Article
Public, Environmental & Occupational Health
Ian R. White, Tra My Pham, Matteo Quartagno, Tim P. Morris
Summary: Simulation studies are important in epidemiology and biostatistics, but unexpected results can occur. To ensure quality, careful design and analysis with visual tools should be conducted to identify and address outliers and failed estimations.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Environmental Sciences
Manuel Conde-Cid, Manuel Arias-Estevez, Avelino Nunez-Delgado
Summary: Wastewater based epidemiology is considered a potential tool for early warning of COVID-19 outbreaks, but there is a lack of research on quantifying the virus in soil samples. Available data is being reviewed to explore methodological approaches for quantifying SARS-CoV-2 in soils.
ENVIRONMENTAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Ewa Dudzinska, Kinga Szymona, Renata Kloc, Tomasz Kocki, Paulina Gil-Kulik, Jacek Bogucki, Janusz Kocki, Roman Paduch, Ewa M. Urbanska
Summary: Fractalkine levels were significantly higher in AN patients, while sICAM-1, KYNA, KYN, TRP, and 3-OH-KYN levels were unchanged. The expression of KAT3 gene was increased in AN patients, but KAT1 and KAT2 genes showed no significant change. Fractalkine positively correlated with TRP, while sICAM-1 was negatively associated with 3-OH-KYN and positively linked with the ratio KYN/3-OH-KYN.
Review
Clinical Neurology
Philipp Mahlknecht, Thomas Foltynie, Patricia Limousin, Werner Poewe
Summary: A robust body of evidence has established the efficacy of deep brain stimulation (DBS) in reducing off time and dyskinesias in levodopa-treated patients with Parkinson's disease (PD). However, the long-term impact of DBS on the overall progression of disability in PD is less clear.
MOVEMENT DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Mingyang Qiu, Wenlong Wei, Jianqing Zhang, Hanze Wang, Yuxin Bai, De-an Guo
Summary: Flavonoids derived from citrus plants have been extensively studied by phytomedicinal researchers due to their diverse biological activities. This review provides a comprehensive summary of the scientometrics, chemical structures, and pharmacological action of citrus flavonoids. The focus is on their anticancer activities, neuroprotective effects, and metabolic diseases, along with the therapeutic mechanisms involved. It aims to serve as a valuable reference for researchers in the fields of anti-cancer and neuroprotective research.
Review
Geriatrics & Gerontology
Yi Zhang, Meng Zhang
Summary: Morinda officinalis How. (MO) is a traditional Chinese medicine with anti-inflammatory and antioxidant properties, making it effective in the treatment of Alzheimer's disease (AD) by suppressing inflammation and oxidative stress.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Yue Liu, Liuding Wang, Guang Yang, Xiansu Chi, Xiao Liang, Yunling Zhang
Summary: Stroke is a leading cause of death and disability worldwide, with the majority of cases being ischemic stroke. The review highlights the role of sirtuins (SIRTs), a group of enzymes involved in various biological processes, in ischemic stroke. The review discusses the distribution, subcellular location, enzyme activity, and regulatory roles of SIRTs in ischemic stroke, as well as potential therapeutic methods based on SIRTs. The data collected in this study has potential implications for clinical and fundamental research on SIRTs and the development of effective therapeutic candidates for ischemic stroke treatment.
Article
Biochemistry & Molecular Biology
Angela Genchi, Elena Brambilla, Francesca Sangalli, Marta Radaelli, Marco Bacigaluppi, Roberto Furlan, Annapaola Andolfo, Denise Drago, Cinzia Magagnotti, Giulia Maria Scotti, Raffaella Greco, Paolo Vezzulli, Linda Ottoboni, Marco Bonopane, Daniela Capilupo, Francesca Ruffini, Daniela Belotti, Benedetta Cabiati, Stefania Cesana, Giada Matera, Letizia Leocani, Vittorio Martinelli, Lucia Moiola, Luca Vago, Paola Panina-Bordignon, Andrea Falini, Fabio Ciceri, Anna Uglietti, Maria Pia Sormani, Giancarlo Comi, Mario Alberto Battaglia, Maria A. A. Rocca, Loredana Storelli, Elisabetta Pagani, Giuseppe Gaipa, Gianvito Martino
Summary: This study conducted a phase 1 clinical trial evaluating the feasibility, safety and tolerability of intrathecally transplanted human fetal neural precursor cells (hfNPCs) in patients with progressive multiple sclerosis (PMS). The results demonstrated that hfNPC therapy is feasible, safe and tolerable in PMS patients.
