期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 68, 期 15, 页码 2499-2512出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0631-8
关键词
Wake; Sleep; Cortical activation; Histamine; Orexin
Wakefulness and consciousness depend on perturbation of the cortical soliloquy. Ascending activation of the cerebral cortex is characteristic for both waking and paradoxical (REM) sleep. These evolutionary conserved activating systems build a network in the brainstem, midbrain, and diencephalon that contains the neurotransmitters and neuromodulators glutamate, histamine, acetylcholine, the catecholamines, serotonin, and some neuropeptides orchestrating the different behavioral states. Inhibition of these waking systems by GABAergic neurons allows sleep. Over the past decades, a prominent role became evident for the histaminergic and the orexinergic neurons as a hypothalamic waking center.
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