Article
Multidisciplinary Sciences
Andres Garcia-Garcia, Thibaut Klein, Gordian Born, Morgane Hilpert, Arnaud Scherberich, Claudia Lengerke, Radek C. Skoda, Paul E. Bourgine, Ivan Martin
Summary: Human malignant hematopoietic stem and progenitor cells reside in bone marrow niches, and in vitro systems have been developed to mimic these niches for studying leukemia and drug responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Eva M. Fast, Audrey Sporrij, Margot Manning, Edroaldo Lummertz Rocha, Song Yang, Yi Zhou, Jimin Guo, Ninib Baryawno, Nikolaos Barkas, David Scadden, Fernando Camargo, Leonard Zon
Summary: The article discusses the functions of adult stem cells and the effects of external signalling molecules on stem cells. The study reveals the rapid response of stem cells to external signals, with unique gene expression patterns affected by different chemicals. The results suggest that stem cells may be primed by low levels of external signalling molecules released from their microenvironment to better respond to future stress or injuries.
Review
Cell Biology
Daozheng Yang, Gerald de Haan
Summary: Hematopoietic stem cells (HSCs) play a crucial role in lifelong blood cell production. Aging impacts HSC function, with inflammation emerging as a key factor in driving this process. Both intrinsic and extrinsic factors contribute to HSC aging.
Review
Immunology
Carsten Riether
Summary: Adult bone marrow hematopoietic stem cells (HSCs) maintain their function through interactions with regulatory T cells (Tregs). In leukemia, these regulatory mechanisms are disrupted, leading to compromised treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Na Yuan, Wen Wei, Li Ji, Jiawei Qian, Zhicong Jin, Hong Liu, Li Xu, Lei Li, Chen Zhao, Xueqin Gao, Yulong He, Mingyuan Wang, Longhai Tang, Yixuan Fang, Jianrong Wang
Summary: The bone marrow niche, responsible for maintaining hematopoietic stem cell homeostasis, declines in function with aging and hematological malignancies. This study reveals that disrupting autophagy in HSCs accelerates niche aging, while transplantation of young donor HSCs repairs the niche environment. Further investigation shows that HSCs transdifferentiate into functional niche cells, including mesenchymal stromal cells and endothelial cells, in an autophagy-dependent manner. These findings provide a clinical solution to rejuvenate an aged or damaged bone marrow hematopoietic niche.
Review
Biochemistry & Molecular Biology
Izabella Skulimowska, Justyna Sosniak, Monika Gonka, Agata Szade, Alicja Jozkowicz, Krzysztof Szade
Summary: Recent studies on hematopoietic stem cells (HSCs) have shown promising opportunities and challenges for their clinical applications. The heterogenic pool of HSCs dynamically changes with aging, involving complex interactions with the bone marrow niche. These findings may lead to overcoming current limitations in HSC transplantation and expanding the patient group that can benefit from the clinical potential of HSCs.
Article
Cell & Tissue Engineering
Novella Guidi, Gina Marka, Vadim Sakk, Yi Zheng, Maria Carolina Florian, Hartmut Geiger
Summary: The study found that an aged niche restrains the function of ex vivo rejuvenated old HSCs, with a low level of the cytokine osteopontin being a contributing factor. Sustainable rejuvenation of the function of aged HSCs in vivo will need to address the influence of an aged niche on rejuvenated HSCs.
Review
Biochemistry & Molecular Biology
Muhammad Faisal, Mubashir Hassan, Aman Kumar, Muhammad Zubair, Muhammad Jamal, Harish Menghwar, Muhammad Saad, Andrzej Kloczkowski
Summary: This review provides an update on the functional roles of different genetic and epigenetic factors and molecular signaling events in different sections of the hematopoietic microenvironment. The explorations of different molecular approaches and interventions using the latest web-based tools are outlined. This will help us gain more mechanistic insights and develop therapeutic options for malignancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Runfeng Miao, Harim Chun, Xing Feng, Ana Cordeiro Gomes, Jungmin Choi, Joao P. Pereira
Summary: This study reveals that a complex homeostatic balance between hematopoietic stem cells (HSCs) and hematopoietic progenitor cells is maintained through competition for a limited amount of cell signaling molecule. When early hematopoietic progenitors fail to interact with specific cells, HSC numbers increase.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Laura Mosteo, Joanna Storer, Kiran Batta, Emma J. Searle, Delfim Duarte, Daniel H. Wiseman
Summary: This review provides an overview of the bone marrow microenvironment, focusing on refined analyses of the marrow vascular compartment in mouse studies. It discusses the emerging role of the vascular niche in inflamm-aging, clonal hematopoiesis, and how the endothelial microenvironment influences malignant myelopoiesis. Strategies for modulating these bidirectional interactions for therapeutic effect in myeloid malignancies are also outlined.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Yan Man, Xiangmei Yao, Tonghua Yang, Yajie Wang
Summary: The self-renewal and differentiation of hematopoietic stem cells are tightly controlled by various cells and cytokines in the bone marrow microenvironment. Changes in the niche composition can lead to hematological malignancies, and processes like homing, proliferation, and differentiation of HSCs are crucial for the success of hematopoietic stem cell transplantation. Single-cell sequencing and in vivo imaging are powerful tools for studying the bone marrow microenvironment in diseases like leukemia and after transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Stefania Crippa, Ludovica Santi, Margherita Berti, Giada De Ponti, Maria Ester Bernardo
Summary: The human organism requires the production of approximately 1 trillion new blood cells per day through hematopoiesis in the bone marrow, regulated by the BM microenvironment and HSPCs. The BM niche, defined by interactions between HSPCs and non-hematopoietic cells, controls HSPC maintenance and orchestrates hematopoiesis according to the body's needs. Mesenchymal stromal cells (MSCs) play a key role in the BM niche by regulating HSPC homeostasis and impacting the outcome of hematopoietic stem cell transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dermatology
Norifumi Urao, Jinghua Liu, Kentaro Takahashi, Gayathri Ganesh
Summary: The status of hematopoietic stem cells (HSCs) is crucial for wound healing responses, with recent advances shedding light on the role of myeloid cells and the importance of understanding HSC functions. Future research on HSCs producing blood cells could lead to the development of blood biomarkers predicting chronic wounds, revolutionizing wound care with precision medicine for high-risk patients.
ADVANCES IN WOUND CARE
(2022)
Review
Pharmacology & Pharmacy
Cornelia Lee-Thedieck, Peter Schertl, Gerd Klein
Summary: This review provides a comprehensive overview of the extracellular matrix (ECM) in hematopoietic stem cell (HSC) niches and highlights its importance in regulating cellular function and niche structure. The role of different classes of ECM molecules and their interactions with cells are discussed, along with the significance of matrix remodeling and biophysics in HSC niche function. The review also examines the application of current knowledge of ECM in artificial HSC niches for HSC expansion, targeted differentiation, and drug testing.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Biotechnology & Applied Microbiology
Michela Bruschi, Tania Vanzolini, Neety Sahu, Alessandra Balduini, Mauro Magnani, Alessandra Fraternale
Summary: This review focuses on the functionalization of 3D scaffolds for hematopoietic stem cells (HSCs), aiming to promote their growth and differentiation. Special attention is given to 3D systems for recreating megakaryocyte products for blood cell production.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
