The metabolically-modulated stem cell niche: a dynamic scenario regulating cancer cell phenotype and resistance to therapy

To breathe or not to breathe: the haematopoietic stem/progenitor cells dilemma

(2013) C Piccoli et al.   BRITISH JOURNAL OF PHARMACOLOGY

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

The Culture-Repopulating Ability Assays and Incubation in Low Oxygen: A Simple Way to Test Drugs on Leukaemia Stem or Progenitor Cells

(2013) Maria Cipolleschi et al.   CURRENT PHARMACEUTICAL DESIGN

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay

(2012) T. Fiaschi et al.   CANCER RESEARCH

Pericellular pH homeostasis is a primary function of the Warburg effect: Inversion of metabolic systems to control lactate steady state in tumor cells

(2012) Elizabeth A. Mazzio et al.   CANCER SCIENCE

Selection pressure exerted by imatinib therapy leads to disparate outcomes of imatinib discontinuation trials

(2012) M. Tang et al.   HAEMATOLOGICA

Low BCR-ABL expression levels in hematopoietic precursor cells enable persistence of chronic myeloid leukemia under imatinib

(2011) A. Kumari et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications

(2011) C Grimaldi et al.   LEUKEMIA

Hypoxia Selects Bortezomib-Resistant Stem Cells of Chronic Myeloid Leukemia

(2011) Michele Tanturli et al.   PLoS One

Acidic stress promotes a glioma stem cell phenotype

(2010) A B Hjelmeland et al.   CELL DEATH AND DIFFERENTIATION

Slow-cycling/quiescence balance of hematopoietic stem cells is related to physiological gradient of oxygen

(2010) Amélie V. Guitart et al.   EXPERIMENTAL HEMATOLOGY

Glucose availability in hypoxia regulates the selection of chronic myeloid leukemia progenitor subsets with different resistance to imatinib-mesylate

(2010) S. Giuntoli et al.   HAEMATOLOGICA

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

(2010) Amie S. Corbin et al.   JOURNAL OF CLINICAL INVESTIGATION

BCR-ABL kinase is dead; long live the CML stem cell

(2010) Alexander Perl et al.   JOURNAL OF CLINICAL INVESTIGATION

Proton dynamics in cancer

(2010) Veronica Huber et al.   Journal of Translational Medicine

Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial

(2010) François-Xavier Mahon et al.   LANCET ONCOLOGY

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(2010) Miguel Lopez-Lazaro   MOLECULAR MEDICINE

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT

Hypoxia or in situ normoxia: The stem cell paradigm

(2009) Zoran Ivanovic   JOURNAL OF CELLULAR PHYSIOLOGY

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Warburg Effect: Why and How Do Cancer Cells Activate Glycolysis in the Presence of Oxygen?

(2008) Miguel Lopez-Lazaro   Anti-Cancer Agents in Medicinal Chemistry

The Pervasive Presence of Fluctuating Oxygenation in Tumors

(2008) L. I. Cardenas-Navia et al.   CANCER RESEARCH

Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy

(2008) Akihiro Abe et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors

(2008) H Konig et al.   LEUKEMIA

Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells

(2008) Angela Colmone et al.   SCIENCE