Review
Agriculture, Dairy & Animal Science
Anna B. Ruegg, Susanne E. Ulbrich
Summary: Embryonic diapause in mammals refers to the transient reduction of proliferation and developmental progression that occurs during the blastocyst stage. This phenomenon has been observed in at least 130 mammalian species, including the European roe deer. In roe deer, there is a peculiar phenomenon of reduced growth and slow development during early embryonic proliferation.
Article
Obstetrics & Gynecology
Kenji Ezoe, Tsubasa Takahashi, Kiyoe Shimazaki, Tetsuya Miki, Yuko Tanimura, Ayumi Amagai, Ayano Sawado, Hikari Akaike, Mai Mogi, Shigeru Kaneko, Mizuki Kato, Keiichi Kato, Nicoletta Tarozzi, Andrea Borini, Giovanni Coticchio
Summary: This study investigates the morphokinetic changes during abnormal fertilization using time-lapse technology. It finds that abnormal fertilization recapitulates the overall choreography of normal fertilization but also reveals novel morphokinetic phenomena. The findings raise scientifically and clinically relevant questions about the physiology and pathology of early human development.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Wen Luo, Yi-Min Zheng, Yan Hao, Ying Zhang, Ping Zhou, Zhaolian Wei, Yunxia Cao, Dawei Chen
Summary: The association between adjusted mtDNA levels in human trophectoderm biopsy samples and the developmental potential of euploid and mosaic blastocysts was investigated. Euploid embryos had lower mtDNA levels compared to aneuploid and mosaic embryos. Furthermore, factors such as maternal age and the specific DNA sequencing platform used had a significant effect on observed mtDNA content.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Arsalan, Adnan Haider, Se Woon Cho, Yu Hwan Kim, Kang Ryoung Park
Summary: Infertility is a global health concern, and in vitro fertilization (IVF) is an effective technique to address it. This study proposes a novel multiscale aggregation semantic segmentation network (MASS-Net) using deep learning to accurately detect the components of human blastocysts and achieve good segmentation performance.
Article
Multidisciplinary Sciences
Berna Sozen, Victoria Jorgensen, Bailey A. T. Weatherbee, Sisi Chen, Meng Zhu, Magdalena Zernicka-Goetz
Summary: In this study, expanded pluripotent stem cells were used to model early human embryo development, generating self-organizing cystic structures displaying early embryonic characteristics. While there are similarities in cell lineages, morphology, and signaling pathways, significant divergences from natural blastocysts persist. This method provides insights into the design of stem cell models for embryogenesis.
NATURE COMMUNICATIONS
(2021)
Article
Public, Environmental & Occupational Health
J. Coggon
Summary: This paper examines the relationship between the scientific and ethical aspects of public health, stating that public health has a political nature and aims to achieve ethical goals. While political outcomes are necessary for public health, individual members are not required to be directly involved in politics.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Fang Wang, David H. H. McCulloh, Kasey Chan, Ashley Wiltshire, Caroline McCaffrey, James A. A. Grifo, David L. Keefe
Summary: This study investigated the telomere length, telomerase gene expression, and telomerase activity in aneuploid blastocysts compared to euploid blastocysts. The results showed that aneuploid blastocysts had longer telomeres, higher TERT mRNA expression, and lower telomerase activity. The presence of telomerase and maintenance of telomeres in aneuploid blastocysts explain why extended in vitro culture alone is insufficient to eliminate aneuploid embryos during in vitro fertilization.
Article
Biochemical Research Methods
Yi Zheng, Yue Shao, Jianping Fu
Summary: This study presents a microfluidic device for modeling human embryo development, derived from human pluripotent stem cells. The resulting structures exhibit molecular and cellular features resembling early post-implantation human embryo development. The microfluidic model is compatible with high-throughput studies and various analytical techniques.
Article
Obstetrics & Gynecology
Giovanni Coticchio, Amy Barrie, Cristina Lagalla, Andrea Borini, Simon Fishel, Darren Griffin, Alison Campbell
Summary: Recent evidence from time-lapse technology and preimplantation genetic testing highlights the remarkable plasticity of human embryos in vitro, challenging current embryological notions and suggesting the need for new rules governing preimplantation development.
HUMAN REPRODUCTION UPDATE
(2021)
Article
Ethics
Francoise Baylis
Summary: The recently issued Guidelines for Stem Cell Research and Clinical Translation by ISSCR have made significant revisions, including dividing the prohibited research activities into currently not permitted and prohibited categories, as well as moving heritable human genome editing research from the prohibited category to the currently not permitted category. These changes may serve to pave the way for the eventual approval of currently prohibited research activities through specialized scientific and ethics review and approval.
JOURNAL OF MEDICAL ETHICS
(2023)
Article
Obstetrics & Gynecology
Giovanni Coticchio, Giulia Fiorentino, Giovanna Nicora, Raffaella Sciajno, Federica Cavalera, Riccardo Bellazzi, Silvia Garagna, Andrea Borini, Maurizio Zuccotti
Summary: This study explored the relationship between cytoplasmic movement and embryo development using artificial intelligence and image analysis. By monitoring cytoplasmic movement velocity and employing AI algorithms to classify embryo viability, the study successfully predicted blastocyst development based on early cleavage stages.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
P. Merviel, S. Bouee, A. S. Jacamon, J. J. Chabaud, M. T. Le Martelot, S. Roche, C. Rince, H. Drapier, A. Perrin, D. Beauvillard
Summary: The study found that blastocyst transfers were associated with higher clinical pregnancy and birth rates than cleaved embryo transfers in the general population but not in a selected population. Serum progesterone levels on the eve of the trigger day and on the day itself were predictive of the likelihood of pregnancy.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Endocrinology & Metabolism
Yuqiong Wang, Sheng Wang, Xilin Qian, Yanrong Kuai, Yang Xu
Summary: A single-center, large-cohort, retrospective study compared embryonic development in group culture systems with or without G4 embryos, revealing that multiple G4 embryos have a negative impact on neighboring embryos, while polypronuclear embryos contribute positively. LC-MS/MS analysis of G1-G4 embryo secretome showed that certain proteins secreted by G4 embryos may harm nearby embryos, emphasizing the importance of limiting the number of G4 embryos in group culture settings.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Doris Spinosa Cheles, Andre Satoshi Ferreira, Isabela Sueitt de Jesus, Eleonora Inacio Fernandez, Gabriel Martins Pinheiro, Eloiza Adriane Dal Molin, Wallace Alves, Rebeca Colauto Milanezi de Souza, Lorena Bori, Marcos Meseguer, Jose Celso Rocha, Marcelo Fabio Gouveia Nogueira
Summary: New techniques and equipment help evaluate embryo quality, but there is still subjectivity in classifications, image processing provides better analysis of embryos and generates variables describing different aspects of embryos.
APPLIED SCIENCES-BASEL
(2022)
Article
Obstetrics & Gynecology
Katerina Chatzimeletiou, Nikos Petrogiannis, Antonia Sioga, Elpida-Niki Emmanouil-Nikoloussi, Yannis Panagiotidis, Marialena Prapa, Antonios Patrikiou, Maria Filippa, Glykeria Zervakakou, Kyriakos Papanikolaou, Anastasios Makedos, Efstratios Kolibianakis, Basil C. Tarlatzis, Grigoris Grimbizis
Summary: There were no differences in spindle abnormalities or ultrastructure between embryos biopsied on day 5 and day 3, but higher numbers of abnormalities were observed following vitrification, including abnormal spindles, distended mitochondria, multivesicular bodies, lipofuscin droplets, altered cell junctions, and occasionally excessive accumulation of glycogen granules. The fresh day 3 biopsied group had a lower incidence of damaged cells compared to the fresh day 3+5 group and the vitrified day 5 group.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Biochemistry & Molecular Biology
Arjun Jain, Vidhi Mehrotra, Hannah Yong, Kirti Hiremath, Ashok Jain, Martin Johnson, Ira Jha
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2019)
Editorial Material
Obstetrics & Gynecology
Wybo Dondorp, Martin H. Johnson
REPRODUCTIVE BIOMEDICINE ONLINE
(2017)
Editorial Material
Obstetrics & Gynecology
Martin H. Johnson
REPRODUCTIVE BIOMEDICINE ONLINE
(2017)
Editorial Material
Obstetrics & Gynecology
Bart Fauser, Mina Alikani, Sarah Franklin, Martin H. Johnson, Juan Garcia-Velasco
REPRODUCTIVE BIOMEDICINE ONLINE
(2017)
Letter
Obstetrics & Gynecology
Mina Alikani, Bart C. J. Fauser, Juan Antonio Garcia-Valesco, Joe Leigh Simpson, Martin H. Johnson
REPRODUCTIVE BIOMEDICINE ONLINE
(2017)
Editorial Material
Obstetrics & Gynecology
Bart Fauser, Mina Alikani, Richard Anderson, Sarah Franklin, Martin H. Johnson, Juan Garcia Velasco
REPRODUCTIVE BIOMEDICINE ONLINE
(2018)
Letter
Obstetrics & Gynecology
Mina Alikani, Bart C. J. M. Fauser, Richard Anderson, Juan Antonio Garcia-Velasco, Martin Johnson
REPRODUCTIVE BIOMEDICINE ONLINE
(2018)
Editorial Material
Obstetrics & Gynecology
Sharyn Stock-Myer, Martin Johnson
REPRODUCTIVE BIOMEDICINE ONLINE
(2018)
Editorial Material
Obstetrics & Gynecology
P. R. Braude, M. H. Johnson
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2019)
Editorial Material
Obstetrics & Gynecology
Bart Fauser, Mina Alikani, Richard Anderson, Sarah Franklin, Martin H. Johnson, Juan Garcia Velasco
REPRODUCTIVE BIOMEDICINE ONLINE
(2019)
Article
Developmental Biology
Martin Johnson
Editorial Material
Obstetrics & Gynecology
Catherine Aiken, Martin Johnson
REPRODUCTIVE BIOMEDICINE ONLINE
(2019)
Review
Pharmacology & Pharmacy
Arjun Jain, Martin H. Johnson
DRUG DISCOVERY TODAY
(2020)
Article
Psychology, Multidisciplinary
Lydia Sefton-Minns, Martin H. Johnson
Summary: The British Government formed a committee to review anti-homosexuality laws in 1954 due to an increase in arrests for homosexuality after World War II. The committee asked the British Medical Association (BMA) and other institutions for scientific and medical evidence on homosexuality. In their submission, the BMA expressed support for decriminalizing certain homosexual acts but maintained a moral opposition and considered homosexuality an illness.
JOURNAL OF HOMOSEXUALITY
(2023)
Article
Developmental Biology
Martin H. Johnson
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2019)
