HIV-1 immunopathogenesis in humanized mouse models

Cutting Edge: Experimentally Induced Immune Activation in Natural Hosts of Simian Immunodeficiency Virus Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion

(2014) I. Pandrea et al.   JOURNAL OF IMMUNOLOGY

Alpha Interferon and HIV Infection Cause Activation of Human T Cells in NSG-BLT Mice

(2012) B. R. Long et al.   JOURNAL OF VIROLOGY

Microbial translocation predicts disease progression of HIV-infected antiretroviral-naive patients with high CD4+ cell count

(2011) Giulia Marchetti et al.   AIDS

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

(2011) C. Rathinam et al.   BLOOD

Efficient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2-/-  C-/- mice in vivo

(2011) L. Zhang et al.   BLOOD

Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders

(2011) S. Piconi et al.   BLOOD

Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R null humanized mice

(2011) E. Billerbeck et al.   BLOOD

Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rγnull H2-Ab1 tm1Gru Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease

(2011) L. Covassin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

HLA-A2-Matched Peripheral Blood Mononuclear Cells From Type 1 Diabetic Patients, but Not Nondiabetic Donors, Transfer Insulitis to NOD-scid/ cnull/HLA-A2 Transgenic Mice Concurrent With the Expansion of Islet-Specific CD8+ T cells

(2011) F. Whitfield-Larry et al.   DIABETES

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

(2011) Lee Adam Wheeler et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque

(2011) Margalida Rotger et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Natural Regulatory T Cell Development, Suppressive Function, and Postthymic Maturation in a Humanized Mouse Model

(2011) T. Onoe et al.   JOURNAL OF IMMUNOLOGY

Loss of Neuronal Integrity during Progressive HIV-1 Infection of Humanized Mice

(2011) P. K. Dash et al.   JOURNAL OF NEUROSCIENCE

Dynamics of Simian Immunodeficiency Virus SIVmac239 Infection in Pigtail Macaques

(2011) N. R. Klatt et al.   JOURNAL OF VIROLOGY

Immunovirological Analyses of Chronically Simian Immunodeficiency Virus SIVmnd-1- and SIVmnd-2-Infected Mandrills (Mandrillus sphinx)

(2011) C. Apetrei et al.   JOURNAL OF VIROLOGY

HIV Latency in the Humanized BLT Mouse

(2011) M. D. Marsden et al.   JOURNAL OF VIROLOGY

Increased Frequency of Regulatory T Cells Accompanies Increased Immune Activation in Rectal Mucosae of HIV-Positive Noncontrollers

(2011) J. M. Shaw et al.   JOURNAL OF VIROLOGY

Latent HIV-1 Infection of Resting CD4+ T Cells in the Humanized Rag2-/-  c-/- Mouse

(2011) S. K. Choudhary et al.   JOURNAL OF VIROLOGY

One Percent Tenofovir Applied Topically to Humanized BLT Mice and Used According to the CAPRISA 004 Experimental Design Demonstrates Partial Protection from Vaginal HIV Infection, Validating the BLT Model for Evaluation of New Microbicide Candidates

(2011) P. W. Denton et al.   JOURNAL OF VIROLOGY

Generation of HIV Latency in Humanized BLT Mice

(2011) P. W. Denton et al.   JOURNAL OF VIROLOGY

Systemic Administration of Combinatorial dsiRNAs via Nanoparticles Efficiently Suppresses HIV-1 Infection in Humanized Mice

(2011) Jiehua Zhou et al.   MOLECULAR THERAPY

Humanized Rag1−/−γc−/− Mice Support Multilineage Hematopoiesis and Are Susceptible to HIV-1 Infection via Systemic and Vaginal Routes

(2011) Ramesh Akkina et al.   PLoS One

Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells

(2011) Rebecca Danner et al.   PLoS One

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

(2011) A. Rongvaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

(2011) T. Willinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional CD47/signal regulatory protein alpha (SIRPα) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo

(2011) Nicolas Legrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/−mice improves engraftment of human hematopoietic cells in humanized mice

(2011) Till Strowig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice

(2011) C. P. Neff et al.   Science Translational Medicine

Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement

(2011) Tim Willinger et al.   TRENDS IN IMMUNOLOGY

Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2Rγ−/− (NSG) BLT mice

(2011) Cheryl A. Stoddart et al.   VIROLOGY

Highly Active Antiretroviral Therapy Potently Suppresses HIV Infection in Humanized Rag2-/-γc-/- Mice

(2010) Kaori Sango et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Links between Progressive HIV-1 Infection of Humanized Mice and Viral Neuropathogenesis

(2010) Santhi Gorantla et al.   AMERICAN JOURNAL OF PATHOLOGY

Engraftment of human hematopoietic stem cells is more efficient in female NOD/SCID/IL-2Rgc-null recipients

