Genetic dissection of dendritic cell homeostasis and function: lessons from cell type-specific gene ablation

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Advantages and limitations of mouse models to deplete dendritic cells

(2013) Janneke van Blijswijk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Signals via the Adaptor MyD88 in B Cells and DCs Make Distinct and Synergistic Contributions to Immune Activation and Tissue Damage in Lupus

(2013) Lino L. Teichmann et al.   IMMUNITY

Dendritic Cell Expression of the Signaling Molecule TRAF6 Is Critical for Gut Microbiota-Dependent Immune Tolerance

(2013) Daehee Han et al.   IMMUNITY

Distinct Roles for Neutrophils and Dendritic Cells in Inflammation and Autoimmunity in motheaten Mice

(2013) Clare L. Abram et al.   IMMUNITY

IRF4 Transcription-Factor-Dependent CD103+CD11b+ Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation

(2013) Emma K. Persson et al.   IMMUNITY

Interferon-β Production via Dectin-1-Syk-IRF5 Signaling in Dendritic Cells Is Crucial for Immunity to C. albicans

(2013) Carlos del Fresno et al.   IMMUNITY

The Cytokines IL-21 and GM-CSF Have Opposing Regulatory Roles in the Apoptosis of Conventional Dendritic Cells

(2013) Chi-Keung Wan et al.   IMMUNITY

Control of T Helper 2 Responses by Transcription Factor IRF4-Dependent Dendritic Cells

(2013) Yan Gao et al.   IMMUNITY

IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

(2013) Andreas Schlitzer et al.   IMMUNITY

Spleen Tyrosine Kinase (Syk)-dependent Calcium Signals Mediate Efficient CpG-induced Exocytosis of Tumor Necrosis Factor α (TNFα) in Innate Immune Cells

(2013) Sheila Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of T Cell Fates and Immune Tolerance by p38  Signaling in Mucosal CD103+ Dendritic Cells

(2013) G. Huang et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: ABIN-1 Protects against Psoriasis by Restricting MyD88 Signals in Dendritic Cells

(2013) J. A. Callahan et al.   JOURNAL OF IMMUNOLOGY

Critical Role of Dendritic Cell-Derived IL-27 in Antitumor Immunity through Regulating the Recruitment and Activation of NK and NKT Cells

(2013) J. Wei et al.   JOURNAL OF IMMUNOLOGY

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses

(2013) Bryan D Bell et al.   NATURE IMMUNOLOGY

The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells

(2013) Dominique Gatto et al.   NATURE IMMUNOLOGY

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

(2013) Ansuman T Satpathy et al.   NATURE IMMUNOLOGY

Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation

(2013) C. Lamagna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Langerinneg conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice

(2013) C. Wohn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides

(2013) L. Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Commensal Microbiota Are Required for Systemic Inflammation Triggered by Necrotic Dendritic Cells

(2013) Jennifer A. Young et al.   Cell Reports

Loss of the TGFβ-Activating Integrin αvβ8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity

(2013) John J. Worthington et al.   PLoS Pathogens

Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function

(2012) B. Kellersch et al.   BLOOD

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

High susceptibility to liver injury in IL-27 p28 conditional knockout mice involves intrinsic interferon-γ dysregulation of CD4+T cells

(2012) Song Zhang et al.   HEPATOLOGY

Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells

(2012) Nir Yogev et al.   IMMUNITY

B Cell-Intrinsic MyD88 Signaling Prevents the Lethal Dissemination of Commensal Bacteria during Colonic Damage

(2012) Donna Kirkland et al.   IMMUNITY

Dendritic cells tolerized with adenosine A2AR agonist attenuate acute kidney injury

(2012) Li Li et al.   JOURNAL OF CLINICAL INVESTIGATION

MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice

(2012) Magali Noval Rivas et al.   JOURNAL OF CLINICAL INVESTIGATION

The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice

(2012) Salvador Iborra et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage

(2012) Matthew M. Meredith et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

(2012) Monique A.M. Willart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dendritic Cell-Specific Ablation of the Protein Tyrosine Phosphatase Shp1 Promotes Th1 Cell Differentiation and Induces Autoimmunity

(2012) T. Kaneko et al.   JOURNAL OF IMMUNOLOGY

Rho-Family GTPase Cdc42 Controls Migration of Langerhans Cells In Vivo

(2012) N. Luckashenak et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cell-Specific Disruption of TGF-  Receptor II Leads to Altered Regulatory T Cell Phenotype and Spontaneous Multiorgan Autoimmunity

(2012) R. Ramalingam et al.   JOURNAL OF IMMUNOLOGY

Fc  Receptor IIb Strongly Regulates Fc  Receptor-Facilitated T Cell Activation by Dendritic Cells

(2012) N. van Montfoort et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: mTORC1 in Intestinal CD11c+CD11b+ Dendritic Cells Regulates Intestinal Homeostasis by Promoting IL-10 Production

(2012) M. Ohtani et al.   JOURNAL OF IMMUNOLOGY

Distinct APCs Explain the Cytokine Bias of  -Galactosylceramide Variants In Vivo

(2012) L. Bai et al.   JOURNAL OF IMMUNOLOGY

From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

(2012) Jacques Banchereau et al.   NATURE IMMUNOLOGY

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

(2012) Gonghua Huang et al.   NATURE IMMUNOLOGY

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

(2012) Makoto Kudo et al.   NATURE MEDICINE

Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice

(2012) André P Tittel et al.   NATURE METHODS

Autocrine/paracrine TGF- 1 inhibits Langerhans cell migration

(2012) A. Bobr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infected CD8 - dendritic cells are the predominant source of IL-10 during establishment of persistent viral infection

