Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2

Tumor Necrosis Factor (TNF) Signaling, but Not TWEAK (TNF-like Weak Inducer of Apoptosis)-triggered cIAP1 (Cellular Inhibitor of Apoptosis Protein 1) Degradation, Requires cIAP1 RING Dimerization and E2 Binding

(2010) Rebecca Feltham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asymmetric Recruitment of cIAPs by TRAF2

(2010) Peter D. Mace et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation

(2010) Chao Zheng et al.   MOLECULAR CELL

Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression

(2010) S. L. Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smac mimetics as new cancer therapeutics

(2009) Derrick J. Chen et al.   ANTI-CANCER DRUGS

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

(2009) Qian Yin et al.   BIOCHEMISTRY

RIPK1 is not essential for TNFR1-induced activation of NF-κB

(2009) W W-L Wong et al.   CELL DEATH AND DIFFERENTIATION

Human Caspases: Activation, Specificity, and Regulation

(2009) Cristina Pop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

(2009) James E. Vince et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Tangled Web of Ubiquitin Chains: Breaking News in TNF-R1 Signaling

(2009) Katiuscia Bianchi et al.   MOLECULAR CELL

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

(2008) Federica Cossu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP21

(2008) John W. Blankenship et al.   BIOCHEMICAL JOURNAL

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

TRAF2 and TRAF3 Signal Adapters Act Cooperatively to Control the Maturation and Survival Signals Delivered to B Cells by the BAFF Receptor

(2008) Sandra Gardam et al.   IMMUNITY

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

(2008) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment

(2008) Peter D. Mace et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis

(2008) Mads Gyrd-Hansen et al.   NATURE CELL BIOLOGY

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

(2008) Sivakumar Vallabhapurapu et al.   NATURE IMMUNOLOGY

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA