Article
Biochemistry & Molecular Biology
Suisui Wang, Jingxiu Bi, Chengjun Li, Bin Li
Summary: This study reveals that the GBL domain of TcLph can recognize pathogens and trigger immune defense responses. The GBL domain is highly conserved and can bind to different types of molecules. Moreover, TcLph is significantly upregulated after infection and its silencing worsens bacterial infection and larval mortality. Therefore, TcLph may play an important role in insect defense against invasive microbes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Szilvia Lukacsi, Zsolt Farkas, Eva Saskoi, Zsuzsa Bajtay, Krisztina Takacs-Vellai
Summary: Endocytosis provides cellular nutrition and homeostasis, while pathogens often exploit this entry point to infect host cells. Phagocytosis plays a key role in protecting against invading microbes, with initial recognition of infection differing between mammals and C. elegans. However, molecules involved in efferocytosis are highly conserved between the two species, making C. elegans a powerful model for studying phagocytic mechanisms. Additionally, studies in both mammals and worms show that defective apoptotic cell clearance can lead to the activation of innate immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Nouhoum Dibo, Xianshu Liu, Yunfeng Chang, Shuaiqin Huang, Xiang Wu
Summary: Schistosomiasis is still a significant public health problem in tropical and subtropical regions, and its elimination remains challenging. Immune responses are crucial for controlling the disease, but prolonged inflammatory responses contribute to disease progression. Understanding the molecular mechanisms of innate immune responses is important for developing effective therapies and vaccines.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Jean-Yves Dube, Fiona McIntosh, Marcel A. Behr
Summary: Pattern recognition receptors Mincle and NOD2 are associated with mycobacterial immunity, but single gene knockout studies have shown mild phenotypes. Researchers hypothesized that dual knockout of Mincle and Nod2 would result in a more severe immune phenotype, but the results showed no further effect compared to Nod2 knockout alone.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anna E. Gauthier, Randi D. Rotjan, Jonathan C. Kagan
Summary: This review examines the history of LPS as a mammalian PAMP protein, recent data on LPS structure and its role in mammalian immune activation, and compares these activities across different eukaryotes. The authors discuss the reasons why LPS has immune-stimulatory effects in some organisms but not others, and propose two hypotheses about the evolution of PAMP structure.
Review
Immunology
Guang Han Ong, Benedict Shi Xiang Lian, Takumi Kawasaki, Taro Kawai
Summary: Adjuvants enhance vaccine potency by activating innate immune responses, which in turn stimulate acquired immune responses against pathogens. Current research focuses on the effectiveness of PAMPs and DAMPs as adjuvants, as well as gaining a comprehensive understanding of the immune reactions to agonists for PRRs.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Fisheries
Jhonatas Teixeira Viana, Rafael dos Santos Rocha, Rodrigo Maggioni
Summary: Lectins are important pattern recognition receptors in the immune system of L. vannamei, involved in multiple immune response pathways.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Zhi Zong, Zhengkui Zhang, Liming Wu, Long Zhang, Fangfang Zhou
Summary: Innate antiviral immunity is the first line of defense against viral pathogens, relying on pattern recognition receptors to recognize pathogen-associated molecular patterns and initiate signaling cascades producing proinflammatory cytokines and IFN-I. The ubiquitin system, specifically DUBs, plays crucial roles in regulating immune responses, with viral DUBs counteracting host immunity. The potential of utilizing DUBs as therapeutic targets for infectious diseases is discussed, along with the challenges.
Review
Immunology
Jin Kyung Seok, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee
Summary: Inflammation is a host protection mechanism that can eliminate invasive pathogens from the body, but chronic inflammation may lead to various inflammatory and autoimmune diseases. Recent studies have shown the significant contribution of the NLRP3 inflammasome to the pathology of various inflammatory diseases. Understanding the activation regulation of NLRP3 inflammasome by multiple signaling pathways, post-translational modifications, and cellular organelles is crucial for the development of therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Fisheries
Lage Cerenius, Kenneth Soderhall
Summary: Melanin production by different types of phenoloxidases provides immunity to a variety of pathogens, while proPO in arthropods exhibits multiple activities such as cytokine and microbiocidal activities. Pathogens influence proPO activation and the types of immune effects produced.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan Liu, Ao Zhang, Na Guo, Qiang Hao, Fuhua Li
Summary: In this study, a ficolin gene Ptficolin was characterized from the swimming crab Portunus trituberculatus. Ptficolin showed higher expression in stomach and hepatopancreas, and could recognize and eliminate invading pathogens, playing an important role in hemolymph coagulation in crabs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Oncology
Alice J. West, Virginie Deswaerte, Alison C. West, Linden J. Gearing, Patrick Tan, Brendan J. Jenkins
Summary: Results from studying the role of NLRP3 in gastric cancer suggest that NLRP3 does not play a major role in promoting inflammasome-driven gastric tumorigenesis. Additionally, cellular processes associated with tumorigenesis and inflammasome activation levels were similar between mice with and without NLRP3. Further investigations are needed to identify the key inflammasome-associated PRR implicated in GC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Karolina Sidor, Aldona Jeznach, Grazyna Hoser, Tomasz Skirecki
Summary: The NLRP3 inflammasome is a powerful intracellular sensor of danger and disturbances that can cause various inflammatory diseases. 1-MNA reduces the activation of the NLRP3 inflammasome and may be a potential therapeutic target for NLRP3-related disorders.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Kengo Nozaki, Lupeng Li, Edward A. Miao
Summary: Intracellular pathogens pose a significant threat to animals. Innate immune sensors detect these pathogens and trigger cell death responses, eliminating the infection and promoting immune responses. Pathogens evolve strategies to evade these sensors.
ANNUAL REVIEW OF IMMUNOLOGY
(2022)
Article
Immunology
Marie-Christine Bartens, Amanda J. Gibson, Graham J. Etherington, Federica Di Palma, Angela Holder, Dirk Werling, Sam Willcocks
Summary: Research suggests that there are differences in the response to mycobacterial antigens between Brown Swiss and Holstein Friesian cattle, potentially due to single nucleotide polymorphisms in the TLR2 gene.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Lynda Vuong, Eleni Kouverianou, Claire M. Rooney, Brian J. McHugh, Sarah E. M. Howie, Christopher D. Gregory, Stuart J. Forbes, Neil C. Henderson, Fredrik R. Zetterberg, Ulf J. Nilsson, Hakon Leffler, Paul Ford, Anders Pedersen, Lise Gravelle, Susan Tantawi, Hans Schambye, Tariq Sethi, Alison C. MacKinnon
Article
Biochemistry & Molecular Biology
Irundika H. K. Dias, Ivana Milic, Christian Heiss, Opeyemi S. Ademowo, Maria Cristina Polidori, Andrew Devitt, Helen R. Griffiths
ANTIOXIDANTS & REDOX SIGNALING
(2020)
Review
Biochemical Research Methods
Annaig J. Rozo, Megan H. Cox, Andrew Devitt, Alice J. Rothnie, Alan D. Goddard
Article
Biochemistry & Molecular Biology
Hoor Ayub, Michelle Clare, Ivana Milic, Nikola P. Chmel, Heike Boening, Andrew Devitt, Thomas Krey, Roslyn M. Bill, Alice J. Rothnie
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2020)
Article
Multidisciplinary Sciences
Chelsea N. Davis, Ana Winters, Ivana Milic, Andrew Devitt, Alan Cookson, Peter M. Brophy, Russell M. Morphew
SCIENTIFIC REPORTS
(2020)
Review
Biochemistry & Molecular Biology
Michael P. Rimmer, Christopher D. Gregory, Rod T. Mitchell
Summary: Research on extracellular vesicles (EVs) in male urogenital tract cancers has identified potential diagnostic and disease monitoring cargoes. EVs released by these cancers promote metastasis and evade immune responses, with potential to reduce the need for invasive biopsies by serving as diagnostic biomarkers.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Immunology
Ewan R. A. Ross, Andrew Devitt, Jill R. R. Johnson
Summary: Macrophages play critical roles in sterile inflammation and autoimmune diseases, particularly in the pathophysiology of diseases like rheumatoid arthritis. Imbalance in macrophage homeostasis contributes to chronic inflammation, and therapeutic strategies targeting macrophage plasticity are being explored. Apoptotic cell-derived extracellular vesicles may play a role in regulating macrophage phenotype and are a potential target for new therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ornella Morana, Will Wood, Christopher D. Gregory
Summary: Cancer growth is characterized by an imbalance between cell gain and cell loss, with high-grade cancers often having high levels of apoptosis. While cell-autonomous apoptosis serves as a tumor suppressor mechanism, limited apoptosis can promote cell survival and resistance to therapy by conditioning the tumor microenvironment. Understanding the implications of cell death programs in tumor biology is crucial for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Charlotte E. Clarke-Bland, Roslyn M. Bill, Andrew Devitt
Summary: Recent research has discovered the role of diverse AQPs in extracellular vesicles (EV). These AQPs have been suggested as biomarkers for disease, drug targets, and potential therapeutics. However, further understanding of AQPs in EV is needed as this field is still in its infancy.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2022)
Article
Multidisciplinary Sciences
Laura A. J. Feather, Vinod Nadella, Elisabeth Kastner, Yvonne Perrie, Anthony C. Hilton, Andrew Devitt
Summary: Liposomes are versatile systems in vaccine technology, acting as antigen delivery systems and adjuvants. This study develops an in vitro screening tool to predict the in vivo efficacy of novel liposome formulations.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Erica Cecilia Priori, Clara Alice Musi, Arianna Giani, Luca Colnaghi, Ivana Milic, Andrew Devitt, Tiziana Borsello, Mariaelena Repici
Summary: The activated JNK protein family can affect neuronal functions and survival. In Alzheimer's disease, the JNK cascade plays a role in synaptic impairment. By studying 5xFAD mice, it was found that JNK was activated early in the disease, leading to structural changes in the post-synaptic density and memory impairment. These findings suggest that JNK could be a key player in early neurodegeneration and a potential therapeutic target for Alzheimer's disease.
Meeting Abstract
Obstetrics & Gynecology
Michael Philip Rimmer, Christopher D. Gregory, Rod T. Mitchell
REPRODUCTIVE SCIENCES
(2022)
Review
Reproductive Biology
Michael P. Rimmer, Christopher D. Gregory, Rod T. Mitchell
Summary: Research has shown that EVs released from the male reproductive tract play a crucial role in the development and function of sperm by carrying RNA, protein, and lipid cargoes for post-testicular modification and development of sperm. While little is known about the interaction between EVs from the testes and the spermatogonial stem cell niche or developing sperm within the seminiferous tubules, these interactions are vital for the subsequent function of sperm.
REPRODUCTION AND FERTILITY
(2021)
Article
Pharmacology & Pharmacy
Rajagopal S. Kilari, Asma'u I. J. Bashir, Andreue Devitt, Christopher J. Perry, Stephen T. Safrany, Iain D. Nicholl
CURRENT CLINICAL PHARMACOLOGY
(2019)
Proceedings Paper
Optics
Andrea Usai, Neil Finlayson, Christopher D. Gregory, Colin J. Campbell, Robert K. Henderson
OPTICAL BIOPSY XVII: TOWARD REAL-TIME SPECTROSCOPIC IMAGING AND DIAGNOSIS
(2019)