Article
Multidisciplinary Sciences
Anja Holm, Marie-Laure Possovre, Mojtaba Bandarabadi, Kristine F. Moseholm, Jessica L. Justinussen, Ivan Bozic, Rene Lemcke, Yoan Arribat, Francesca Amati, Asli Silahtaroglu, Maxime Juventin, Antoine Adamantidis, Mehdi Tafti, Birgitte R. Kornum
Summary: This study found that miR-137 regulates sleep-wake states by targeting the Hcrt gene. Inhibition of miR-137 increases Hcrt expression and prolongs wakefulness, and this interaction is evolutionarily conserved in different species. Additionally, the study showed that miR-137 expression is regulated by IL-13, and Hcrt gene expression is regulated by miR-137.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
William T. Schneider, Szilvia Vas, Alister U. Nicol, A. Jennifer Morton
Summary: Research showed that in sheep with HD, transitions into wake were more sudden and accompanied by less reduction in slow wave power compared to normal sheep, indicating impaired readiness for waking. These abnormal dynamics of sleep transitions may potentially serve as an early biomarker for HD and could be applied to studying transition dynamics in other sleep disorders as well.
Article
Neurosciences
Gary B. Kaplan, Gabrielle A. Lakis, Hryhoriy Zhoba
Summary: This review emphasizes the significance of the orexin neural system in the pathophysiology of PTSD. Orexinergic neurons play a crucial role in fear behaviors, sleep disturbances, and stress responses. Activation of the orexin system is associated with increased fear expression, impaired sleep, and heightened stress.
BRAIN RESEARCH BULLETIN
(2022)
Article
Psychiatry
Christopher W. Thomas, Cristina Blanco-Duque, Benjamin J. Breant, Guy M. Goodwin, Trevor Sharp, David M. Bannerman, Vladyslav V. Vyazovskiy
Summary: Serotonergic psychedelic drugs, such as psilocin, affect sleep and vigilance state by delaying REM sleep onset, reducing NREM sleep maintenance, and enhancing 4 Hz cortical oscillation. However, these drugs do not significantly affect sleep-wake quantity and sleep recovery following sleep deprivation. Nevertheless, psilocin inhibits the recovery rate of sleep slow-wave activity in specific areas.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Jessica L. Justinussen, Christine Egebjerg, Birgitte R. Kornum
Summary: Excessive daytime sleepiness is a complex symptom characterized by strong urge to sleep during daytime and accompanied by attention deficits, anxiety, and lower cognitive performance. Treatment strategies for EDS have focused on decreasing sleepiness, but less attention has been given to the quality of wakefulness. This review discusses the potential effects of HCRTR2 agonists on attention and anxiety in treating EDS, suggesting that these compounds may improve both the quantity and quality of wakefulness in narcolepsy.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Ryan J. Keenan, Heather Daykin, Jiahui Chu, Linda Cornthwaite-Duncan, Giancarlo Allocca, Daniel Hoyer, Laura H. Jacobson
Summary: This study investigates the effects of sleep-promoting compounds in transgenic mouse models of tauopathy and finds that these compounds can effectively improve sleep disturbances. The results also suggest that there may be gender differences in the response to hypnotics, which could have implications for the treatment of neurodegenerative disorders in humans.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Neurosciences
Fan Gao, Tao Liu, Miao Tuo, Song Chi
Summary: Accumulating evidence suggests that sleep disturbance is a common symptom in Alzheimer's disease (AD) and orexin system dysregulation is associated with cognitive impairment in AD patients. Orexin receptor antagonists may be a promising target for the prevention or treatment of AD.