(2010) F. Notta et al.   BLOOD

B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy

(2010) S. Moir et al.   BLOOD

Comparison of human cord blood engraftment between immunocompromised mouse strains

(2010) S. P. McDermott et al.   BLOOD

Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation

(2010) Michael A. Brehm et al.   CLINICAL IMMUNOLOGY

CD8+ Cell Depletion Accelerates HIV-1 Immunopathology in Humanized Mice

(2010) S. Gorantla et al.   JOURNAL OF IMMUNOLOGY

Long-Term Human CD34+ Stem Cell-Engrafted Nonobese Diabetic/SCID/IL-2R null Mice Show Impaired CD8+ T Cell Maintenance and a Functional Arrest of Immature NK Cells

(2010) M. C. Andre et al.   JOURNAL OF IMMUNOLOGY

Plasmacytoid dendritic cells in HIV infection: striking a delicate balance

(2010) Patricia Fitzgerald-Bocarsly et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Brain ingress of regulatory T cells in a murine model of HIV-1 encephalitis☆

(2010) Nan Gong et al.   JOURNAL OF NEUROIMMUNOLOGY

Reduction of Immune Activation with Chloroquine Therapy during Chronic HIV Infection

(2010) S. M. Murray et al.   JOURNAL OF VIROLOGY

Remarkable Lethal G-to-A Mutations in vif-Proficient HIV-1 Provirus by Individual APOBEC3 Proteins in Humanized Mice

(2010) K. Sato et al.   JOURNAL OF VIROLOGY

Inhibition of In Vivo HIV Infection in Humanized Mice by Gene Therapy of Human Hematopoietic Stem Cells with a Lentiviral Vector Encoding a Broadly Neutralizing Anti-HIV Antibody

(2010) A. Joseph et al.   JOURNAL OF VIROLOGY

Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

(2010) L. D. Harris et al.   JOURNAL OF VIROLOGY

Systemic Administration of Antiretrovirals Prior to Exposure Prevents Rectal and Intravenous HIV-1 Transmission in Humanized BLT Mice

(2010) Paul W. Denton et al.   PLoS One

Oral Pre-Exposure Prophylaxis by Anti-Retrovirals Raltegravir and Maraviroc Protects against HIV-1 Vaginal Transmission in a Humanized Mouse Model

(2010) C. Preston Neff et al.   PLoS One

Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r null humanized mice

(2010) L. D. Shultz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First Report on a Series of HIV Patients Undergoing Rapamycin Monotherapy After Liver Transplantation

(2010) Fabrizio Di Benedetto et al.   TRANSPLANTATION

Dynamics of memory and naïve CD8+ T lymphocytes in humanized NOD/SCID/IL-2Rγnull mice infected with CCR5-tropic HIV-1

(2010) Kei Sato et al.   VACCINE

Inadequate Clearance of Translocated Bacterial Products in HIV-Infected Humanized Mice

(2010) Ursula Hofer et al.   PLoS Pathogens

Safe use of raltegravir and sirolimus in an HIV-infected patient with renal impairment after orthotopic liver transplantation

(2009) Ana Moreno et al.   AIDS

Regulatory T cells in HIV infection: pathogenic or protective participants in the immune response?

(2009) Barbara Fazekas de St Groth et al.   AIDS

Immune activation and AIDS pathogenesis

(2009) Donald L Sodora et al.   AIDS

Plasmacytoid dendritic cells accumulate in spleens from chronically HIV-infected patients but barely participate in interferon-  expression

(2009) M. Nascimbeni et al.   BLOOD

Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients

(2009) G. Stary et al.   BLOOD

A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model

(2009) S. Shimizu et al.   BLOOD

Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/γc−/−, Balb/c-Rag1−/−γc−/−, and C.B-17-scid/bg immunodeficient mice

(2009) Christin M. Lepus et al.   HUMAN IMMUNOLOGY

The analysis of the functions of human B and T cells in humanized NOD/shi-scid/γcnull (NOG) mice (hu-HSC NOG mice)

(2009) Yohei Watanabe et al.   INTERNATIONAL IMMUNOLOGY

Priming of protective T cell responses against virus-induced tumors in mice with human immune system components

(2009) Till Strowig et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-7 Enhances Thymic Human T Cell Development in "Human Immune System" Rag2-/-IL-2R c-/- Mice without Affecting Peripheral T Cell Homeostasis

(2009) A. U. van Lent et al.   JOURNAL OF IMMUNOLOGY

Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice

(2009) D. M. Brainard et al.   JOURNAL OF VIROLOGY

Inability of Plasmacytoid Dendritic Cells To Directly Lyse HIV-Infected Autologous CD4+ T Cells despite Induction of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

(2009) J. Chehimi et al.   JOURNAL OF VIROLOGY

Evolution of the HIV-1 env Gene in the Rag2-/-  C-/- Humanized Mouse Model

(2009) W. L. Ince et al.   JOURNAL OF VIROLOGY

Nonpathogenesis of Simian Immunodeficiency Virus Infection Is Associated with Reduced Inflammation and Recruitment of Plasmacytoid Dendritic Cells to Lymph Nodes, Not to Lack of an Interferon Type I Response, during the Acute Phase

