Article
Multidisciplinary Sciences
Oleg Palygin, Christine A. Klemens, Elena Isaeva, Vladislav Levchenko, Denisha R. Spires, Lashodya Dissanayake, Oksana Nikolaienko, Daria Ilatovskaya, Alexander Staruschenko
Summary: The study found that renal purinergic signaling undergoes significant remodeling in diabetes, leading to an increase in ATP-mediated intracellular calcium flux in podocytes. P2X4 and P2X7 were identified as the major receptors contributing to the augmented ATP-mediated intracellular calcium signaling in diabetic podocytes.
Article
Biochemistry & Molecular Biology
Lina Xing, Hengjiang Guo, Sixuan Meng, Bingbing Zhu, Ji Fang, Jiebo Huang, Junliang Chen, Yunman Wang, Li Wang, Xingmei Yao, Hao Wang
Summary: Klotho activates the Nrf2 signaling pathway to inhibit oxidative stress and apoptosis induced by high glucose, thus protecting podocytes. This protective effect may be targeted by activating Nrf2 for the treatment of diabetic nephropathy (DN).
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Tomasz Kulesza, Marlena Typiak, Patrycja Rachubik, Dorota Rogacka, Irena Audzeyenka, Moin A. Saleem, Agnieszka Piwkowska
Summary: Podocytes play a crucial role in blood filtration, and their proper function depends on efficient insulin responsiveness. Insulin resistance of podocytes, characterized by a reduced sensitivity to insulin, is the earliest mechanism leading to microalbuminuria in metabolic syndrome and diabetic nephropathy. This resistance is mediated by NPP1, an enzyme involved in phosphate homeostasis regulation, which inhibits downstream cellular signaling by binding to the insulin receptor. Hyperglycemic conditions also affect Pit 1, a protein involved in phosphate balance, and our study found an interaction between NPP1 and Pit 1 after stimulation with insulin. Downregulation of the SLC20A1 gene, encoding Pit 1, resulted in insulin resistance in podocytes, indicating that Pit 1 may be a key factor in NPP1-mediated insulin signaling inhibition.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Genetics & Heredity
Irena Audzeyenka, Patrycja Rachubik, Marlena Typiak, Tomasz Kulesza, Daria Kalkowska, Dorota Rogacka, Michal Rychlowski, Stefan Angielski, Moin Saleem, Agnieszka Piwkowska
Summary: In this study, the role of PINK1 in insulin signaling and the maintenance of proper permeability in podocytes was investigated. PINK1 deficiency was found to increase albumin permeability and impair glucose uptake in podocytes. Additionally, PINK1 depletion led to lower expression of podocin and nephrin in podocytes.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Pharmacology & Pharmacy
Erina Sugita, Kaori Hayashi, Akihito Hishikawa, Hiroshi Itoh
Summary: Epigenetic alterations in podocytes are associated with chronic kidney disease, including diabetic nephropathy. Detection of these changes may serve as a promising strategy for estimating kidney damage and prognosis. Targeting epigenetic podocyte changes and associated DNA damage could be a novel therapeutic approach for preventing progression to end-stage renal disease in diabetic nephropathy patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marina Rousseau, Benoit Denhez, Crysta Spino, Farah Lizotte, Andreanne Guay, Anne-Marie Cote, Dylan Burger, Pedro Geraldes
Summary: The reduction of DUSP4 in diabetes leads to JNK activation and increased expression of Nox4, resulting in podocyte dysfunction, insulin resistance, and progression of diabetic nephropathy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Nutrition & Dietetics
Ran Nakamichi, Kaori Hayashi, Hiroshi Itoh
Summary: Podocytes are highly differentiated cells that cover the outside of glomerular capillaries, and damage to podocytes leads to proteinuria and glomerulosclerosis. Diabetes is a main cause of CKD, making it crucial to understand its effects on podocytes for preventing CKD progression.
Article
Pharmacology & Pharmacy
Ruixue Guo, Peipei Wang, Xuejun Zheng, Wen Cui, Jin Shang, Zhanzheng Zhao
Summary: This study demonstrates that the SGLT2 inhibitor dapagliflozin protects podocytes from diabetic nephropathy by regulating the IGF1R/PI3K signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dorota Rogacka
Summary: This review summarizes cellular and molecular alterations that contribute to the development of insulin resistance in glomerular podocytes.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Tian-tian Wei, Le-tian Yang, Fan Guo, Si-bei Tao, Lu Cheng, Rong-shuang Huang, Liang Ma, Ping Fu
Summary: Activation of GPR120 in podocytes plays a crucial role in ameliorating renal inflammation and fibrosis to protect against DN.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Endocrinology & Metabolism
Jing Chang, Jinsu Zheng, Xia Gao, Hengbei Dong, Haitian Yu, Mengxiu Huang, Zhencheng Sun, Xiaomeng Feng
Summary: This study indicates that TSWN alleviates diabetic nephropathy (DN) by improving podocyte injury through the SIRT1/HIF-1 alpha pathway in diabetic mouse kidneys.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xue Li, Lihong Lu, Wenting Hou, Ting Huang, Xiangyuan Chen, Jie Qi, Yanjun Zhao, Minmin Zhu
Summary: This review discusses the important role of epigenetics in diabetic nephropathy, which affects the progression of the disease through various mechanisms and ultimately leads to a poor prognosis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Medicine, Research & Experimental
Aili Cao, Jianhua Li, Morad Asadi, John M. Basgen, Bingbing Zhu, Zhengzi Yi, Song Jiang, Tomohito Doke, Osama El Shamy, Niralee Patel, Paolo Cravedi, Evren U. Azeloglu, Kirk N. Campbell, Madhav Menon, Steve Coca, Weijia Zhang, Hao Wang, Ke Zen, Zhihong Liu, Barbara Murphy, John C. He, Vivette D. D'Agati, Katalin Susztak, Lewis Kaufman
Summary: DACH1 is a key gene in DKD that, when underexpressed, increases podocyte vulnerability to injury.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Plant Sciences
Xuansheng Ding, Hanzhen Zhao, Chen Qiao
Summary: This study found that ICA can inhibit the activation of NLRP3 inflammasome by increasing Sesn2-induced mitophagy, thus exerting a protective effect.
Article
Multidisciplinary Sciences
Wael Osman, Mira Mousa, Mohammed Albreiki, Zahrah Baalfaqih, Hinda Daggag, Claire Hill, Amy Jayne McKnight, Alexander P. Maxwell, Habiba Al Safar
Summary: Diabetic kidney disease (DKD), or diabetic nephropathy, is a major cause of renal impairment and end-stage renal disease. This study conducted a genome-wide association study to investigate genetic factors associated with the development and progression of DKD in the Emirati population. The CNR2 gene was found to be significantly associated with the development of DKD in individuals with type 2 diabetes mellitus (T2DM).
SCIENTIFIC REPORTS
(2023)