(2012) C. T. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice

(2012) Namiko Hoshi et al.   Nature Communications

Dendritic Cell-Mediated Vaccination Relies on Interleukin-4 Receptor Signaling to Avoid Tissue Damage after Leishmania major Infection of BALB/c Mice

(2012) Anita Masic et al.   PLoS Neglected Tropical Diseases

Depletion of Dendritic Cells Enhances Innate Anti-Bacterial Host Defense through Modulation of Phagocyte Homeostasis

(2012) Stella E. Autenrieth et al.   PLoS Pathogens

Conditional Stat1 Ablation Reveals the Importance of Interferon Signaling for Immunity to Listeria monocytogenes Infection

(2012) Elisabeth Kernbauer et al.   PLoS Pathogens

Critical role for perforin and Fas-dependent killing of dendritic cells in the control of inflammation

(2011) M. Chen et al.   BLOOD

The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor   signaling

(2011) C. Seillet et al.   BLOOD

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Lymphotoxin Controls the IL-22 Protection Pathway in Gut Innate Lymphoid Cells during Mucosal Pathogen Challenge

(2011) Alexei V. Tumanov et al.   Cell Host & Microbe

An essential role for TAK1 in the contact hypersensitivity response

(2011) Yan G Zhao et al.   Cellular & Molecular Immunology

Signaling by the Phosphatase MKP-1 in Dendritic Cells Imprints Distinct Effector and Regulatory T Cell Fates

(2011) Gonghua Huang et al.   IMMUNITY

An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma

(2011) Mirjam Kool et al.   IMMUNITY

Lymph Node T Cell Homeostasis Relies on Steady State Homing of Dendritic Cells

(2011) Meike Wendland et al.   IMMUNITY

Notch2 Receptor Signaling Controls Functional Differentiation of Dendritic Cells in the Spleen and Intestine

(2011) Kanako L. Lewis et al.   IMMUNITY

Tolerogenic function of Blimp-1 in dendritic cells

(2011) Sun Jung Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation

(2011) Seth T. Scanlon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

(2011) Mark S. Diamond et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sirtuin 1 Promotes Th2 Responses and Airway Allergy by Repressing Peroxisome Proliferator-Activated Receptor-  Activity in Dendritic Cells

(2011) A. Legutko et al.   JOURNAL OF IMMUNOLOGY

Immune Regulation through Mitochondrion-Dependent Dendritic Cell Death Induced by T Regulatory Cells

(2011) M. Chen et al.   JOURNAL OF IMMUNOLOGY

Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes

(2011) Ping Xie et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+

(2011) Zachary Gerhart-Hines et al.   MOLECULAR CELL

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis

(2011) Gianna Elena Hammer et al.   NATURE IMMUNOLOGY

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

Cytosolic RIG-I–like helicases act as negative regulators of sterile inflammation in the CNS

(2011) Angela Dann et al.   NATURE NEUROSCIENCE

Mammalian Target of Rapamycin Controls Dendritic Cell Development Downstream of Flt3 Ligand Signaling

(2010) Taheri Sathaliyawala et al.   IMMUNITY

In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells

(2010) Heung Kyu Lee et al.   IMMUNITY

Origin and development of dendritic cells

(2010) Kang Liu et al.   IMMUNOLOGICAL REVIEWS

Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice

(2010) Andrew C. Melton et al.   JOURNAL OF CLINICAL INVESTIGATION

αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice

(2010) Mridu Acharya et al.   JOURNAL OF CLINICAL INVESTIGATION

Calcineurin regulates innate antifungal immunity in neutrophils

(2010) Matthew B. Greenblatt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dendritic Cell (DC)-Specific Targeting Reveals Stat3 as a Negative Regulator of DC Function

(2010) Jessica A. Melillo et al.   JOURNAL OF IMMUNOLOGY

TGF-  Is Required To Maintain the Pool of Immature Langerhans Cells in the Epidermis

(2010) J. M. Kel et al.   JOURNAL OF IMMUNOLOGY

Route of Antigen Uptake Differentially Impacts Presentation by Dendritic Cells and Activated Monocytes

(2010) A. O. Kamphorst et al.   JOURNAL OF IMMUNOLOGY

Therapeutic Targeting of Syk in Autoimmune Diabetes

(2010) L. Colonna et al.   JOURNAL OF IMMUNOLOGY

Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors

(2010) B. Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Activation of  -Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

(2010) S. Manicassamy et al.   SCIENCE

Macrophage- and Dendritic-Cell-Derived Interleukin-15 Receptor Alpha Supports Homeostasis of Distinct CD8+ T Cell Subsets

(2009) Erwan Mortier et al.   IMMUNITY

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

(2009) Guillaume Darrasse-Jèze et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

(2009) Caspar Ohnmacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lack of Conventional Dendritic Cells Is Compatible with Normal Development and T Cell Homeostasis, but Causes Myeloid Proliferative Syndrome

(2008) Tal Birnberg et al.   IMMUNITY

Mechanisms and Consequences of Dendritic Cell Migration

(2008) David Alvarez et al.   IMMUNITY

Cdc42-mTOR Signaling Pathway Controls Hes5 and Pax6 Expression in Retinoic Acid-dependent Neural Differentiation

(2008) Makoto Endo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clearance of influenza virus from the lung depends on migratory langerin+CD11b−but not plasmacytoid dendritic cells

(2008) Corine H. GeurtsvanKessel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

(2008) Shigeru Oshima et al.   NATURE

Migration of Dendritic Cell Subsets and their Precursors

(2007) Gwendalyn J. Randolph et al.   Annual Review of Immunology