(2009) L. Campillo-Gimenez et al.   JOURNAL OF VIROLOGY

Suppression of Human Immunodeficiency Virus Type 1 (HIV-1) Viremia with Reverse Transcriptase and Integrase Inhibitors, CD4+ T-Cell Recovery, and Viral Rebound upon Interruption of Therapy in a New Model for HIV Treatment in the Humanized Rag2-/- c-/- Mouse

(2009) S. K. Choudhary et al.   JOURNAL OF VIROLOGY

RNAi-mediated CCR5 Silencing by LFA-1-targeted Nanoparticles Prevents HIV Infection in BLT Mice

(2009) Sang-Soo Kim et al.   MOLECULAR THERAPY

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts

(2009) Donald L Sodora et al.   NATURE MEDICINE

Sex differences in the Toll-like receptor–mediated response of plasmacytoid dendritic cells to HIV-1

(2009) Angela Meier et al.   NATURE MEDICINE

Dengue Virus Infection and Virus-Specific HLA-A2 Restricted Immune Responses in Humanized NOD-scid IL2rγnull Mice

(2009) Smita Jaiswal et al.   PLoS One

Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice

(2009) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functions and molecular mechanisms of the CD47–SIRPα signalling pathway

(2009) Takashi Matozaki et al.   TRENDS IN CELL BIOLOGY

Selective infection of CD4+ effector memory T lymphocytes leads to preferential depletion of memory T lymphocytes in R5 HIV-1-infected humanized NOD/SCID/IL-2Rγnull mice

(2009) Chuanyi Nie et al.   VIROLOGY

Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology

(2008) S. Baenziger et al.   BLOOD

FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/- C-/- mice in vivo

(2008) Q. Jiang et al.   BLOOD

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice

(2008) Priti Kumar et al.   CELL

Non-obese diabetic-recombination activating gene-1 (NOD-Rag 1null) interleukin (IL)-2 receptor common gamma chain (IL 2 rγnull) null mice: a radioresistant model for human lymphohaematopoietic engraftment

(2008) T. Pearson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Regulatory T cells in human immunodeficiency virus-infected patients are elevated and independent of immunological and virological status, as well as initiation of highly active anti-retroviral therapy

(2008) J. C. Gaardbo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Increased levels of regulatory T cells (Tregs) in human immunodeficiency virus-infected patients after 5 years of highly active anti-retroviral therapy may be due to increased thymic production of naive Tregs

(2008) L. Kolte et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Plasmacytoid Dendritic Cells Count in Antiretroviral-Treated Patients is Predictive of HIV Load Control Independent of CD4+ T-Cell Count

(2008) Claudio Mastroianni et al.   CURRENT HIV RESEARCH

Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2-/-γc-/-) mouse model

(2008) O ter Brake et al.   GENE THERAPY

Foxp3 and Treg cells in HIV-1 infection and immuno-pathogenesis

(2008) Derek Holmes et al.   IMMUNOLOGIC RESEARCH

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation

(2008) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nonhuman primate models of NeuroAIDS

(2008) Rachel Williams et al.   JOURNAL OF NEUROVIROLOGY

Type I interferon-dependent gene MxA in perinatal HIV-infected patients under antiretroviral therapy as marker for therapy failure and blood plasmacytoid dendritic cells depletion

(2008) Raffaele Badolato et al.   Journal of Translational Medicine

RAG2-/- c-/- Mice Transplanted with CD34+ Cells from Human Cord Blood Show Low Levels of Intestinal Engraftment and Are Resistant to Rectal Transmission of Human Immunodeficiency Virus

(2008) U. Hofer et al.   JOURNAL OF VIROLOGY

Preservation of FoxP3+ Regulatory T Cells in the Peripheral Blood of Human Immunodeficiency Virus Type 1-Infected Elite Suppressors Correlates with Low CD4+ T-Cell Activation

(2008) A. J. Chase et al.   JOURNAL OF VIROLOGY

Immunology in China: the past, present and future

(2008) Xuetao Cao   NATURE IMMUNOLOGY

Effect of transcription peptide inhibitors on HIV-1 replication

(2008) Rachel Van Duyne et al.   VIROLOGY

Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2−/−γc−/− (RAG-hu) mice

(2008) Bradford K. Berges et al.   VIROLOGY

Antiretroviral Pre-exposure Prophylaxis Prevents Vaginal Transmission of HIV-1 in Humanized BLT Mice

(2008) Paul W Denton et al.   PLOS MEDICINE

Regulatory T cells in HIV infection: Who’s suppressing what?

(2008) Nabila Seddiki et al.   Current HIV/AIDS Reports