Article
Medicine, Research & Experimental
Jian Zhang, Hongyan Zhang, Xiuli Ding, Jia Hu, Yongkui Li, Jinxiang Zhang, Hui Wang, Shanshan Qi, Aqing Xie, Jie Shi, Mengxi Xiang, Yawen Bin, Guobin Wang, Lin Wang, Zheng Wang
Summary: This study reveals a previously unappreciated TAM-mediated oncogenic network in hepatocellular carcinoma (HCC), where TAMs induce and maintain high levels of HCC UHRF1 expression, leading to the dysregulation of tumor inhibitory factors KLF6 and miR-520d. Targeting this network may provide a new approach for the treatment of HCC patients.
Review
Immunology
Silvia Gaggero, Kristina Witt, Mattias Carlsten, Suman Mitra
Summary: NK cells play a crucial role in tumor immune surveillance but can be rendered ineffective within the tumor microenvironment due to suppressive factors, primarily influenced by myeloid cells. While NK-myeloid cell crosstalk can promote anti-tumor responses, it can also lead to dysregulation of NK cells, affecting their function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Constance Baer, Shunsuke Kimura, Mitra S. Rana, Andrew B. Kleist, Tim Flerlage, David J. Feith, Peter Chockley, Wencke Walter, Manja Meggendorfer, Thomas L. Olson, HeeJin Cheon, Kristine C. Olson, Aakrosh Ratan, Martha-Lena Mueller, James M. Foran, Laura J. Janke, Chunxu Qu, Shaina N. Porter, Shondra M. Pruett-Miller, Ravi C. Kalathur, Claudia Haferlach, Wolfgang Kern, Elisabeth Paietta, Paul G. Thomas, M. Madan Babu, Thomas P. Loughran, Ilaria Iacobucci, Torsten Haferlach, Charles G. Mullighan
Summary: This study reveals the hallmark of a distinct subset of chronic lymphoproliferative disorder of natural killer cells (CLPD-NK) through somatic mutations in the chemokine gene CCL22. These mutations result in biased signaling downstream of the chemokine receptor, leading to increased cell chemotaxis and NK cell proliferation through interactions with the hematopoietic microenvironment.
Review
Biochemistry & Molecular Biology
Yongqiang Zhou, Lu Cheng, Lu Liu, Xun Li
Summary: Immune escape is a characteristic of cancer, and the tumor microenvironment plays a role in inhibiting the effectiveness of natural killer cell-based immunotherapy. Understanding the interaction between natural killer cells and the tumor microenvironment can help improve immunotherapy strategies.
Review
Immunology
Benedikt Jacobs, Veronika Gebel, Lukas Heger, Victoria Greze, Hansjorg Schild, Diana Dudziak, Evelyn Ullrich
Summary: Cellular therapy, including CAR T cell and DCs vaccines, has become a part of daily clinical practice. To ensure sustained therapeutic success, challenges such as strategies to combat tumor escape mechanisms and establish an immunosuppressive tumor microenvironment need to be addressed. The interaction of DCs and NK cells within the TME is crucial for understanding and potentially improving cancer treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Azadeh Rahimi, Zahra Malakoutikhah, Ilnaz Rahimmanesh, Gordon A. Ferns, Reza Nedaeinia, Sayed Mohammad Matin Ishaghi, Nasim Dana, Shaghayegh Haghjooy Javanmard
Summary: This translation describes the importance of melanoma cell metastasis in patients and the role of NK cells in the immune system in combating melanoma and inhibiting metastasis. It also emphasizes the complex relationship between the melanoma tumor microenvironment and NK cells.
