Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan

Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density

(2016) Yong Pan et al.   Aging-US

The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1

(2016) Gino Heeren et al.   Aging-US

Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential

(2016) Zoya N. Demidenko et al.   Aging-US

Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level

(2016) Alexander A. Goldberg et al.   Aging-US

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes

(2016) Alexander A. Goldberg et al.   Aging-US

Polyamines in aging and disease

(2016) Nadège Minois et al.   Aging-US

Answering the ultimate question “What is the Proximal Cause of Aging?”

(2016) Mikhail V. Blagosklonny   Aging-US

Big mice die young but large animals live longer

(2016) Mikhail V. Blagosklonny   Aging-US

Mitochondrial membrane lipidome defines yeast longevity

(2016) Adam Beach et al.   Aging-US

Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis

(2016) Vincent R. Richard et al.   Aging-US

Cells with Impaired Mitochondrial H2O2 Sensing Generate Less •OH Radicals and Live Longer

(2014) Dorival Martins et al.   ANTIOXIDANTS & REDOX SIGNALING

A lifespan-extending form of autophagy employs the vacuole-vacuole fusion machinery

(2014) Fusheng Tang et al.   Autophagy

Links between nucleolar activity, rDNA stability, aneuploidy and chronological aging in the yeast Saccharomyces cerevisiae

(2014) Anna Lewinska et al.   BIOGERONTOLOGY

Global changes in gene expression associated with phenotypic switching of wild yeast

(2014) Vratislav Šťovíček et al.   BMC GENOMICS

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

(2014) Rafael de Cabo et al.   CELL

The mystery of aging and rejuvenation—a budding topic

(2014) Thomas Nyström et al.   CURRENT OPINION IN MICROBIOLOGY

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Lifespan Extension Conferred by Endoplasmic Reticulum Secretory Pathway Deficiency Requires Induction of the Unfolded Protein Response

(2014) Vyacheslav M. Labunskyy et al.   PLoS Genetics

A sphingolipid-dependent diffusion barrier confines ER stress to the yeast mother cell

(2014) Lori Clay et al.   eLife

The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies

(2013) Sandra Paiva et al.   BIOCHEMICAL JOURNAL

Aging is not programmed

(2013) Mikhail V Blagosklonny   CELL CYCLE

MTOR-driven quasi-programmed aging as a disposable soma theory: Blind watchmaker vs. intelligent designer

(2013) Mikhail V Blagosklonny   CELL CYCLE

Macromitophagy, neutral lipids synthesis, and peroxisomal fatty acid oxidation protect yeast from “liponecrosis”, a previously unknown form of programmed cell death

(2013) Sara Sheibani et al.   CELL CYCLE

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

(2013) Elizabeth A. Schroeder et al.   Cell Metabolism

Actin Dynamics Affect Mitochondrial Quality Control and Aging in Budding Yeast

(2013) Ryo Higuchi et al.   CURRENT BIOLOGY

End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging

(2013) Joe R. Delaney et al.   FEMS YEAST RESEARCH

Aging and differentiation in yeast populations: elders with different properties and functions

(2013) Zdena Palková et al.   FEMS YEAST RESEARCH

Protein quality control in time and space - links to cellular aging

(2013) Thomas Nyström et al.   FEMS YEAST RESEARCH

A network of interorganellar communications underlies cellular aging

(2013) Anna Leonov et al.   IUBMB LIFE

Why translation counts for mitochondria - retrograde signalling links mitochondrial protein synthesis to mitochondrial biogenesis and cell proliferation

(2013) B. J. Battersby et al.   JOURNAL OF CELL SCIENCE

Key events during the transition from rapid growth to quiescence in budding yeast require posttranscriptional regulators

(2013) Lihong Li et al.   MOLECULAR BIOLOGY OF THE CELL

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Rapidly Developing Yeast Microcolonies Differentiate in a Similar Way to Aging Giant Colonies

(2013) Libuše Váchová et al.   Oxidative Medicine and Cellular Longevity

Roles of Mitochondrial Dynamics under Stressful and Normal Conditions in Yeast Cells

(2013) Dmitry A. Knorre et al.   Oxidative Medicine and Cellular Longevity

Calorie Restriction Hysteretically Primes Aging Saccharomyces cerevisiae toward More Effective Oxidative Metabolism

(2013) Erich B. Tahara et al.   PLoS One

Inheritance of the fittest mitochondria in yeast

(2013) Jason D. Vevea et al.   TRENDS IN CELL BIOLOGY

Aging Yeast Cells Undergo a Sharp Entry into Senescence Unrelated to the Loss of Mitochondrial Membrane Potential

(2013) Steffen Fehrmann et al.   Cell Reports

Xbp1 Directs Global Repression of Budding Yeast Transcription during the Transition to Quiescence and Is Important for the Longevity and Reversibility of the Quiescent State

(2013) Shawna Miles et al.   PLoS Genetics

Time line of redox events in aging postmitotic cells

(2013) Nicolas Brandes et al.   eLife

Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts

(2012) David Gems et al.   Annual Review of Physiology

Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?