NEUROSCIENCE LETTERS
(2021)
Article
Multidisciplinary Sciences
Aurelie Davin, Stephan Chabardes, Hayat Belaid, Daniel Fagret, Loic Djaileb, Yves Dauvilliers, Olivier David, Napoleon Torres-Martinez, Brigitte Piallat
Summary: Parkinsonian patients often experience early sleep/wake disturbances, characterized by disorganized nighttime sleep and excessive daytime sleepiness.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Jamie M. Zeitzer
Summary: The circadian wake drive represents the increased propensity to stay awake late in the day, peaking just before anticipated bed time. Referred to as the "forbidden zone," it causes difficulties in initiating sleep during this time, leading to various sleep issues.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Neurosciences
I. P. Alonso, J. A. Pino, S. Kortagere, G. E. Torres, R. A. Espana
Summary: The study found that sleep/wake states have an impact on DA terminal neurotransmission, with higher DA uptake rate, increased phosphorylation of DAT, and enhanced cocaine potency observed after periods of sleep.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Aurelie Brecier, Melodie Borel, Nadia Urbain, Luc J. Gentet
Summary: GABAergic inhibitory neurons play a crucial role in regulating cortical circuit activity during the sleep/wake cycle. This study investigated the activity dynamics of PV, VIP, and SST neurons in the somatosensory cortex of sleeping mice. The findings revealed that PV neurons were most active during both REM and NREM sleep, VIP neurons were most active during REM sleep, and the overall activity of SST neurons remained stable throughout the sleep/wake cycle. Furthermore, the study found that ongoing delta and theta oscillations influenced the activity of most neurons, except for SST neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Mattia Aime, Niccolo Calcini, Micaela Borsa, Tiago Campelo, Thomas Rusterholz, Andrea Sattin, Tommaso Fellin, Antoine Adamantidis
Summary: During REM sleep, somatodendritic decoupling in pyramidal neurons of the prefrontal cortex occurs, mainly driven by neurons from the central medial thalamus. This decoupling promotes opposite synaptic plasticity mechanisms that optimize emotional responses to future behavioral stressors.
Article
Computer Science, Artificial Intelligence
Csongor Varady, Riccardo Volpi, Luigi Malago, Nihat Ay
Summary: This paper introduces the algorithms NRWS and NBiHM, based on natural gradient, for efficient training of generative models HMs. The experimental results show significant improvements in terms of convergence speed and log-likelihood compared to non-geometric baselines and state-of-the-art training algorithms for HMs.
Article
Clinical Neurology
Louise Piilgaard, Laura Rose, Camille Gylling Hviid, Kristi A. Kohlmeier, Birgitte Rahbek Kornum
Summary: This study investigated the effect of sex on NT1 symptoms and sleep-wake characteristics using NT1 mice. The findings showed that females exhibited higher behavioral state instability, more wakefulness and less sleep during the dark phase, and decreased REM sleep compared to males. The study also identified a new type of behavioral arrest called delta attacks.
Article
Clinical Neurology
Dmitri Yousef Yengej, Sinifunanya E. Nwaobi, Isabella Ferando, Gayane Kechechyan, Andrew Charles, Guido C. Faas
Summary: The study aims to characterize the effects of the sleep-wake cycle on cortical spreading depression (CSD) and found that the sleep-wake cycle has significant effects on the threshold, duration, and neurovascular and behavioral responses of CSD.
Article
Neurosciences
Zhi Wang, Shu-Na Wang, Tian-Ying Xu, Chen Hong, Ming-He Cheng, Peng-Xi Zhu, Jian-Sheng Lin, Ding-Feng Su, Chao-Yu Miao
CNS NEUROSCIENCE & THERAPEUTICS
(2020)
Editorial Material
Neurosciences
Cesario Borlongan, Frederic Dorandeu, Giuseppe Di Giovanni, Jian-Sheng Lin, Gang Hu, Johannes Boltze, Jie Wu, Xiaoming Hu, Yumin Luo
CNS NEUROSCIENCE & THERAPEUTICS
(2020)
Article
Mathematical & Computational Biology
Michael C. Chen, Siamak K. Sorooshyari, Jian-Sheng Lin, Jun Lu
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2020)
Article
Neurosciences
Min Zhang, Clara Odilia Inocente, Carine Villanueva, Michel Lecendreux, Yves Dauvilliers, Jian-Sheng Lin, Isabelle Arnulf, Marie-Paule Gustin, Marine Thieux, Patricia Franco
CNS NEUROSCIENCE & THERAPEUTICS
(2020)
Review
Neurosciences
Xinyan Zhang, Jian-Sheng Lin, Karen Spruyt
Summary: The research reviewed the sleep studies of animal models of RTT and found disruptions in sleep patterns across genetically mutated models, similar to sleep complaints reported in individuals with RTT. Further studies are needed to explore EEG alterations and sleep apnea mechanisms in different sleep stages.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Clinical Neurology
Chiara Berteotti, Viviana Lo Martire, Sara Alvente, Stefano Bastianini, Gabriele Matteoli, Hiroshi Ohtsu, Jian-Sheng Lin, Alessandro Silvani, Giovanna Zoccoli
Summary: This study found that the occurrence rate of tibialis anterior electromyogram bursts during sleep was significantly lower in mice with histamine deficiency compared to wild-type mice. The data suggest that limb movements during sleep may depend on the integrity of brain histamine signaling.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Medicine, General & Internal
Marine Thieux, Min Zhang, Agathe Marcastel, Vania Herbillon, Anne Guignard-Perret, Laurent Seugnet, Jian-Sheng Lin, Aurore Guyon, Sabine Plancoulaine, Patricia Franco
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Neurosciences
Chiara Berteotti, Viviana Lo Martire, Sara Alvente, Stefano Bastianini, Cristiano Bombardi, Gabriele Matteoli, Hiroshi Ohtsu, Jian-Sheng Lin, Alessandro Silvani, Giovanna Zoccoli
Summary: The loss of hypothalamic neurons producing wake-promoting orexin is responsible for narcolepsy type 1. While histamine neurons are increased in NT1 patients, orexin-deficient mice show inconsistent results. However, histamine deficiency does not significantly affect orexin neuron development in mammals.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Damien Dupont, Jian-Sheng Lin, Francois Peyron, Hideo Akaoka, Martine Wallon
Summary: The study demonstrated that Toxoplasma gondii infection can lead to chronic alterations in sleep-wake states in mice, characterized by increased time spent awake, increased cortical EEG theta power density, and decreased slow-wave sleep. These effects can be alleviated by anti-inflammatory treatment with corticosteroid dexamethasone, shedding light on the neurodegenerative and neuropsychiatric disorders reported in infected patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Chemistry, Medicinal
Stefanie Hagenow, Anna Affini, Elsa Y. Pioli, Sonja Hinz, Yan Zhao, Gregory Porras, Vigneshwaran Namasivayam, Christa E. Mueller, Jian-Sheng Lin, Erwan Bezard, Holger Stark
Summary: This study developed multitargeting ligands for Parkinson's disease, combining receptor antagonists to improve symptoms.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Neurosciences
Min Zhang, Marine Thieux, Clara Odilia Inocente, Noemie Vieux, Laura Arvis, Carine Villanueva, Jian-Sheng Lin, Sabine Plancoulaine, Aurore Guyon, Patricia Franco
Summary: This study characterizes the rapid weight gain (RWG) phenotype associated with childhood narcolepsy and suggests that RWG could be a marker of disease severity. Patients with RWG had a younger age at diagnosis, higher sleepiness levels, and a higher prevalence of obesity compared to non-RWG patients. Furthermore, RWG patients had a higher risk of long-term obesity despite improvement in narcoleptic symptoms.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Pediatrics
Sabine Plancoulaine, Aurore Guyon, Clara-Odilia Inocente, Philippine Germe, Min Zhang, Philippe Robert, Jian-Sheng Lin, Patricia Franco
Summary: This study aims to investigate the maturation of the histamine system and its involvement in SIDS in healthy children. The results show that the levels of cerebrospinal fluid histamine decrease with age in boys, and overall levels are lower in boys than in girls.
FRONTIERS IN PEDIATRICS
(2022)
Letter
Neurosciences
Laurent Seugnet, Christelle Anaclet, Magali Perier, Jean-Francois Ghersi-Egea, Jian-Sheng Lin
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Environmental Sciences
Hai-Lin Chen, Jin-Xian Gao, Yu-Nong Chen, Jun-Fan Xie, Yu-Ping Xie, Karen Spruyt, Jian-Sheng Lin, Yu-Feng Shao, Yi-Ping Hou
Summary: The study explores the significance of REM sleep in the maturation of the central nervous system, finding that a large amount of REM sleep in early life helps with brain development. It also investigates REM sleep disturbances associated with certain disorders.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Min Zhang, Marine Thieux, Laura Arvis, Jian-Sheng Lin, Aurore Guyon, Sabine Plancoulaine, Carine Villanueva, Patricia Franco
Summary: The prevalence of metabolic syndrome (MS) in children with narcolepsy was investigated, and their clinical and sleep characteristics were evaluated according to different components of MS. It was found that 17.2% of children with narcolepsy had MS, with insulin resistance being the core metabolic disturbance. Children with at least two components of MS had more severe daytime sleepiness and a higher prevalence of night-eating behaviors. Early evaluation and management may be beneficial for these children to prevent future complications.
