Anakinra and Tocilizumab Enhance Survival and Function of Human Islets during Culture: Implications for Clinical Islet Transplantation

Human Islets Express a Marked Proinflammatory Molecular Signature Prior to Transplantation

(2012) Mark J. Cowley et al.   CELL TRANSPLANTATION

Fresh Islets are more Effective for Islet Transplantation than Cultured Islets

(2012) Hirofumi Noguchi et al.   CELL TRANSPLANTATION

The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways

(2012) E. Favaro et al.   DIABETOLOGIA

Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction

(2012) Unni Krishna S.R.L. Samavedam et al.   JOURNAL OF AUTOIMMUNITY

CXCR1/2 inhibition enhances pancreatic islet survival after transplantation

(2012) Antonio Citro et al.   JOURNAL OF CLINICAL INVESTIGATION

Analysis of Beta-Cell Gene Expression Reveals Inflammatory Signaling and Evidence of Dedifferentiation following Human Islet Isolation and Culture

(2012) Sarita Negi et al.   PLoS One

Anakinra Potentiates the Protective Effects of Etanercept in Transplantation of Marginal Mass Human Islets in Immunodeficient Mice

(2011) M. McCall et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Improving Efficacy of Clinical Islet Transplantation with Iodixanol-Based Islet Purification, Thymoglobulin Induction, and Blockage of IL-1β and TNF-α

(2011) Shinichi Matsumoto et al.   CELL TRANSPLANTATION

Interleukin-6 treatment induces beta-cell apoptosis via STAT-3-mediated nitric oxide production

(2011) Yoon Sin Oh et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

(2011) Hainan Chen et al.   NATURE

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

MEK–ERK pathway regulates EZH2 overexpression in association with aggressive breast cancer subtypes

(2011) S Fujii et al.   ONCOGENE

Improvement of HbA1c during treatment with humanised anti-interleukin 6 receptor antibody, tocilizumab

(2010) A. Ogata et al.   ANNALS OF THE RHEUMATIC DISEASES

Tocilizumab for the treatment of rheumatoid arthritis

(2010) Toshio Tanaka et al.   Expert Review of Clinical Immunology

Adiponectin-induced ERK and Akt Phosphorylation Protects against Pancreatic Beta Cell Apoptosis and Increases Insulin Gene Expression and Secretion

(2010) Nadeeja Wijesekara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Averting inflammation by targeting the cytokine environment

(2010) Manfred Kopf et al.   NATURE REVIEWS DRUG DISCOVERY

Blockade of interleukin 1 in type 1 diabetes mellitus

(2010) Thomas Mandrup-Poulsen et al.   Nature Reviews Endocrinology

A New Oxygen Carrier for Improved Long-Term Storage of Human Pancreata Before Islet Isolation

(2010) Heide Brandhorst et al.   TRANSPLANTATION

Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

(2009) C. M. Larsen et al.   DIABETES CARE

IL-1β receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis

(2009) Alice Schwarznau et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Short-Term Modulation of Extracellular Signal-Regulated Kinase 1/2 and Stress-Activated Protein Kinase/c-Jun NH2-Terminal Kinase in Pancreatic Islets by Glucose and Palmitate

(2009) Tatiane C.A. Nogueira et al.   PANCREAS

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

(2009) J. A. Ehses et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy Comparison Between Intraportal and Subcapsular Islet Transplants in a Murine Diabetic Model

(2009) N. Sakata et al.   TRANSPLANTATION PROCEEDINGS

Glucocorticoids reduce pro-inflammatory cytokines and tissue factorin vitroand improve function of transplanted human isletsin vivo

(2008) Tormod Lund et al.   TRANSPLANT INTERNATIONAL