Robustness of signal transduction pathways

Selumetinib (AZD6244; ARRY-142886) in the treatment of metastatic melanoma

(2012) Sapna P Patel et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Negative feedback confers mutational robustness in yeast transcription factor regulation

(2012) C. M. Denby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robustness portraits of diverse biological networks conserved despite order-of-magnitude parameter uncertainty

(2011) Anthony R. Soltis et al.   BIOINFORMATICS

Total ERK1/2 activity regulates cell proliferation

(2011) Renaud Lefloch et al.   CELL CYCLE

Systems control of BMP morphogen flow in vertebrate embryos

(2011) Jean-Louis Plouhinec et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Scaling of morphogen gradients

(2011) Danny Ben-Zvi et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells

(2011) Alexander Loewer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Robust Control of Nitrogen Assimilation by a Bifunctional Enzyme in E. coli

(2011) Yuval Hart et al.   MOLECULAR CELL

A Two-Dimensional ERK-AKT Signaling Code for an NGF-Triggered Cell-Fate Decision

(2011) Jia-Yun Chen et al.   MOLECULAR CELL

Stimulus-dependent dynamics of p53 in single cells

(2011) E. Batchelor et al.   Molecular Systems Biology

Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range

(2011) J. Bachmann et al.   Molecular Systems Biology

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling

(2011) R. Fritsche-Guenther et al.   Molecular Systems Biology

Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template

(2011) L. Bleris et al.   Molecular Systems Biology

Feedback regulation of EGFR signalling: decision making by early and delayed loops

(2011) Roi Avraham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development

(2011) M. Paulsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Information Transduction Capacity of Noisy Biochemical Signaling Networks

(2011) R. Cheong et al.   SCIENCE

Robust Signal Processing in Living Cells

(2011) Ralf Steuer et al.   PLoS Computational Biology

SnapShot: Network Motifs

(2010) Oren Shoval et al.   CELL

Systematic Quantification of Negative Feedback Mechanisms in the Extracellular Signal-regulated Kinase (ERK) Signaling Network

(2010) Murat Cirit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological levels of TNF  stimulation induce stochastic dynamics of NF- B responses in single living cells

(2010) D. A. Turner et al.   JOURNAL OF CELL SCIENCE

Transcriptional feedbacks in mammalian signal transduction pathways facilitate rapid and reliable protein induction

(2010) Nils Blüthgen   Molecular BioSystems

Short-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression

(2010) Luca Mariani et al.   Molecular Systems Biology

Cis-interactions between Notch and Delta generate mutually exclusive signalling states

(2010) David Sprinzak et al.   NATURE

Population robustness arising from cellular heterogeneity

(2010) P. Paszek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Sources of Robustness in Biochemical Reaction Networks

(2010) G. Shinar et al.   SCIENCE

The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier

(2010) O. E. Sturm et al.   Science Signaling

Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood

(2009) A. Raue et al.   BIOINFORMATICS

A Systems-Level Analysis of Perfect Adaptation in Yeast Osmoregulation

(2009) Dale Muzzey et al.   CELL

A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts

(2009) Nils Blüthgen et al.   FEBS Journal

Dynamics and Variability of ERK2 Response to EGF in Individual Living Cells

(2009) Cellina Cohen-Saidon et al.   MOLECULAR CELL

Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling

(2009) Lea Goentoro et al.   MOLECULAR CELL

Population context determines cell-to-cell variability in endocytosis and virus infection

(2009) Berend Snijder et al.   NATURE

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression

(2009) D. Nevozhay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Getting the Measure of Positional Information

(2009) Johannes Jaeger et al.   PLOS BIOLOGY

Role of Translational Coupling in Robustness of Bacterial Chemotaxis Pathway

(2009) Linda Løvdok et al.   PLOS BIOLOGY

Noise Management by Molecular Networks

(2009) Frank J. Bruggeman et al.   PLoS Computational Biology

BRAF V600E Disrupts AZD6244-Induced Abrogation of Negative Feedback Pathways between Extracellular Signal-Regulated Kinase and Raf Proteins

(2008) B. B. Friday et al.   CANCER RESEARCH

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

Systems analysis of MAPK signal transduction

(2008) Nils Blüthgen et al.   Essays in Biochemistry

Kinetic mechanisms for overexpression insensitivity and oncogene cooperation

(2008) Stefan Legewie et al.   FEBS LETTERS

Recurrent design patterns in the feedback regulation of the mammalian signalling network

(2008) Stefan Legewie et al.   Molecular Systems Biology

Scaling of the BMP activation gradient in Xenopus embryos

(2008) Danny Ben-Zvi et al.   NATURE

Transcriptional Autoregulatory Loops Are Highly Conserved in Vertebrate Evolution

(2008) Szymon M. Kiełbasa et al.   PLoS One

Variability and Robustness in T Cell Activation from Regulated Heterogeneity in Protein Levels

(2008) O. Feinerman et al.   SCIENCE

Signalling control strength

(2007) Hans V. Westerhoff   JOURNAL OF THEORETICAL BIOLOGY