(2012) David Gems et al.   ANTIOXIDANTS & REDOX SIGNALING

Aging and longevity of yeast colony populations: metabolic adaptation and differentiation

(2012) Libuše Váchová et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The retrograde response: When mitochondrial quality control is not enough

(2012) S. Michal Jazwinski   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan

(2012) Michelle T. Burstein et al.   CELL CYCLE

Acetic acid and acidification accelerate chronological and replicative aging in yeast

(2012) Mario G. Mirisola et al.   CELL CYCLE

Chronological and replicative lifespan in yeast

(2012) Michael Polymenis et al.   CELL CYCLE

pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast

(2012) Christopher Murakami et al.   CELL CYCLE

Mitochondrial Respiratory Thresholds Regulate Yeast Chronological Life Span and its Extension by Caloric Restriction

(2012) Alejandro Ocampo et al.   Cell Metabolism

Replicative and Chronological Aging in Saccharomyces cerevisiae

(2012) Valter D. Longo et al.   Cell Metabolism

Aging: One Thing Leads to Another

(2012) Marion Schmidt et al.   CURRENT BIOLOGY

Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae

(2012) Joe R. Delaney et al.   EXPERIMENTAL GERONTOLOGY

Hypertrophy, replicative ageing and the ageing process

(2012) Tomasz Bilinski   FEMS YEAST RESEARCH

A growing role for hypertrophy in senescence

(2012) Jill Wright et al.   FEMS YEAST RESEARCH

Tor1 regulates protein solubility in Saccharomyces cerevisiae

(2012) Theodore W. Peters et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

(2012) Liliana Malinovska et al.   MOLECULAR BIOLOGY OF THE CELL

Cell Differentiation within a Yeast Colony: Metabolic and Regulatory Parallels with a Tumor-Affected Organism

(2012) Michal Čáp et al.   MOLECULAR CELL

Identification of a complex genetic network underlyingSaccharomyces cerevisiaecolony morphology

(2012) Karin Voordeckers et al.   MOLECULAR MICROBIOLOGY

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

(2012) Adam L. Hughes et al.   NATURE

Reactive Oxygen Species in the Signaling and Adaptation of Multicellular Microbial Communities

(2012) Michal Čáp et al.   Oxidative Medicine and Cellular Longevity

Yeast Colonies: A Model for Studies of Aging, Environmental Adaptation, and Longevity

(2012) Libuše Váchová et al.   Oxidative Medicine and Cellular Longevity

Transcriptional Profiling of a Yeast Colony Provides New Insight into the Heterogeneity of Multicellular Fungal Communities

(2012) Ana Traven et al.   PLoS One

Confinement to Organelle-Associated Inclusion Structures Mediates Asymmetric Inheritance of Aggregated Protein in Budding Yeast

(2012) Rachel Spokoini et al.   Cell Reports

Integration of peroxisomes into an endomembrane system that governs cellular aging

(2012) Adam Beach et al.   Frontiers in Physiology

Caloric Restriction Extends Yeast Chronological Lifespan by Altering a Pattern of Age-Related Changes in Trehalose Concentration

(2012) Pavlo Kyryakov et al.   Frontiers in Physiology

Hypothesis: is yeast a clock model to study the onset of humans aging phenotypes?

(2012) Cristina Mazzoni et al.   Frontiers in Oncology

Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast

(2011) José Ricardo McFaline-Figueroa et al.   AGING CELL

Segregation of Protein Aggregates Involves Actin and the Polarity Machinery

(2011) Beidong Liu et al.   CELL

At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

In search of housekeeping pathways that regulate longevity

(2011) Adam Beach et al.   CELL CYCLE

Cell size and growth rate are major determinants of replicative lifespan

(2011) Jingye Yang et al.   CELL CYCLE

A genomic analysis of chronological longevity factors in budding yeast

(2011) Christopher R. Burtner et al.   CELL CYCLE

Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

(2011) Yong Pan et al.   Cell Metabolism

Interspecies Chemical Signals Released into the Environment may Create Xenohormetic, Hormetic and Cytostatic Selective Forces that Drive the Ecosystemic Evolution of Longevity Regulation Mechanisms

(2011) Michelle T. Burstein et al.   Dose-Response

Hypertrophy hypothesis as an alternative explanation of the phenomenon of replicative aging of yeast