CANCER CELL INTERNATIONAL
(2023)
Article
Immunology
Jingping Zhou, Shaolong Zhang, Changying Guo
Summary: The tumor microenvironment is shaped by various cell types that interact with tumor cells to influence tumor development. Macrophages and NK cells play a crucial role in regulating the immune response within the TME through cytokine signaling and cell-to-cell interactions, affecting the efficacy of immune responses against cancer cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Cell Biology
Milad Moloudizargari, Ali Govahi, Marjan Fallah, Mohammad A. Rezvanfar, Mohammad H. Asghari, Mohammad Abdollahi
Summary: Understanding the interaction between MSCs and NK cells is crucial for developing therapeutic approaches, though the current knowledge in this area is still in its early stages and further well-defined studies are warranted.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Yan-Hui Li, Dong Zhu, Tianye Yang, Long Cheng, Jian Sun, Lei Tan
Summary: The study found that LMHFV can stimulate OB differentiation by activating the COX2-PGE2-EP pathway dependent on primary cilia and that the PGE2 pathway also affects primary cilia. LMHFV can reduce the length and abundance of primary cilia, but cells can self-repair them. EP4 antagonist significantly blocked the LMHFV-induced increase in IFT88 expression and the recovery of primary cilia length.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Xiangyu Hu, Xiaoqin Jia, Cong Xu, Yingying Wei, Zhengbing Wang, George Liu, Qiang You, Guotao Lu, Weijuan Gong
Summary: NK cell impairment in Apoc3-induced hyperlipidemia is associated with increased fatty acid oxidation and reduced glycolysis. Moreover, DCs in Apoc3(TG) mice may exert bystander suppression on NK cell activities through increased lipid content.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Immunology
Mohd Israr, Fung Lam, James DeVoti, Emily M. Mace, Christopher Papayannakos, Allan Abramson, Bettie M. Steinberg, Vincent R. Bonagura
Summary: Recurrent respiratory papillomatosis (RRP) is a rare chronic disease caused primarily by human papillomavirus types 6 and 11, characterized by repeated growth of premalignant papillomas in the airway. In this study, we identified and characterized a mechanism that blocks NK cell targeting of papilloma cells. The secreted PGE(2) by papilloma cells directly inhibits NK cells activation/degranulation mainly through the PGE(2) receptor EP2, and to a lesser extent through EP4 signaling. These findings suggest that papilloma cells have a potent mechanism to block NK cell function and support papilloma cell growth.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eva Persyn, Sigrid Wahlen, Laura Kiekens, Sylvie Taveirne, Wouter Van Loocke, Els Van Ammel, Filip Van Nieuwerburgh, Tom Taghon, Bart Vandekerckhove, Pieter Van Vlierberghe, Georges Leclercq
Summary: This study investigated the role of TXNIP in human NK cell differentiation and found that TXNIP promotes human NK cell differentiation by affecting protein synthesis and proliferation of early NK cell differentiation stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Oncology
Shoubao Ma, Michael A. Caligiuri, Jianhua Yu
Summary: This study identifies a four-stage developmental model for mouse NK cell development and defines two distinct populations of immature NK cells.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jose Lourenco Reis, Natacha Nurdine Rosa, Miguel Angelo-Dias, Catarina Martins, Luis Miguel Borrego, Jorge Lima
Summary: Endometriosis is a chronic inflammatory disorder characterized by the presence of endometrial cells outside the uterus. Studies indicate a correlation between the immune system, particularly NK receptors (NKR), and endometriosis, suggesting their essential role in the disease's pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Kevin J. J. Lopez, Arthur A. A. Cross-Najafi, Kristine Farag, Benjamin Obando, Deepthi Thadasina, Abdulkadir Isidan, Yujin Park, Wenjun Zhang, Burcin Ekser, Ping Li
Summary: Eliminating major xenoantigens has reduced hyperacute xenograft rejection, but acute rejection remains a challenge in xenotransplantation. NK cells play a role in both cytotoxicity against xenogeneic cells and affecting other immune cells through cytokine secretion. The regulation of NK cell activating and inhibitory receptors is crucial in determining the NK cell response. Inhibition of NK cell activity can protect xenografts. Recent advancements in genetic modifications of porcine xenografts have shown promise in reducing NK cell-mediated rejection. Future research on NK cell tolerance in pregnancy and NK cell evasion in viral infection can further promote xenograft acceptance.
FRONTIERS IN IMMUNOLOGY
(2022)