The NAD+synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT-2) is a p53 downstream target

NAD Metabolism and Functions: A Common Therapeutic Target for Neoplastic, Metabolic and Neurodegenerative Diseases

(2015) Giuseppina Stefano et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Many Faces of Sirtuins: Coupling of NAD metabolism, sirtuins and lifespan

(2014) Eric Verdin   NATURE MEDICINE

p53 suppresses carcinoma progression by inhibiting mTOR pathway activation

(2014) N Akeno et al.   ONCOGENE

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

Metabolic Regulation by p53 Family Members

(2013) Celia R. Berkers et al.   Cell Metabolism

Sirtuin deacetylases in neurodegenerative diseases of aging

(2013) Adrianna Z Herskovits et al.   CELL RESEARCH

Senescence and aging: the critical roles of p53

(2013) A Rufini et al.   ONCOGENE

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

Poly(ADP-ribosyl)ation of p53 induces gene-specific transcriptional repression of MTA1

(2012) M-H Lee et al.   ONCOGENE

Nicotinamide Mononucleotide Adenylyltransferase 2 (Nmnat2) Regulates Axon Integrity in the Mouse Embryo

(2012) Amy N. Hicks et al.   PLoS One

CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

(2011) M. Cecilia Ljungberg et al.   HUMAN MOLECULAR GENETICS

NMNAT suppresses Tau-induced neurodegeneration by promoting clearance of hyperphosphorylated Tau oligomers in a Drosophila model of tauopathy

(2011) Yousuf O. Ali et al.   HUMAN MOLECULAR GENETICS

p53, Aerobic Metabolism, and Cancer

(2010) Cory U. Lago et al.   ANTIOXIDANTS & REDOX SIGNALING

Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies

(2010) Ahmed A Heikal   Biomarkers in Medicine

Shifting senescence into quiescence by turning up p53

(2010) Manuel Serrano   CELL CYCLE

Weak p53 permits senescence during cell cycle arrest

(2010) Olga V. Leontieva et al.   CELL CYCLE

The role of p53 in glucose metabolism

(2010) Eric C Cheung et al.   CURRENT OPINION IN CELL BIOLOGY

p53 at a glance

(2010) C. A. Brady et al.   JOURNAL OF CELL SCIENCE

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Paradoxical suppression of cellular senescence by p53

(2010) Z. N. Demidenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

(2010) Jonathan Gilley et al.   PLOS BIOLOGY

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Enzymes in the NAD+Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters

(2009) Tong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity

(2009) Tingting Yan et al.   NEUROCHEMISTRY INTERNATIONAL

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Paths of Convergence: Sirtuins in Aging and Neurodegeneration

(2008) Li Gan et al.   NEURON

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA