Ser2481-autophosphorylated mTOR colocalizes with chromosomal passenger proteins during mammalian cell cytokinesis

Validation of anti-aging drugs by treating age-related diseases

(2016) Mikhail V. Blagosklonny   Aging-US

Molecular damage in cancer: an argument for mTOR-driven aging

(2016) Mikhail V. Blagosklonny   Aging-US

Gerosuppressant Metformin: less is more

(2016) Javier A. Menendez et al.   Aging-US

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging

(2016) Mikhail V. Blagosklonny   Aging-US

A mitosis-specific AMPK trimer?

(2012) Mar Carmena   CELL CYCLE

Polo-like kinase 1 directs the AMPK-mediated activation of myosin regulatory light chain at the cytokinetic cleavage furrow independently of energy balance

(2012) Alejandro Vazquez-Martin et al.   CELL CYCLE

AMPK: A bona fide resident of the mitotic spindle midzone

(2012) Javier A. Menendez et al.   CELL CYCLE

Subunit composition of AMPK trimers present in the cytokinetic apparatus: Implications for drug target identification

(2012) Katalin Pinter et al.   CELL CYCLE

AMPK Regulates Mitotic Spindle Orientation through Phosphorylation of Myosin Regulatory Light Chain

(2012) J. T. Thaiparambil et al.   MOLECULAR AND CELLULAR BIOLOGY

Ramping Up Mitosis: An AMPKα2-Regulated Signaling Network Promotes Mitotic Progression

(2012) Aaron M. Robitaille et al.   MOLECULAR CELL

TOR-driven aging: Speeding car without brakes

(2011) Mikhail V Blagosklonny   CELL CYCLE

Aging-suppressants: Cellular senescence (hyperactivation) and its pharmacologic deceleration

(2011) Mikhail V Blagosklonny   CELL CYCLE

The active form of the metabolic sensor AMP-activated protein kinase α (AMPKα) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis

(2011) Alejandro Vazquez-Martin et al.   CELL CYCLE

Mitotic kinase dynamics of the active form of AMPK (Phospho-AMPKαThr172) in human cancer cells

(2011) Alejandro Vazquez-Martin et al.   CELL CYCLE

Raptor, a positive regulatory subunit of mTOR complex 1, is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions (NORs)

(2011) Alejandro Vazquez-Martin et al.   CELL CYCLE

mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: A roadmap from energy metabolism to stem cell renewal and aging

(2011) Javier A. Menendez et al.   CELL CYCLE

Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus

(2011) Alejandro Vazquez-Martin et al.   CELL CYCLE

Mitotic lymphoma cells are characterized by high expression of phosphorylated ribosomal S6 protein

(2011) Gábor Egervári et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

(2011) Max R. Banko et al.   MOLECULAR CELL

mTOR Controls Ovarian Follicle Growth by Regulating Granulosa Cell Proliferation

(2011) James Yu et al.   PLoS One

Prevention of cancer by inhibiting aging

(2010) Mikhail V Blagosklonny   CANCER BIOLOGY & THERAPY

Regulation of Insulin-like Growth Factor–Mammalian Target of Rapamycin Signaling by MicroRNA in Childhood Adrenocortical Tumors

(2010) Mabrouka Doghman et al.   CANCER RESEARCH

AMPK: Evidence for an energy-sensing cytokinetic tumor suppressor

(2010) Alejandro Vazquez-Martin et al.   CELL CYCLE

Rapamycin and quasi-programmed aging: Four years later

(2010) Mikhail V Blagosklonny   CELL CYCLE

Mitotic Raptor Promotes mTORC1 Activity, G2/M Cell Cycle Progression, and Internal Ribosome Entry Site-Mediated mRNA Translation

(2010) F. Ramirez-Valle et al.   MOLECULAR AND CELLULAR BIOLOGY

Raptor is Phosphorylated by cdc2 during Mitosis

(2010) Dana M. Gwinn et al.   PLoS One

The serine 2481-autophosphorylated form of mammalian Target Of Rapamycin (mTOR) is localized to midzone and midbody in dividing cancer cells

(2009) Alejandro Vazquez-Martin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2

(2009) J. Copp et al.   CANCER RESEARCH

mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action

(2009) Ghada A. Soliman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity

(2008) João Pedro de Magalhães et al.   BIOESSAYS

A Putative Mitotic Checkpoint Dependent on mTOR Function Controls Cell Proliferation and Survival in Ovarian Granulosa Cells

(2008) Aylin Yaba et al.   Reproductive Sciences

mTOR—What Does It Do?

(2008) M.N. Hall   TRANSPLANTATION PROCEEDINGS