Ozone exposure promotes pyroptosis in rat lungs via the TLR2/4-NF-κB-NLRP3 signaling pathway

Glyburide attenuates ozone‐induced pulmonary inflammation and injury by blocking the NLRP3 inflammasome

(2020) Hua Shao et al.   ENVIRONMENTAL TOXICOLOGY

Oxidative Stress in Ozone-Induced Chronic Lung Inflammation and Emphysema: A Facet of Chronic Obstructive Pulmonary Disease

(2020) Coen H. Wiegman et al.   Frontiers in Immunology

Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses

(2019) Anastasiya Birukova et al.   TOXICOLOGICAL SCIENCES

17ß-estradiol affects lung function and inflammation following ozone exposure in a sex-specific manner

(2019) Nathalie Fuentes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Acute Respiratory Barrier Disruption by Ozone Exposure in Mice

(2019) Milena Sokolowska et al.   Frontiers in Immunology

Ozone Pollution: A Major Health Hazard Worldwide

(2019) Junfeng (Jim) Zhang et al.   Frontiers in Immunology

Hypoxia-Induced ROS Contribute to Myoblast Pyroptosis during Obstructive Sleep Apnea via the NF-κB/HIF-1α Signaling Pathway

(2019) Li-Ming Yu et al.   Oxidative Medicine and Cellular Longevity

The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury

(2018) Xintong Ge et al.   BRAIN RESEARCH

Pioglitazone Confers Neuroprotection Against Ischemia-Induced Pyroptosis due to its Inhibitory Effects on HMGB-1/RAGE and Rac1/ROS Pathway by Activating PPAR-ɤ

(2018) Pingping Xia et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Gasdermin D Flashes an Exit Signal for IL-1

(2018) Teneema Kuriakose et al.   IMMUNITY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study

(2018) Rudy Sinharay et al.   LANCET

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis

(2018) Xianxian Wu et al.   Cell Death & Disease

Sex Differences in Pulmonary Responses to Ozone in Mice: Role of the Microbiome

(2018) Youngji Cho et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Paricalcitol attenuates TGF-β1–induced phenotype transition of human peritoneal mesothelial cells (HPMCs) via modulation of oxidative stress and NLRP3 inflammasome

(2018) Jiyeon Ko et al.   FASEB JOURNAL

Targeting IL-33/ST2 signaling: regulation of immune function and analgesia

(2017) Victor Fattori et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Protective effect of pilose antler peptide on cerebral ischemia/reperfusion (I/R) injury through Nrf-2/OH-1/NF-κB pathway

(2017) Luning Bai et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inflammasome activation and assembly at a glance

(2017) Ankit Malik et al.   JOURNAL OF CELL SCIENCE

Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway

(2017) Jun Zeng et al.   Journal of Neuroinflammation

Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015

(2017) Aaron J Cohen et al.   LANCET

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

The optimal duration of ischemic preconditioning for renal ischemia-reperfusion injury in mice

(2017) Hyun Su Choi et al.   Annals of Surgical Treatment and Research

The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases

(2017) Carlos de Torre-Minguela et al.   Frontiers in Immunology

Mechanisms of the acute effects of inhaled ozone in humans

(2016) Philip A. Bromberg   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Pyroptosis

(2016) Lieselotte Vande Walle et al.   CURRENT BIOLOGY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Sex differences in the expression of lung inflammatory mediators in response to ozone

(2015) Noe Cabello et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Extracellular HMGB1 regulates multi-walled carbon nanotube-induced inflammationin vivo

(2014) Forrest Jessop et al.   Nanotoxicology

Soyasaponins Can Blunt Inflammation by Inhibiting the Reactive Oxygen Species-Mediated Activation of PI3K/Akt/NF-kB Pathway

(2014) Longying Zha et al.   PLoS One

NLRP3 Gene Silencing Ameliorates Diabetic Cardiomyopathy in a Type 2 Diabetes Rat Model

(2014) Beibei Luo et al.   PLoS One

The Role of TLR2 and 4-Mediated Inflammatory Pathways in Endothelial Cells Exposed to High Glucose

(2014) Harshini Mudaliar et al.   PLoS One

Partially-desulfated heparin improves survival inPseudomonaspneumonia by enhancing bacterial clearance and ameliorating lung injury

(2013) Lokesh Sharma et al.   Journal of Immunotoxicology

Penehyclidine hydrochloride inhibits the release of high-mobility group box 1 in lipopolysaccharide-activated RAW264.7 cells and cecal ligation and puncture–induced septic mice

(2013) Qiang Yang et al.   JOURNAL OF SURGICAL RESEARCH

An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies

(2013) Domenica Musumeci et al.   PHARMACOLOGY & THERAPEUTICS

Danger Signals Activating the Immune Response after Trauma

(2012) Stefanie Hirsiger et al.   MEDIATORS OF INFLAMMATION

Lung Cancer Incidence and Long-Term Exposure to Air Pollution from Traffic

(2011) Ole Raaschou-Nielsen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

HMGB1 activates nuclear factor-κB signaling by RAGE and increases the production of TNF-α in human umbilical vein endothelial cells

(2010) Zheng-Gang Luan et al.   IMMUNOBIOLOGY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of PAMPs and DAMPs in the pathogenesis of acute and recurrent anterior uveitis

(2009) D. Wakefield et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Sex differences in mortality in patients with COPD

(2008) J. P. de Torres et al.   EUROPEAN RESPIRATORY JOURNAL

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Long-Term Effects of Traffic-Related Air Pollution on Mortality in a Dutch Cohort (NLCS-AIR Study)

(2007) Rob Beelen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES