Article
Developmental Biology
Shannon M. Henry, Yi Xie, Katherine R. Rollins, J. Todd Blankenship
Summary: In the early syncytial Drosophila embryo, the formation and remodeling of cortical and furrow morphologies are driven by rapid changes in filamentous actin networks and membrane trafficking pathways. The DOCK protein Sponge plays a crucial role in the formation of transient membrane furrows and regulates a diverse cohort of Arp2/3 regulatory proteins. Furthermore, Rac GTPase activity may bridge Sponge regulation to the regulators of Arp2/3 function. Branching and linear actin networks have distinct roles in promoting furrow ingression.
DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tian Gan, Lixia Fan, Long Zhao, Mala Misra, Min Liu, Min Zhang, Ying Su
Summary: The evolutionarily conserved JNK signaling pathway is essential in determining longevity, with varying effects on lifespan depending on tissue/organ-specific manipulation in Drosophila. Recent studies have shed light on the molecular mechanisms underlying the tissue-specific effects of JNK activity, highlighting the comprehensive role of JNK signaling in regulating lifespan in fruit flies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shuo Yang, Xiaoqin Tang, Long Wang, Chengyang Ni, Yuesong Wu, Ling Zhou, Yueying Zeng, Chunling Zhao, Anguo Wu, Qiaozhi Wang, Xiyan Xu, Yiwei Wang, Rong Chen, Xiao Zhang, Lile Zou, Xinwu Huang, Jianming Wu
Summary: This study found that Ruxolitinib can promote MK differentiation and thrombocytopoiesis, which may alleviate radiation-injured thrombocytopenia. The potential mechanism of action is to activate the Rac1/cdc42/JNK pathway through binding to TLR2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Fangyu Song, Wenshuo Zhang, Xiaohui Li, Xiaoqing Chen, Xuejun Yuan, Mingjin Jiang, Yunhe Zhao, Qingxin Liu, Zizhang Zhou
Summary: The main cause of high mortality in cancer patients is tumor metastasis, and exploring the underlying mechanism of tumor metastasis is important for clinical treatments. This study identifies the transcription factor Apt/FSBP as a suppressor for tumor metastasis, providing it as a potential drug target for tumor treatment.
Article
Pharmacology & Pharmacy
La Yan, Juanyu Zhou, Lu Yuan, Jinbao Ye, Xudong Zhao, Gang Ren, Haiyang Chen
Summary: Silibinin effectively relieves intestinal inflammation and inhibits the overproliferation of intestinal stem cells in Drosophila via modulating the JNK signaling pathway. It also protects intestinal barrier function, reduces reactive oxygen species levels and inflammatory stress, and extends lifespan.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Sijia Liu, Lina Gu, Nan Wu, Jiayu Song, Jiazhuo Yan, Shanshan Yang, Yue Feng, Zhao Wang, Le Wang, Yunyan Zhang, Yan Jin
Summary: The study revealed that overexpression of DTL has an unfavorable prognostic implication for patients with cervical adenocarcinoma by enhancing cell motility and promoting tumor metastasis through the RAC1-JNK-FOXO1 axis, making it a potential therapeutic target for anti-tumor metastasis of cervical adenocarcinoma.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Tian Wei, Lei Wu, Xiaowen Ji, Yan Gao, Guiran Xiao
Summary: Ursolic acid (UA), a bioactive molecule found in fruits and vegetables, has therapeutic potential in ulcerative colitis (UC) induced by toxic chemicals. In this study, using a Drosophila UC model, the protective effect of UA on intestinal damage induced by sodium dodecyl sulfate (SDS) was investigated. The results showed that UA could protect against SDS-induced damage by reducing oxidative stress and restoring the activity of antioxidant enzymes. Additionally, UA inhibited the excessive activation of the JNK-dependent JAK/STAT signaling pathway. These findings suggest that UA has potential for the development of functional food or natural medicine for UC.
Article
Engineering, Marine
Jens Emil Walmsness, Hakon Hagen Helgesen, Stefan Larsen, Giorgio Kwame Minde Kufoalor, Tor Arne Johansen
Summary: This paper proposes and demonstrates an automatic steering system for passenger ferries with dock-to-dock capabilities. The method utilizes a modular control architecture and bumpless transfer transition strategies to allow different controllers for different vessel operational phases. A state machine divides ferry operations into undocking, transit, and docking phases. Simulation results show successful implementation of the method in ferry navigation between docks.
Article
Multidisciplinary Sciences
Jung-Wan Mok, Kwang-Wook Choi
Summary: The N-terminal acetyltransferase Mnat9 plays a crucial role in regulating cell signaling and microtubule stability in Drosophila, with its loss causing severe developmental defects. Mnat9 is associated with mitotic spindles, enhances microtubule stability, and protects microtubules from severing protein Spastin. Additionally, it is functionally conserved across species, as human NAT9 can rescue Mnat9 RNAi phenotypes in flies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Xiuqing Huang, Guang Yang, Li Zhao, Huiping Yuan, Hao Chen, Tao Shen, Weiqing Tang, Yong Man, Jiarui Ma, Yanyan Ma, Lin Dou, Jian Li
Summary: The study identified PP4 as a new regulator of hepatocyte lipoapoptosis. Inhibition of PP4 reduced SFA-induced JNK activation and expression of key modulators of lipoapoptosis, leading to decreased hepatocyte lipoapoptosis both in vitro and in vivo. PP4 was found to mediate hepatocyte lipoapoptosis by regulating the RAC1/MLK3/JNK signaling pathway.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Entomology
Jiewei Wang, Qiang Liu, Yuan Gong, Li Hua Jin
Summary: The adult Drosophila intestinal epithelium is tightly regulated by the G protein-coupled receptor Anchor to maintain homeostasis. Inactivation of anchor leads to aberrant activation of the JNK and Notch pathways, affecting stem cell differentiation and proliferation, ultimately causing sensitivity to environmental challenges.
JOURNAL OF INSECT PHYSIOLOGY
(2021)
Article
Environmental Sciences
Leonard Clinton D'Souza, Shiwangi Dwivedi, Faiza Raihan, Undiganalu Gangadharappa Yathisha, Shamprasad Varija Raghu, Bangera Sheshappa Mamatha, Anurag Sharma
Summary: This study investigates the relationship between benzene-induced immune dysfunction and developmental toxicity in a genetically tractable animal model. It also explores the protective role of Hsp70 against benzene-induced immunotoxicity and developmental impact.
ENVIRONMENTAL TOXICOLOGY
(2022)
Review
Cell Biology
Abhinava K. Mishra, Vartika Sharma, Mousumi Mutsuddi, Ashim Mukherjee
Summary: Multicellular organisms rely on core signaling pathways to regulate cell fate choices, which integrate to form complex networks for distinct developmental outcomes. Notch pathway, a conserved mechanism, interacts with other pathways to produce context-dependent outputs, and understanding its crosstalk with JNK and NF-KB pathways is crucial for regulating various developmental events.
CELLULAR SIGNALLING
(2021)
Article
Genetics & Heredity
Luchi Farrell, Aleix Puig-Barbe, Md Iqramul Haque, Alla Amcheslavsky, Mengyuan Yu, Andreas Bergmann, Yun Fan
Summary: Stress-induced cell death, mainly apoptosis, and the subsequent tissue repair are interlinked through the mechanism of apoptosis-induced proliferation (AiP). Caspases and JNK signaling play critical roles in activating AiP. Furthermore, F-actin remodeling mediated by LIMK1 plays an important role in caspase-driven ROS production and JNK activation in the process of AiP.
Article
Genetics & Heredity
Bojie Cong, Mai Nakamura, Yukari Sando, Takefumi Kondo, Shizue Ohsawa, Tatsushi Igaki
Summary: Identifying a common oncogenesis pathway among tumors with different oncogenic mutations is critical for developing anti-cancer strategies. Using fruit fly Drosophila as a model organism, researchers discovered a common oncogenesis pathway in malignant tumors and suppressed their growth using LAT1 inhibitors.
Article
Oncology
Saki Shimada, Yuuka Muraoka, Kimihide Ibaraki, Toshiyuki Takano-Shimizu-Kouno, Hideki Yoshida, Masamitsu Yamaguchi
EXPERIMENTAL CELL RESEARCH
(2020)
Article
Oncology
Ibuki Ueoka, Akari Takai, Mizuki Yamaguchi, Tomohiro Chiyonobu, Hideki Yoshida, Masamitsu Yamaguchi
EXPERIMENTAL CELL RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Masamitsu Yamaguchi, Kentaro Omori, Satoshi Asada, Hideki Yoshida
Summary: ALS and CMT are common neurodegenerative disorders with significant phenotypic heterogeneity, potentially due to modifiers that influence disease characteristics. Epigenetic regulation of biological functions through gene expression may be an important mechanism in these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Eric Hyrmeya Savadogo, Yui Shiomi, Junko Yasuda, Toshiharu Akino, Masamitsu Yamaguchi, Hideki Yoshida, Takanari Umegawachi, Ryo Tanaka, Dang Ngoc Anh Suong, Kenji Miura, Kazufumi Yazaki, Sakihito Kitajima
Summary: Genes of the PLAT protein family play a role in plant defense against insects through the involvement of anti-microbe or anti-insect proteins in laticifer cells. These genes induce an indirect insect resistance response in the host plant, as well as possibly causing direct cytotoxic effects on insects. Larval growth of insects is significantly affected by the expression of PLAT proteins from different plant species, highlighting the conserved anti-insect activity of the PLAT protein family in the plant kingdom.
