The therapeutic potential of GPR43: a novel role in modulating metabolic health

Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications

(2013) Theodore Kelesidis   ANNALS OF INTERNAL MEDICINE

Defining the Molecular Basis for the First Potent and Selective Orthosteric Agonists of the FFA2 Free Fatty Acid Receptor

(2013) Brian D. Hudson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human 5-HT4 receptor stimulation in atria of transgenic mice

(2013) Ulrich Gergs et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

GPR43/FFA2: physiopathological relevance and therapeutic prospects

(2013) Laure B. Bindels et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

One-Month Serotonin Infusion Results in a Prolonged Fall in Blood Pressure in the Deoxycorticosterone Acetate (DOCA) Salt Hypertensive Rat

(2012) Robert Patrick Davis et al.   ACS Chemical Neuroscience

Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine

(2012) Nicole de Wit et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Gut microbiota-derived propionate reduces cancer cell proliferation in the liver

(2012) L B Bindels et al.   BRITISH JOURNAL OF CANCER

Glucagon-Like Peptide 1 Recruits Microvasculature and Increases Glucose Use in Muscle via a Nitric Oxide-Dependent Mechanism

(2012) W. Chai et al.   DIABETES

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

(2012) Brian D. Hudson et al.   FASEB JOURNAL

Short-Chain Fatty Acids Suppress Lipopolysaccharide-Induced Production of Nitric Oxide and Proinflammatory Cytokines Through Inhibition of NF-κB Pathway in RAW264.7 Cells

(2012) Tengfei Liu et al.   INFLAMMATION

Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3

(2012) Brian D. Hudson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receptor-specific regulation of ERK1/2 activation by members of the “free fatty acid receptor” family

(2012) Sandra Seljeset et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

(2011) Charlotte J. Green et al.   BIOCHEMICAL JOURNAL

Mitochondrial dysfunction in diabetic cardiomyopathy

(2011) Jennifer G. Duncan   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Diet-induced Obesity Up-regulates the Abundance of GPR43 and GPR120 in a Tissue Specific Manner

(2011) Lauren M. Cornall et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Globalization of Diabetes: The role of diet, lifestyle, and genes

(2011) F. B. Hu   DIABETES CARE

Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists

(2011) Johannes Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunopathogenèse des maladies inflammatoires chroniques de l’intestin

(2011) Julien Matricon   M S-MEDECINE SCIENCES

Extracellular Loop 2 of the Free Fatty Acid Receptor 2 Mediates Allosterism of a Phenylacetamide Ago-Allosteric Modulator

(2011) N. J. Smith et al.   MOLECULAR PHARMACOLOGY

SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor

(2011) Marco A. R. Vinolo et al.   PLoS One

Regulation of inflammatory responses by the commensal microbiota: Figure 1

(2011) Benjamin J Marsland   THORAX

Regulation of Inflammation by Short Chain Fatty Acids

(2011) Marco A.R. Vinolo et al.   Nutrients

Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet

(2010) Mikael Bjursell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice

(2010) Mark W. Hamrick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure

(2010) Que Liu et al.   Cardiovascular Diabetology

Intramyocellular lipid accumulation is associated with permanent relocation ex vivo and in vitro of fatty acid translocase (FAT)/CD36 in obese patients

(2010) C. Aguer et al.   DIABETOLOGIA

Allosteric rescuing of loss-of-function FFAR2 mutations

(2010) Gayathri Swaminath et al.   FEBS LETTERS

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

(2010) Mohamed S. Zaibi et al.   FEBS LETTERS

G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer

(2010) Yong Tang et al.   INTERNATIONAL JOURNAL OF CANCER

Density distribution of free fatty acid receptor 2 (FFA2)-expressing and GLP-1-producing enteroendocrine L cells in human and rat lower intestine, and increased cell numbers after ingestion of fructo-oligosaccharide

(2010) Izumi Kaji et al.   JOURNAL OF MOLECULAR HISTOLOGY

Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice

(2010) Evelyne M. Dewulf et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Adipokine Profile and Insulin Sensitivity in Formerly Obese Women Subjected to Bariatric Surgery or Diet-Induced Long-term Caloric Restriction

(2010) M. C. Mitterberger et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Leptin increases skeletal muscle lipoprotein lipase and postprandial lipid metabolism in mice

(2010) William T. Donahoo et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Propionate-induced epithelial K+ and Cl−/HCO 3 − secretion and free fatty acid receptor 2 (FFA2, GPR43) expression in the guinea pig distal colon

(2010) Shin-ichiro Karaki et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Obesity and leptin resistance: distinguishing cause from effect

(2010) Martin G. Myers et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status

(2009) John Andree Babraj et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators

(2009) Yingcai Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of transforming activity of free fatty acid receptor 2 by retroviral expression screening

(2009) Hisashi Hatanaka et al.   CANCER SCIENCE

G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation

(2009) C. Sina et al.   JOURNAL OF IMMUNOLOGY

Central leptin action improves skeletal muscle AKT, AMPK, and PGC1α activation by hypothalamic PI3K-dependent mechanism

(2009) Erika A.F.R. Roman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice

(2009) Neira Sáinz et al.   PLoS One

GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors

(2009) Kashan Ahmed et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Short-chain fatty acids act as antiinflammatory mediatorsby regulating prostaglandin E2 and cytokines

(2009) Mary Ann Cox et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents

(2008) June Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Fatty Acid Binding Receptors and Their Physiological Role in Type 2 Diabetes

(2008) Gayathri Swaminath   ARCHIV DER PHARMAZIE

Chronic leptin treatment stimulates lipid oxidation in immortalized and primary mouse skeletal muscle cells

(2008) Yunike Akasaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Leptin Regulates Peripheral Lipid Metabolism Primarily through Central Effects on Food Intake

(2008) Xavier Prieur et al.   ENDOCRINOLOGY

Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids

(2008) Hongfei Ge et al.   ENDOCRINOLOGY

Conserved Polar Residues in Transmembrane Domains V, VI, and VII of Free Fatty Acid Receptor 2 and Free Fatty Acid Receptor 3 Are Required for the Binding and Function of Short Chain Fatty Acids

(2008) Leigh A. Stoddart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin and its association with insulin resistance and type 2 diabetes

(2008) Tianxin Sheng et al.   Journal of Genetics and Genomics

Effects of olanzapine on glucose transport, proliferation and survival in C2C12 myoblasts

(2008) Giovanni Tulipano et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2

(2008) T. Lee et al.   MOLECULAR PHARMACOLOGY

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Adiponectin Improves Cardiomyocyte Contractile Function indb/dbDiabetic Obese Mice

(2008) Feng Dong et al.   Obesity

Gastrointestinal peptides controlling body weight homeostasis

(2007) Hugo Mendieta-Zerón et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY