E3 ubiquitin ligase Cbl-b in innate and adaptive immunity

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

(2014) Magdalena Paolino et al.   NATURE

E3 Ubiquitin Ligase Cbl-b Suppresses Proallergic T Cell Development and Allergic Airway Inflammation

(2014) Guilin Qiao et al.   Cell Reports

T Cell Activation Threshold Regulated by E3 Ubiquitin Ligase Cbl-b Determines Fate of Inducible Regulatory T Cells

(2013) G. Qiao et al.   JOURNAL OF IMMUNOLOGY

Protein tyrosine kinase regulation by ubiquitination: Critical roles of Cbl-family ubiquitin ligases

(2012) Bhopal Mohapatra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Whole-exome sequencing of a pedigree segregating asthma

(2012) Andrew T DeWan et al.   BMC Medical Genetics

IL-17-deficient allogeneic bone marrow transplantation prevents the induction of collagen-induced arthritis in DBA/1J mice

(2012) Min-Jung Park et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Ubiquitylation-Dependent Negative Regulation of WASp Is Essential for Actin Cytoskeleton Dynamics

(2012) B. Reicher et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

(2012) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Adoptive Transfer of siRNA Cblb-Silenced CD8+ T Lymphocytes Augments Tumor Vaccine Efficacy in a B16 Melanoma Model

(2012) Reinhard Hinterleitner et al.   PLoS One

E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity

(2012) Hui Guo et al.   Cell Reports

Reinforcement of cancer immunotherapy by adoptive transfer of cblb -deficient CD8+ T cells combined with a DC vaccine

(2011) Christina Lutz-Nicoladoni et al.   IMMUNOLOGY AND CELL BIOLOGY

c-Cbl and Cbl-b Ligases Mediate 17-Allylaminodemethoxygeldanamycin-induced Degradation of Autophosphorylated Flt3 Kinase with Internal Tandem Duplication through the Ubiquitin Proteasome Pathway

(2011) Gaku Oshikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential Role of E3 Ubiquitin Ligase Activity in Cbl-b-Regulated T Cell Functions

(2011) M. Paolino et al.   JOURNAL OF IMMUNOLOGY

Visualizing the Role of Cbl-b in Control of Islet-Reactive CD4 T Cells and Susceptibility to Type 1 Diabetes

(2011) G. F. Hoyne et al.   JOURNAL OF IMMUNOLOGY

Expression and function of Cbl-b in T cells from patients with systemic lupus erythematosus, and detection of the 2126 A/G Cblb gene polymorphism in the Mexican mestizo population

(2011) L Doníz-Padilla et al.   LUPUS

CIN85 Interacting Proteins in B Cells-Specific Role for SHIP-1

(2011) Tom Büchse et al.   MOLECULAR & CELLULAR PROTEOMICS

Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction

(2011) I. K. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b

(2011) Y. Kobashigawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RINGs hold the key to ubiquitin transfer

(2011) Rhesa Budhidarmo et al.   TRENDS IN BIOCHEMICAL SCIENCES

Myeloid Leukemia Development in c-Cbl RING Finger Mutant Mice Is Dependent on FLT3 Signaling

(2010) Chozhavendan Rathinam et al.   CANCER CELL

Syk mediates BCR- and CD40-signaling integration during B cell activation

(2010) Haiyan Ying et al.   IMMUNOBIOLOGY

The N Terminus of Cbl-c Regulates Ubiquitin Ligase Activity by Modulating Affinity for the Ubiquitin-conjugating Enzyme

(2010) Philip E. Ryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abrogating Cbl-b in effector CD8+ T cells improves the efficacy of adoptive therapy of leukemia in mice

(2010) Ingunn M. Stromnes et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells

(2010) Yohsuke Harada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis

(2010) Serena Sanna et al.   NATURE GENETICS

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency

(2010) C. E. Teh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Src-family and Syk Kinases in Activating and Inhibitory Pathways in Innate Immune Cells: Signaling Cross Talk

(2010) C. A. Lowell   Cold Spring Harbor Perspectives in Biology

The Role of Ubiquitin in NF-κB Regulatory Pathways

(2009) Brian Skaug et al.   Annual Review of Biochemistry

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

An Extensive Survey of Tyrosine Phosphorylation Revealing New Sites in Human Mammary Epithelial Cells

(2009) Tyler H. Heibeck et al.   JOURNAL OF PROTEOME RESEARCH

Ubiquitylation in innate and adaptive immunity

(2009) Vijay G. Bhoj et al.   NATURE

The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

(2009) Chen Wang et al.   NATURE IMMUNOLOGY

Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1

(2009) S. Kojo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PKC-  Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation

(2009) T. Gruber et al.   Science Signaling

Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins

(2008) E. Y. Choi et al.   BLOOD

Regulation of the stability and transcriptional activity of NFATc4 by ubiquitination

(2008) Yongna Fan et al.   FEBS LETTERS

T-Cell Receptor-Induced NF- B Activation Is Negatively Regulated by E3 Ubiquitin Ligase Cbl-b

(2008) G. Qiao et al.   MOLECULAR AND CELLULAR BIOLOGY

Kinase-Selective Enrichment Enables Quantitative Phosphoproteomics of the Kinome across the Cell Cycle

(2008) Henrik Daub et al.   MOLECULAR CELL

Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells

(2008) Baoli Yang et al.   NATURE IMMUNOLOGY

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential ubiquitin binding of the UBA domains from human c-Cbl and Cbl-b: NMR structural and biochemical insights

(2008) Zi-Ren Zhou et al.   PROTEIN SCIENCE