Article
Biochemistry & Molecular Biology
Hang Thi Nguyet Pham, Hong Nguyen Tran, Xoan Thi Le, Ha Thi Do, Tue Trong Nguyen, Chien Le Nguyen, Hideki Yoshida, Masamistu Yamaguchi, Folk R. William, Kinzo Matsumoto
Summary: This study found that a chemically characterized extract from Ilex kudingcha can improve behavioral traits in a Drosophila melanogaster rugose mutant, resembling human Autism Spectrum Disorder (ASD) traits. The extract also increased synaptic bouton number in Drosophila rugose and altered gene expression in the mouse hippocampus. These results suggest the potential of Ilex kudingcha extract as a treatment for some forms of ASD.
NEUROCHEMICAL RESEARCH
(2021)
Article
Neurosciences
Yuuka Muraoka, Atsushi Nikaido, Ryosuke Kowada, Hiroshi Kimura, Masamitsu Yamaguchi, Hideki Yoshida
Summary: Mutations in the FIG 4 gene are associated with various disorders, possibly due to dysregulated epigenetics. HDAC1 has been identified as an important epigenetic regulator of FIG 4, suggesting potential therapeutic targets for FIG 4-related disorders such as CMT.
Correction
Oncology
Hisanori Matsubara, Reiji Tanaka, Tatsuya Tateishi, Hideki Yoshida, Masamitsu Yamaguchi, Takao Kataoka
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Oncology
Masamitsu Yamaguchi, Im-soon Lee, Salinee Jantrapirom, Kojiro Suda, Hideki Yoshida
Summary: Drosophila is being used as a model for studying human diseases, with functional homologues of a large percentage of human disease-related genes found in Drosophila. This review discusses Drosophila models targeting genes associated with ALS and CMT, highlighting potential therapeutic targets and diagnostic markers.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Ngoc-Lan Thi Nguyen, Ngoc-Dzung Thi Dang, Quang-Huy Dang, Van-Chuc Tran, Hoang-Long Vo, Masamitsu Yamaguchi, Thanh-Van Ta
Summary: The study found that the polymorphisms of Mucin 1 gene, specifically rs4072037 and rs2070803, are associated with gastric cancer risk, with the AA genotype potentially increasing risk while the AG genotype may lower it. Combining factors such as age, gender, alcoholism, and personal history of gastric disease significantly elevate the risk of gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Ryosuke Kowada, Atsushi Kodani, Hiroyuki Ida, Masamitsu Yamaguchi, Im-Soon Lee, Yasushi Okada, Hideki Yoshida
Summary: The homolog of human SCO2, Scox, plays an essential role in mitochondrial function and locomotive behavior in Drosophila. Knockdown of Scox in glial cells impairs mitochondrial morphology and function, as well as locomotive behavior, mimicking the pathological phenotypes observed in humans with mutations in the SCO2 gene.
SCIENTIFIC REPORTS
(2021)
Correction
Multidisciplinary Sciences
Tomoki Hirashima, Ryo Tanaka, Masamitsu Yamaguchi, Hideki Yoshida
SCIENTIFIC REPORTS
(2021)
Editorial Material
Biochemistry & Molecular Biology
Masamitsu Yamaguchi, Shinya Yamamoto
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Yu Hiramatsu, Yuji Okamoto, Akiko Yoshimura, Jun-Hui Yuan, Masahiro Ando, Yujiro Higuchi, Akihiro Hashiguchi, Eiji Matsuura, Fumihito Nozaki, Tomohiro Kumada, Kei Murayama, Mikiya Suzuki, Yuki Yamamoto, Naoko Matsui, Yoshimichi Miyazaki, Masamitsu Yamaguchi, Youji Suzuki, Jun Mitsui, Hiroyuki Ishiura, Masaki Tanaka, Shinichi Morishita, Ichizo Nishino, Shoji Tsuji, Hiroshi Takashima
Summary: This study identified causative mutations in mitochondrial-related nuclear genes in suspected hereditary peripheral neuropathy patients. Whole-exome sequencing was performed on a large cohort of Japanese patients, and novel pathogenic variants were detected in four mitochondrial-related nuclear genes. These patients exhibited sensory and motor axonal polyneuropathy, along with central nervous system or multisystem involvements.
JOURNAL OF NEUROLOGY
(2022)
Correction
Biochemistry & Molecular Biology
Ibuki Ueoka, Hang Thi Nguyet Pham, Kinzo Matsumoto, Masamitsu Yamaguchi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Integrative & Complementary Medicine
Patcharin Phokasem, Salinee Jantrapirom, Jirarat Karinchai, Hideki Yoshida, Masamitsu Yamaguchi, Panuwan Chantawannakul
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2020)
