Article
Endocrinology & Metabolism
Laurianne Bonnet, Ida Alexandersson, Ritesh K. K. Baboota, Tobias Kroon, Jan Oscarsson, Ulf Smith, Jeremie Boucher
Summary: Cellular senescence plays a causal role in the development of non-alcoholic steatohepatitis (NASH) by modulating glucose and lipid metabolism, favoring hepatic steatosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Xiaoying Luo, Yangqiu Bai, Shuli He, Suofeng Sun, Xiaoke Jiang, Zhiyu Yang, Di Lu, Peiru Wei, Yuan Liang, Cong Peng, Yaru Wang, Ruli Sheng, Shuangyin Han, Xiuling Li, Bingyong Zhang
Summary: In this study, it was found that oxidative stress triggered premature senescence in HSECs during CCl4-induced liver fibrogenesis, but overexpression of SIRT1 alleviated premature senescence and maintained fenestrae in HSECs to attenuate liver fibrogenesis.
CELL PROLIFERATION
(2021)
Article
Cell Biology
Bai Ruan, Juan-Li Duan, Hao Xu, Kai-Shan Tao, Hua Han, Guo-Rui Dou, Lin Wang
Summary: Liver sinusoidal endothelial cells undergo partial endothelial mesenchymal transition during liver fibrosis, leading to increased extracellular matrix production without activating cell mobility. Targeting this transitional process may be valuable for antifibrotic treatment of liver fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kaori Suzuki, Etsuo A. Susaki, Isao Nagaoka
Summary: This review discusses the roles of cellular senescence and bacterial infection in the pathogenesis of atherosclerosis. The study finds that bacterial infections and cellular senescence occur at the sites of atherosclerotic lesions, and lipopolysaccharide from Gram-negative bacteria can induce and enhance cellular senescence and the associated inflammatory properties, thus contributing to the development of atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Hye-Ram Jo, Jae-Hoon Jeong
Summary: This study reveals the crucial regulatory role of high mobility group box 2 (HMGB2) in cellular senescence. HMGB2 expression decreases with age, and its downregulation inhibits cell proliferation and accelerates cellular senescence, while overexpression delays senescence and maintains normal cellular function.
Article
Biochemistry & Molecular Biology
Atsuya Tsuru, Mikihiro Yoshie, Junya Kojima, Ryo Yonekawa, Mana Azumi, Kazuya Kusama, Hirotaka Nishi, Kazuhiro Tamura
Summary: PGRMC1 is involved in cellular senescence during decidualization through the regulation of FOXO1 expression.
Review
Gastroenterology & Hepatology
Jordi Gracia-Sancho, Esther Caparros, Anabel Fernandez-Iglesias, Ruben Frances
Summary: Liver sinusoidal endothelial cells (LSECs) play crucial roles in hepatic homeostasis, being involved in regulation of vascular tone, inflammation, and thrombosis, as well as control of the hepatic immune response. Dysregulations of LSECs in the context of liver disease and hepatocellular carcinoma make them potential therapeutic targets.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Peripheral Vascular Disease
Zachary S. Clayton, Matthew J. Rossman, Sophia A. Mahoney, Ravinandan Venkatasubramanian, Grace S. Maurer, David A. Hutton, Nicholas S. Vandongen, Nathan T. Greenberg, Abigail G. Longtine, Katelyn R. Ludwig, Vienna E. Brunt, Thomas J. Larocca, Judith Campisi, Simon Melov, Douglas R. Seals
Summary: Cellular senescence and the senescence associated secretory phenotype (SASP) contribute to vascular aging, and clearance of senescent cells holds promise for improving age-related vascular function.
Review
Cell Biology
Yoshiya Ito, Kanako Hosono, Hideki Amano
Summary: The liver has the ability to regenerate in response to acute liver injury, but liver ischemia-reperfusion injury (IRI) remains a major problem in liver surgery. Non-parenchymal cells in the liver play critical roles in liver repair and regeneration, and recent technological advances have provided insights into their heterogeneity. This review discusses the progress in understanding the biology of liver non-parenchymal cells and the functional role of each cell component in response to liver IRI.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Stephanie Simoncini, Simon Toupance, Carlos Labat, Sylvie Gautier, Chloe Dumoulin, Laurent Arnaud, Maria G. Stathopoulou, Sophie Visvikis-Siest, Pascal M. Rossi, Athanase Benetos, Francoise Dignat-George, Florence Sabatier
Summary: This study investigates the relationship between atherosclerotic cardiovascular disease (ASCVD), inflammation markers, and circulating endothelial progenitor cells. The findings suggest that ASCVD impairs the colony forming capacity and angiogenic properties of endothelial colony forming cells (ECFC) in a severity-dependent manner. Additionally, alteration of ECFC is associated with increased senescent phenotype and IL-6 levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Tingting Su, Yilin Yang, Sanchuan Lai, Jain Jeong, Yirang Jung, Matthew McConnell, Teruo Utsumi, Yasuko Iwakiri
Summary: This study mapped the spatial distribution and transcriptomic changes of liver sinusoidal endothelial cells (LSECs) in normal vs cirrhotic mouse livers, providing insights into the pathogenesis of liver cirrhosis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Peripheral Vascular Disease
Philipp-Sebastian Koch, Ki Hong Lee, Sergij Goerdt, Hellmut G. Augustin
Summary: 'Angiodiversity' refers to the structural and functional heterogeneity of endothelial cells along the vascular tree and in different organs, with LSEC in the liver being an example of organ-specific endothelial cells. Recent advances in molecular profiling have allowed for the identification of distinct LSEC subpopulations, revealing their role in regulating vascular tone and modulating immune responses. The discovery of LSEC-derived angiocrine signals has revolutionized our understanding of liver function in health and disease.
Article
Biochemistry & Molecular Biology
Jacopo Pieroni, Yuto Yamazaki, Xin Gao, Yuta Tezuka, Hiroko Ogata, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hironobu Sasano
Summary: The study revealed that in aldosterone-producing adenomas and idiopathic hyperaldosteronism, cells in the zona glomerulosa exhibited significantly higher levels of senescence compared to other regions. Additionally, laboratory findings of primary aldosteronism were significantly correlated with specific gene mutations.
Article
Cell Biology
Yongdae Yoon, Seong Chan Gong, Moon Young Kim, Soon Koo Baik, Ju-Eun Hong, Ki-Jong Rhee, Hoon Ryu, Young Woo Eom
Summary: Liver organoids generated using cell lines Huh-7, macrophages, LX-2 hepatic stellate cells, and primary liver sinusoidal endothelial cells were found to have increased expression of hepatocyte, LSEC, macrophage, and HSC-related genes compared to 2D-cultured cells. TAA treatment induced fibrotic and inflammatory responses in the liver organoids, which could be suppressed by N-acetyl-L-cysteine or tumor-necrosis-factor-stimulated gene 6 protein treatment.
Article
Cell Biology
Gabriella Teti, Francesca Chiarini, Eleonora Mazzotti, Alessandra Ruggeri, Francesco Carano, Mirella Falconi
Summary: Cellular senescence plays a key role in the development of age-related diseases, including abdominal aortic aneurysm (AAA). Understanding the molecular mechanisms behind the onset and development of AAA is still limited, with no pharmacological therapies currently available.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Kei Saito, Tohru Fujiwara, Shunsuke Hatta, Masanobu Morita, Koya Ono, Chie Suzuki, Noriko Fukuhara, Yasushi Onishi, Yukio Nakamura, Shin Kawamata, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae
MOLECULAR AND CELLULAR BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Jennifer E. Chung, Wendy Magis, Jonathan Vu, Seok-Jin Heo, Kirmo Wartiovaara, Mark C. Walters, Ryo Kurita, Yukio Nakamura, Dario Boffelli, David I. K. Martin, Jacob E. Corn, Mark A. Dewitt
Article
Multidisciplinary Sciences
Adam C. Wilkinson, Reiko Ishida, Misako Kikuchi, Kazuhiro Sudo, Maiko Morita, Ralph Valentine Crisostomo, Ryo Yamamoto, Kyle M. Loh, Yukio Nakamura, Motoo Watanabe, Hiromitsu Nakauchi, Satoshi Yamazaki
Article
Cell & Tissue Engineering
Mika Suga, Takayuki Kondo, Keiko Imamura, Ran Shibukawa, Yasue Okanishi, Yukako Sagara, Kayoko Tsukita, Takako Enami, Mahoko Furujo, Kaoru Saijo, Yukio Nakamura, Mitsujiro Osawa, Megumu K. Saito, Shinya Yamanaka, Haruhisa Inoue
STEM CELL RESEARCH
(2019)
Article
Genetics & Heredity
Falak Sher, Mir Hossain, Davide Seruggia, Vivien A. C. Schoonenberg, Qiuming Yao, Paolo Cifani, Laura M. K. Dassama, Mitchel A. Cole, Chunyan Ren, Divya S. Vinjamur, Claudio Macias-Trevino, Kevin Luk, Connor McGuckin, Patrick G. Schupp, Matthew C. Canver, Ryo Kurita, Yukio Nakamura, Yuko Fujiwara, Scot A. Wolfe, Luca Pinello, Takahiro Maeda, Alex Kentsis, Stuart H. Orkin, Daniel E. Bauer
Article
Cell Biology
Naoki Tanimizu, Norihisa Ichinohe, Hiromu Suzuki, Toshihiro Mitaka
Article
Multidisciplinary Sciences
Naoki Tanimizu, Norihisa Ichinohe, Yasushi Sasaki, Tohru Itoh, Ryo Sudo, Tomoko Yamaguchi, Takeshi Katsuda, Takafumi Ninomiya, Takashi Tokino, Takahiro Ochiya, Atsushi Miyajima, Toshihiro Mitaka
Summary: The study reports the generation of a hepatobiliary tubular organoid (HBTO) using mouse hepatocyte progenitors and cholangiocytes, which can reproduce the functional connection between hepatocytes and cholangiocytes in liver tissue.
NATURE COMMUNICATIONS
(2021)
Article
Cell & Tissue Engineering
Norihisa Ichinohe, Masayuki Ishii, Naoki Tanimizu, Toru Mizuguchi, Yusuke Yoshioka, Takahiro Ochiya, Hiromu Suzuki, Toshihiro Mitaka
Summary: The study found that miR-146a-5p in EVs produced by BM-MCs may play a major role in accelerating liver regeneration by activating intrinsic hepatocytic progenitor cells.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Norihisa Ichinohe, Naoki Tanimizu, Keisuke Ishigami, Yusuke Yoshioka, Naoki Fujitani, Takahiro Ochiya, Motoko Takahashi, Toshihiro Mitaka
Summary: This study found that transplantation of -Thy1(+) cells isolated from rats treated with d-galactosamine can promote SHPC expansion and liver regeneration. This is achieved through the secretion of extracellular vesicles (EVs) by -Thy1(+) cells that induce sinusoidal endothelial cells and Kupffer cells to secrete IL17B and IL25, respectively, thereby activating SHPCs via IL17RB signaling. In addition, miR-199a-5p, CINC-2, and MCP-1 in the Thy1(-) cell-derived EVs are potential factors promoting SHPC growth.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Gastroenterology & Hepatology
Junichi Kino, Norihisa Ichinohe, Masayuki Ishii, Hiromu Suzuki, Toru Mizuguchi, Naoki Tanimizu, Toshihiro Mitaka
HEPATOLOGY COMMUNICATIONS
(2020)
Proceedings Paper
Engineering, Biomedical
Yuan-Hsiang Chang, Kuniya Abe, Hideo Yokota, Kazuhiro Sudo, Yukio Nakamura, Slo-Li Chu, Chih-Yung Hsu, Ming-Dar Tsai
2019 41ST ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2019)
Meeting Abstract
Biotechnology & Applied Microbiology
Abhirup Bagchi, R. V. Shaji, Mohankumar Kumarasamypet Murugesan, Yukio Nakamura, H. Trent Spencer, Alok Srivastava