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Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
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Immunology
Junyi Tan, Jing Luo, Changchang Meng, Ning Jiang, Jing Cao, Jing Zhao
Summary: Syringin demonstrated a protective effect against brain ischemia/reperfusion injury in rats, reducing inflammation and acting through the FOXO3a/NF-kappa B pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
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Medicine, Research & Experimental
Zhenfei Ding, Ce Dai, Wenshan Shan, Rui Liu, Wei Lu, Weilu Gao, Hui Zhang, Wei Huang, Jianzhong Guan, Zongsheng Yin
Summary: Under inflammatory conditions, TNF-alpha activates Nanog expression in astrocytes through the NF-kappa B signaling pathway, leading to their dedifferentiation and acquisition of stem cell-like characteristics.
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Pharmacology & Pharmacy
Jiyuan Yan, Yingchi Zhang, Gaohong Sheng, Bowei Ni, Yifan Xiao, Shanxi Wang, Tianqi Wang, Yongzhuang Ma, Huaixi Wang, Hua Wu, Chang Tu
Summary: The study demonstrated that Selonsertib has anti-arthritic effects in rat OA by preventing inflammatory reactions, cartilage degradation, and cell apoptosis. The protective roles of Ser are mediated through the ASK1/P38/JNK and NFκB pathways. In addition, intra-articular injection of Ser significantly alleviated surgery-induced cartilage damage in the rat OA model.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kaifang Guan, He Li, Haoran Chen, Xiaofen Qi, Rongchun Wang, Ying Ma
Summary: The study demonstrates that MFG-E8 can alleviate oxidative stress-induced L6 cell damage by regulating multiple metabolic pathways, including carbon metabolism, glutathione metabolism, and mitochondria-mediated metabolic pathways.
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
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Geriatrics & Gerontology
Sugyeong Ha, Yejin Yang, Jeong Won Kim, Minjung Son, Doyeon Kim, Mi-Jeong Kim, Dong-Soon Im, Hae Young Chung, Ki Wung Chung
Summary: Aging kidneys exhibit increased vulnerability to folic acid-induced renal fibrosis. The diminished expression of farnesoid X receptor (FXR) in the epithelial cells of renal tubules exacerbates the fibrotic response and inflammation. FXR activation reduces NF-kappa B activation and chemokine production, while FXR knockdown enhances inflammation and fibrosis.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
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Cell Biology
Dianbo Long, Yiyang Xu, Guping Mao, Ruobing Xin, Zengfa Deng, Hongyi Liao, Zhiwen Li, Zhi Yang, Baoxi Yu, Zhijian Yang, Aishan He, Ziji Zhang, Yan Kang
Summary: tRNA-derived fragments (tRFs) have been shown to play important roles in cell metabolism by regulating gene expression. This study investigates the role of tRFs in the cellular metabolism of the anterior cruciate ligament (ACL). The findings reveal that TRF365 regulates ACL cell metabolism by targeting IKBKB.
CELL DEATH DISCOVERY
(2022)
Article
Environmental Sciences
Wenli Luo, Li Li, Weina Xu, Jing Zhang, Jianxiong Xu
Summary: Treatment of BRL-3A cells with DHA (50, 100, and 200 μM) for 24 hours promotes cell apoptosis and inflammatory response, with involvement of the p38 MAPK, ERK, and NF-kappa B signal pathways.
Article
Plant Sciences
Maria Sikorska, Malgorzata Dutkiewicz, Oliwia Zegrocka-Stendel, Magdalena Kowalewska, Iwona Grabowska, Katarzyna Koziak
Summary: The study demonstrates the beneficial role of beta-escin in muscle regeneration, especially in poorly regenerating slow-twitch muscles. The drug reduces inflammation, increases muscle fiber numbers, and decreases fibrosis. Additionally, beta-escin alters the transcription of muscle regeneration-related genes, promoting the recovery of injured muscles.
Article
Cell Biology
Shuangshuo Jia, Yue Yang, Yishu Bai, Yingliang Wei, He Zhang, Yicheng Tian, Jiabao Liu, Lunhao Bai
Summary: This study demonstrated that exercise-induced Irisin has anti-inflammatory and antipyroptosis effects on osteoarthritis chondrocytes. Moderate-intensity treadmill exercise increased the levels of Irisin, which recovered the expression of collagen II and attenuated the expression of inflammatory markers. Irisin achieved these effects by inhibiting the PI3K/Akt/NF-kappa B signaling pathway and inhibiting the activity of NLRP3/caspase-1. The findings suggest that Irisin could be a potential therapeutic target for osteoarthritis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Hong-Ying Yang, Weidong Yao, Pei-Zhi Huang, Hui Xu, Qian Ma, Xiaoming Chen, Jian-Jun Chen, Kun Gao
Summary: This study isolated three unreported ent-abietane-type norditerpene lactones, named euphohelides A-C (1-3), from the whole plants of Euphorbia helioscopia L. The structures of euphohelides A-C were established using spectroscopic methods, computational ECD, and X-ray crystallographic analyses. Euphohelide A (1) is a novel 2-nor-ent-abietane lactone with a unique 5/6/6/5 tetracyclic system.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Pharmacology & Pharmacy
Lei Tian, Jun Yan, Kang Li, Wei Zhang, Bencheng Lin, Wenqing Lai, Liping Bian, Huanliang Liu, Zhuge Xi, Xiaohua Liu
Summary: Ozone exposure causes dose- and gender-dependent lung injury, with males being more sensitive. Increasing ozone concentrations lead to inflammation and pulmonary edema.
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Pharmacology & Pharmacy
Xia Zhao, Shengchen Wang, Xiaojing Li, Honggui Liu, Shiwen Xu
Summary: Cadmium exposure induced necrotic cell death and ion homeostasis imbalance in swine myocardium. Furthermore, Cd exposure increased LXA4 content, inhibited FPR2 expression, activated TGF-beta pathway, suppressed Nrf2 pathway, and activated NF-kappa B pathway. Cd exposure also increased the expressions of necroptosis-related genes.
Article
Allergy
Roshini S. Abraham, Joanna M. Marshall, Hye Sun Kuehn, Cesar M. Rueda, Amber Gibbs, Will Guider, Claire Stewart, Sergio D. Rosenzweig, Huanyu Wang, Sophonie Jean, Mark Peeples, Tiffany King, W. Garrett Hunt, Jonathan R. Honegger, Octavio Ramilo, Peter J. Mustillo, Asuncion Mejias, Monica Ardura, Masako Shimamura
Summary: COVID-19, caused by SARS-CoV-2, can have a significant impact on the immune system. This study evaluated a novel NFKB2 loss of function variant in a 17-year-old male patient and discussed the clinical management of SARS-CoV-2 infection in this context. Despite underlying immune dysfunction, the patient recovered from the infection with intense management.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)