Environmental signaling through the mechanistic target of rapamycin complex 1

Growth and aging: a common molecular mechanism

(2016) Mikhail V. Blagosklonny et al.   Aging-US

Where is mTOR and what is it doing there?

(2014) Charles Betz et al.   JOURNAL OF CELL BIOLOGY

A Nutrient-Responsive Pathway that Determines M Phase Timing through Control of B-Cyclin mRNA Stability

(2013) Vincent Messier et al.   CELL

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

(2013) Alfred Csibi et al.   CELL

The Regulation of Cell Size

(2013) Alison C. Lloyd   CELL

DNA Binding by the Ribosomal DNA Transcription Factor Rrn3 Is Essential for Ribosomal DNA Transcription

(2013) Ann Stepanchick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

Bromodomain inhibition halts heart failure

(2013) Alexandra Flemming   NATURE REVIEWS DRUG DISCOVERY

Regulation of nucleosome dynamics by histone modifications

(2013) Gabriel E Zentner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human

(2013) Benjamin Albert et al.   NUCLEIC ACIDS RESEARCH

Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae

(2013) L. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1

(2013) N. Panchaud et al.   Science Signaling

Target of rapamycin signaling regulates high mobility group protein association to chromatin, which functions to suppress necrotic cell death

(2013) Hongfeng Chen et al.   Epigenetics & Chromatin

Hypoxia, MTOR and autophagy

(2012) Mikhail V. Blagosklonny   Autophagy

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Rapamycin for life: A step to immortality

(2012) Zoya N. Demidenko   CELL CYCLE

Ser2481-autophosphorylated mTOR colocalizes with chromosomal passenger proteins during mammalian cell cytokinesis

(2012) Alejandro Vazquez-Martin et al.   CELL CYCLE

Ccr4-Not complex: the control freak of eukaryotic cells

(2012) Jason E. Miller et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Crystal Structure of the Gtr1pGTP-Gtr2pGDPProtein Complex Reveals Large Structural Rearrangements Triggered by GTP-to-GDP Conversion

(2012) Jae-Hee Jeong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The histone H3 lysine 56 acetylation pathway is regulated by target of rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis

(2012) Hongfeng Chen et al.   NUCLEIC ACIDS RESEARCH

Ego3 Functions as a Homodimer to Mediate the Interaction between Gtr1-Gtr2 and Ego1 in the EGO Complex to Activate TORC1

(2012) Tianlong Zhang et al.   STRUCTURE

Histone modifications and mitosis: countermarks, landmarks, and bookmarks

(2012) Fangwei Wang et al.   TRENDS IN CELL BIOLOGY

MAF1: a new target of mTORC1

(2011) Annemieke A. Michels   BIOCHEMICAL SOCIETY TRANSACTIONS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis

(2011) Yuehua Wei et al.   CELL CYCLE

mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes

(2011) Chi Kwan Tsang et al.   CELL CYCLE

Raptor, a positive regulatory subunit of mTOR complex 1, is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions (NORs)

(2011) Alejandro Vazquez-Martin et al.   CELL CYCLE

ATP-dependent chromatin remodeling: genetics, genomics and mechanisms

(2011) Diana C Hargreaves et al.   CELL RESEARCH

Proline-rich Akt substrate of 40kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway

(2011) Haitao Wang et al.   CELLULAR SIGNALLING

Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L

(2011) Alexandre Huber et al.   EMBO JOURNAL

Expression of yeast high mobility group protein HMO1 is regulated by TOR signaling

(2011) LiJuan Xiao et al.   GENE

Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation

(2011) R. Gong et al.   GENES & DEVELOPMENT

Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth

(2011) C. Blattner et al.   GENES & DEVELOPMENT

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

(2011) Robbie Loewith et al.   GENETICS

The Histone Chaperone FACT: Structural Insights and Mechanisms for Nucleosome Reorganization

(2011) Duane D. Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

(2011) Ling Cai et al.   MOLECULAR CELL

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

mTOR signaling regulates the processing of pre-rRNA in human cells

(2011) Valentina Iadevaia et al.   NUCLEIC ACIDS RESEARCH

Multiple TORC1-Associated Proteins Regulate Nitrogen Starvation-Dependent Cellular Differentiation in Saccharomyces cerevisiae

(2011) Sunil Laxman et al.   PLoS One

Temperature-sensitive ipl1-2/Aurora B mutation is suppressed by mutations in TOR complex 1 via the Glc7/PP1 phosphatase

(2011) K. Tatchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Molecular Basis of RNA Polymerase III Transcription Repression by Maf1