(2011) Tomasz Biliński et al.   FEMS YEAST RESEARCH

Systems biology of yeast cell death

(2011) Ana Joyce Munoz et al.   FEMS YEAST RESEARCH

Yeast cells can access distinct quiescent states

(2011) M. M. Klosinska et al.   GENES & DEVELOPMENT

Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies

(2011) Libuše Váchová et al.   JOURNAL OF CELL BIOLOGY

Hsp42 is required for sequestration of protein aggregates into deposition sites inSaccharomyces cerevisiae

(2011) Sebastian Specht et al.   JOURNAL OF CELL BIOLOGY

Metabolic status rather than cell cycle signals control quiescence entry and exit

(2011) Damien Laporte et al.   JOURNAL OF CELL BIOLOGY

The proteomics of quiescent and nonquiescent cell differentiation in yeast stationary-phase cultures

(2011) George S. Davidson et al.   MOLECULAR BIOLOGY OF THE CELL

Absence of Mitochondrial Translation Control Proteins Extends Life Span by Activating Sirtuin-Dependent Silencing

(2011) Antonio Caballero et al.   MOLECULAR CELL

Composition and Acidification of the Culture Medium Influences Chronological Aging Similarly in Vineyard and Laboratory Yeast

(2011) Christopher J. Murakami et al.   PLoS One

Replicative Age Induces Mitotic Recombination in the Ribosomal RNA Gene Cluster of Saccharomyces cerevisiae

(2011) Derek L. Lindstrom et al.   PLoS Genetics

The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates

(2010) Beidong Liu et al.   CELL

Growth stimulation leads to cellular senescence when the cell cycle is blocked

(2010) Zoya N. Demidenko et al.   CELL CYCLE

Aging: ROS or TOR

(2010) Mikhail V Blagosklonny   CELL CYCLE

A role for ATM kinase activity and Mre11 in microhomology-mediated end-joining

(2010) Anthony J. Davis et al.   CELL CYCLE

Rapamycin and quasi-programmed aging: Four years later

(2010) Mikhail V Blagosklonny   CELL CYCLE

Apoptosis in yeast: triggers, pathways, subroutines

(2010) D Carmona-Gutierrez et al.   CELL DEATH AND DIFFERENTIATION

General factors important for the formation of structured biofilm-like yeast colonies

(2010) Vratislav Št’ovíček et al.   FUNGAL GENETICS AND BIOLOGY

Lessons on longevity from budding yeast

(2010) Matt Kaeberlein   NATURE

Molecular mechanisms of organelle inheritance: lessons from peroxisomes in yeast

(2010) Andrei Fagarasanu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity

(2010) A. Mesquita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Peroxisome Metabolism and Cellular Aging

(2010) Vladimir I. Titorenko et al.   TRAFFIC

A novel function of lipid droplets in regulating longevity

(2009) Alexander A. Goldberg et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Natural history of budding yeast

(2009) Duncan Greig et al.   CURRENT BIOLOGY

Effect of calorie restriction on the metabolic history of chronologically aging yeast

(2009) Alexander A. Goldberg et al.   EXPERIMENTAL GERONTOLOGY

Yeast Colony Survival Depends on Metabolic Adaptation and Cell Differentiation Rather Than on Stress Defense

(2009) Michal Čáp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myosin-driven peroxisome partitioning inS. cerevisiae

(2009) Andrei Fagarasanu et al.   JOURNAL OF CELL BIOLOGY

Budding Yeast SSD1-V Regulates Transcript Levels of Many Longevity Genes and Extends Chronological Life Span in Purified Quiescent Cells

(2009) Lihong Li et al.   MOLECULAR BIOLOGY OF THE CELL

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS

Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension

(2009) Min Wei et al.   PLoS Genetics

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells

(2009) Christopher Murakami et al.   Jove-Journal of Visualized Experiments

Measuring Replicative Life Span in the Budding Yeast

(2009) Kristan K. Steffen et al.   Jove-Journal of Visualized Experiments

Replicative Aging in Yeast: The Means to the End

(2008) K.A. Steinkraus et al.   Annual Review of Cell and Developmental Biology

Xenohormesis: Sensing the Chemical Cues of Other Species

(2008) Konrad T. Howitz et al.   CELL

A mother’s sacrifice: what is she keeping for herself?

(2008) Kiersten A Henderson et al.   CURRENT OPINION IN CELL BIOLOGY

Metabolic diversification of cells during the development of yeast colonies

(2008) Libuše Váchová et al.   ENVIRONMENTAL MICROBIOLOGY

Characterization of Differentiated Quiescent and Nonquiescent Cells in Yeast Stationary-Phase Cultures

(2008) Anthony D. Aragon et al.   MOLECULAR BIOLOGY OF THE CELL