mellitus, and cardiovascular disease. This review summarizes the current evidence regarding the ability of GPR43 to mediate both systemic and tissue specific functions and how GPR43 may be modulated in the treatment of metabolic disease.
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