(2010) Alessandro Vannini et al.   CELL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Growth stimulation leads to cellular senescence when the cell cycle is blocked

(2010) Zoya N. Demidenko et al.   CELL CYCLE

Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae

(2010) Bart Smets et al.   CURRENT GENETICS

The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin

(2010) Elaine Sanij et al.   Epigenetics

Reduction in Ribosomal Protein Synthesis Is Sufficient To Explain Major Effects on Ribosome Production after Short-Term TOR Inactivation in Saccharomyces cerevisiae

(2010) A. Reiter et al.   MOLECULAR AND CELLULAR BIOLOGY

mTORC1 Directly Phosphorylates and Regulates Human MAF1

(2010) A. A. Michels et al.   MOLECULAR AND CELLULAR BIOLOGY

Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae

(2010) Cheol Woong Ha et al.   NUCLEIC ACIDS RESEARCH

TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA production

(2010) Anja Philippi et al.   NUCLEIC ACIDS RESEARCH

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

(2010) Hiyaa Singhee Ghosh et al.   PLoS One

Raptor is Phosphorylated by cdc2 during Mitosis

(2010) Dana M. Gwinn et al.   PLoS One

mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1

(2010) T. Kantidakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

(2010) R. J. O. Dowling et al.   SCIENCE

The histone shuffle: histone chaperones in an energetic dance

(2010) Chandrima Das et al.   TRENDS IN BIOCHEMICAL SCIENCES

Insulin-like growth factor-I receptor signal transduction and the Janus Kinase/Signal Transducer and Activator of Transcription (JAK-STAT) pathway

(2009) Eddy Himpe et al.   BIOFACTORS

CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells

(2009) R.-q. Chen et al.   CANCER RESEARCH

Common mechanisms of PIKK regulation

(2009) Courtney A. Lovejoy et al.   DNA REPAIR

The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK–ERK pathway to late endosomes

(2009) Shigeyki Nada et al.   EMBO JOURNAL

Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1

(2009) Yuehua Wei et al.   EMBO JOURNAL

Calorie restriction and the exercise of chromatin

(2009) A. Vaquero et al.   GENES & DEVELOPMENT

Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis

(2009) A. Huber et al.   GENES & DEVELOPMENT

Regulation of RNA Polymerase III Transcription InvolvesSCH9-dependent andSCH9-independent Branches of the Target of Rapamycin (TOR) Pathway

(2009) JaeHoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Vam6 GEF Controls TORC1 by Activating the EGO Complex

(2009) Matteo Binda et al.   MOLECULAR CELL

Sfp1 Interaction with TORC1 and Mrs6 Reveals Feedback Regulation on TOR Signaling

(2009) Harri Lempiäinen et al.   MOLECULAR CELL

AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply

(2009) S. Hoppe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TOR complex 2: a signaling pathway of its own

(2009) Nadine Cybulski et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nutrient control of TORC1, a cell-cycle regulator

(2009) Xuemin Wang et al.   TRENDS IN CELL BIOLOGY

Genetic evidence that Ras-like GTPases, Gtr1p, and Gtr2p, are involved in epigenetic control of gene expression in Saccharomyces cerevisiae

(2008) Takeshi Sekiguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetic Control of rDNA Loci in Response to Intracellular Energy Status

(2008) Akiko Murayama et al.   CELL

cdc2–cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner

(2008) Ewan M Smith et al.   EMBO JOURNAL

TOR1 and TOR2 Have Distinct Locations in Live Cells

(2008) Thomas W. Sturgill et al.   EUKARYOTIC CELL

Actively transcribed rRNA genes in S. cerevisiae are organized in a specialized chromatin associated with the high-mobility group protein Hmo1 and are largely devoid of histone molecules

(2008) K. Merz et al.   GENES & DEVELOPMENT

UBF levels determine the number of active ribosomal RNA genes in mammals

(2008) Elaine Sanij et al.   JOURNAL OF CELL BIOLOGY

Arsenic Toxicity to Saccharomyces cerevisiae Is a Consequence of Inhibition of the TORC1 Kinase Combined with a Chronic Stress Response

(2008) Dagmar Hosiner et al.   MOLECULAR BIOLOGY OF THE CELL

The Yeast Tor Signaling Pathway Is Involved in G2/M Transition via Polo-Kinase

(2008) Akio Nakashima et al.   PLoS One

Obesity and cancer

(2008) Tobias Pischon et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

The INO80 chromatin remodeling complex in transcription, replication and repair

(2008) Ronald C. Conaway et al.   TRENDS IN BIOCHEMICAL SCIENCES