Review
Multidisciplinary Sciences
Sarmistha Mitra, Raju Dash, Amena Al Nishan, Sarmin Ummey Habiba, Il Soo Moon
Summary: This review examines the influence of the gut microbiota on neuronal development and neurodegenerative disorders, emphasizing the importance of understanding the balance between beneficial and harmful bacteria. It also highlights the potential therapeutic applications of targeting the gut microbiota population and its derivatives.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Catia R. Lopes, Vanessa S. Lourenco, Angelo R. Tome, Rodrigo A. Cunha, Paula M. Canas
Summary: The study explores the role of adenosine receptors in the brain, indicating the potential of A1R in neurodegeneration and A2AR in psychiatric conditions. Transgenic mouse experiments reveal the different roles of A2AR in various cell types and brain areas, emphasizing the regulatory role of adenosine in the brain and uncovering potential mechanisms of action.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Ecology
Sanja Maria Hakala, Haruna Fujioka, Katharina Gapp, Ornela De Gasperin, Eleonore Genzoni, Rebecca M. Kilner, Joris M. Koene, Barbara Konig, Timothy A. Linksvayer, Marie -Pierre Meurville, Matteo A. Negroni, Hugo Palejowski, Stuart Wigby, Adria C. LeBoeuf
Summary: When biological material is transferred from one individual's body to another, secondary donor-produced molecules are also transferred which can affect the physiology and fitness of the receiver. Both social and solitary animals exhibit such social transfers at certain life stages. The components of these socially transferred materials have evolved convergently and can drive the physiological and behavioral evolution of many taxa.
TRENDS IN ECOLOGY & EVOLUTION
(2023)
Editorial Material
Endocrinology & Metabolism
Di Wu, Jian Chen, Xuxiang Zhang, Roxanne Ilagan, Yuchuan Ding, Xunming Ji
Summary: Selective therapeutic cooling is a promising technique for reducing final infarct volume and improving outcomes in ischemic stroke. However, more targeted induction of brain hypothermia and mitigating potential side effects related to inducing hypothermia may be necessary to enhance the benefits of this method.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Yi-Fen Lai, Ting-Yi Lin, Yi-Hao Chen, Da-Wen Lu
Summary: Glaucoma, the second leading cause of blindness worldwide, can result in irreversible vision loss. The disease is complex, with various factors contributing to its development, such as ischemia, oxidative stress, neurotropic factor deprivation, and neuron excitotoxicity. Erythropoietin (EPO), a hormone that stimulates erythropoiesis in response to hypoxia, has been found to have neuroprotective effects and may be a potential treatment for rescuing retinal ganglion cells in glaucoma. This article explores the relationship between EPO and glaucoma and summarizes preclinical experiments using EPO, offering a different perspective on the incurability of glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Manuela Zinni, Julien Pansiot, Pierre-Louis Leger, Marina El Kamouh, Olivier Baud
Summary: Cerebral stroke, traumatic brain injury, and hypoxic ischemic encephalopathy are common brain injuries with a complex pathogenesis involving alterations of the cerebrovascular system, cell death, and inflammation. Preclinical data suggest that sildenafil may have a neuroprotective effect on both adult and neonatal brain injuries.
Article
Biochemistry & Molecular Biology
Edward Xie, Urooba Nadeem, Bingqing Xie, Mark D'Souza, Dinanath Sulakhe, Dimitra Skondra
Summary: Using a computational bioinformatics approach, we identified drug/chemical classes associated with retinal neuroprotection and found potential treatments such as anti-diabetics, lipid-lowering medicines, and antioxidants that could be repurposed for retinal neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)