Article
Immunology
Elizabeth Robins, Ming Zheng, Qingshan Ni, Siqi Liu, Chen Liang, Baojun Zhang, Jian Guo, Yuan Zhuang, You-Wen He, Ping Zhu, Ying Wan, Qi-Jing Li
Summary: Recent research has revealed that CD4(+) and CD8(+) T cells in adaptive immunity can exhibit significant lineage plasticity, even undergoing fundamental lineage reprogramming. This shift in functional potential may suggest a new direction for HIV vaccine design.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Hengcheng Zhang, Cecilia B. Cavazzoni, Manuel A. Podesta, Elsa D. Bechu, Garyfallia Ralli, Pragya Chandrakar, Jeong-Mi Lee, Ismail Sayin, Stefan G. Tullius, Reza Abdi, Anita S. Chong, Bruce R. Blazar, Peter T. Sage
Summary: This study found that a specific subset of effector Tfh cells was activated during allogeneic kidney transplantation, and these cells played a crucial role in transplant rejection by regulating the clonal dynamics of donor-specific germinal center B cells.
Article
Multidisciplinary Sciences
Andrew Baessler, Bryce Fuchs, Bryant Perkins, Andrew W. Richens, Camille L. Novis, Malia Harrison-Chau, Linda M. Sircy, Kendall A. Thiede, J. Scott Hale
Summary: This study reveals the important role of Tet2 in CD4+ T cell differentiation and memory formation, which in turn affects the enhancement of immune response. The absence of Tet2 leads to preferential recall of Tfh phenotype in memory cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Immunology
Daniel DiToro, Rajatava Basu
Summary: The intestinal immune system plays a crucial role in protecting the epithelial layer from pathogens and inflammation, which could lead to diseases such as colorectal cancer. CD4(+)T cells have a diverse range of functions in regulating intestinal inflammation, including both suppression and promotion. The heterogeneity of CD4(+)T cells in colorectal cancer and their dynamic responses offer potential opportunities for targeted intervention strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Enrique Huanosta-Murillo, Marcela Alcantara-Hernandez, Brenda Hernandez-Rico, Georgina Victoria-Acosta, Patricia Miranda-Cruz, Maria Antonieta Dominguez-Gomez, Fermin Jurado-Santacruz, Genaro Patino-Lopez, Vadim Perez-Koldenkova, Alam Palma-Guzman, Paula Licona-Limon, Ezequiel M. Fuentes-Panana, Alicia Lemini-Lopez, Laura C. Bonifaz
Summary: In cutaneous T cell lymphoma (CTCL), a dominant Th2 profile associated with disease progression has been proposed, with TOX+ CD4(+) T cells producing IL-4(+) in early-stage skin lesions. The NLRP3 receptor plays a role in promoting a Th2 response by controlling IL-4 production, which may have significant implications in disease progression. This mechanism of IL-4 regulation mediated by NLRP3 is amplified in late-stage CTCL, indicating its importance in disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Elodie Renaude, Marie Kroemer, Christophe Borg, Paul Peixoto, Eric Hervouet, Romain Loyon, Olivier Adotevi
Summary: The review discusses the role of CD4(+) Th cells in anticancer immunity and emphasizes the importance of epigenetics. Research describes how epigenetic factors regulate the differentiation and recruitment of CD4(+) T cells. Furthermore, the potential of using epigenetic drugs to enhance anticancer immunotherapy is explored.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Allergy
Duncan M. Morgan, Wayne G. Shreffler, J. Christopher Love
Summary: Single-cell RNA sequencing is a powerful tool for studying gene expression and has been widely applied to profile the phenotypes and clonotypes of CD4+ T cells. It allows for the investigation of cellular heterogeneity and interactions between CD4+ T cells and other cells. The technology has great potential to advance our understanding of the roles of CD4+ T cells in health and disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Michael L. Dixon, Jonathan D. Leavenworth, Jianmei W. Leavenworth
Summary: Regulatory T-cells, particularly effector Tregs (eTregs), play a crucial role in maintaining self-tolerance and tissue homeostasis, with potential implications in tumor development. Understanding the mechanisms that modulate the stability and suppressive function of tumoral Tregs, such as eTregs and T-FR cells, can lead to the development of more effective cancer immunotherapies that target the tumor microenvironment while minimizing systemic side effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Oscar J. Cordero, Carlos Rafael-Vidal, Ruben Varela-Calvino, Cristina Calvino-Sampedro, Beatriz Malvar-Fernandez, Samuel Garcia, Juan E. Vinuela, Jose M. Pego-Reigosa
Summary: Immune system CD4 T-cells with high cell-surface CD26 expression demonstrate anti-tumoral properties, especially when engineered with a chimeric antigen receptor. Different T helper cell subsets show variations in CD26 expression levels, which could impact research on CAR-T cells. The relationship between glycoprotein sCD26 and its enzymatic activity, as well as its correlation with specific T cell subsets, still requires further understanding.
Review
Immunology
Marco Kunzli, David Masopust
Summary: This review provides updates on our understanding of the biology of memory CD4(+) T cells as well as key technological advances that facilitate their characterization.
Article
Immunology
Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L. Namminga, Katherine E. Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M. Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D. Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y. Poluektova, Channabasavaiah B. Gurumurthy, R. Lee Mosley, Howard E. Gendelman
Summary: Alzheimer's disease is characterized by pathological deposition of misfolded self-protein amyloid beta, leading to neuroinflammation. Effector T cells induced by self-antigens accelerate disease progression, suggesting a potential therapeutic target in controlling AD pathology.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Kaitlin A. Read, Devin M. Jones, Srijana Pokhrel, Emily D. S. Hales, Aditi Varkey, Jasmine A. Tuazon, Caprice D. Eisele, Omar Abdouni, Abbey Saadey, Melissa R. Leonard, Robert T. Warren, Michael D. Powell, Jeremy M. Boss, Emily A. Hemann, Jacob S. Yount, Gang Xin, Hazem E. Ghoneim, Chan-Wang J. Lio, Aharon G. Freud, Patrick L. Collins, Kenneth J. Oestreich
Summary: During intracellular infection, T follicular helper (T-FH) and T helper 1 (T(H)1) cells have different roles in promoting immune responses. This study identifies Aiolos as a crucial regulator of T-FH and CD4-CTL programming. Aiolos deficiency leads to reduced T-FH differentiation and antibody production, while increasing CD4-CTL programming and cytolytic molecule expression.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Amania A. Sheikh, Joanna R. Groom
Summary: During viral infection, CD4(+) T cells differentiate into Th1 cells for inflammation and pathogen clearance, or Tfh cells for enhancing germinal center reactions. The lineage-defining transcription factors T-bet and Bcl6 play key roles in determining the fate of CD4(+) T cells toward Th1 or Tfh. Transcriptional networks guided by cytokine cues dynamically shape the fate and function of these cells during infection.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Lawrence P. Andrews, Kate M. Vignali, Andrea L. Szymczak-Workman, Amanda R. Burton, Erin A. Brunazzi, Shin Foong Ngiow, Akihito Harusato, Arlene H. Sharpe, E. John Wherry, Ichiro Taniuchi, Creg J. Workman, Dario A. A. Vignali
Summary: This study developed a new mouse line for precise gene manipulation in CD4(+) T cells and CD4(+) Tconv cells, which was validated through comparisons with existing mouse lines targeting CD8(+) T cells. These engineered mouse strains provide a valuable resource for temporal control of gene expression in specific T cell populations.
Article
Rheumatology
Lucas L. Lintermans, Coen A. Stegeman, Ernesto J. Munoz-Elias, Eric J. Tarcha, Shawn P. Iadonato, Abraham Rutgers, Peter Heeringa, Wayel H. Abdulahad
Summary: This study aimed to provide a new treatment strategy for GPA by modulating the activity of CD4(+)T(EM) cells using the specific peptide inhibitor, ShK-186. The results showed that ShK-186 reduced the expression levels of IFN gamma, TNF alpha, IL-4, IL-17, and IL-21 in CD4(+)T(H) cells from patients with GPA.