p53, Aerobic Metabolism, and Cancer

A dual role of p53 in the control of autophagy

(2014) Ezgi Tasdemir et al.   Autophagy

p53 represses autophagy in a cell cycle-dependent fashion

(2011) Ezgi Tasdemir et al.   CELL CYCLE

Stimulation of autophagy by the p53 target gene Sestrin2

(2010) Maria Chiara Maiuri et al.   CELL CYCLE

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial respiration protects against oxygen-associated DNA damage

(2010) Ho Joong Sung et al.   Nature Communications

Effect of Thioredoxin Deletion and p53 Cysteine Replacement on Human p53 Activity in Wild-Type and Thioredoxin Reductase Null Yeast

(2009) Christopher S. Stoner et al.   BIOCHEMISTRY

Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis

(2009) Maria A. Lebedeva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cardiorespiratory Fitness and Digestive Cancer Mortality: Findings from the Aerobics Center Longitudinal Study

(2009) J. B. Peel et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

PUMA- and Bax-induced autophagy contributes to apoptosis

(2009) K S Yee et al.   CELL DEATH AND DIFFERENTIATION

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

p53 Improves Aerobic Exercise Capacity and Augments Skeletal Muscle Mitochondrial DNA Content

(2009) Joon-Young Park et al.   CIRCULATION RESEARCH

Tumor protein 53 mutations and inherited cancer: beyond Li-Fraumeni syndrome

(2009) Edenir I Palmero et al.   CURRENT OPINION IN ONCOLOGY

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

Cardiorespiratory fitness, lifestyle factors and cancer risk and mortality in Finnish men

(2009) Jari A. Laukkanen et al.   EUROPEAN JOURNAL OF CANCER

Down-regulation of Bcl-2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum

(2009) Xing-Ding Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A Prospective Study of Cardiorespiratory Fitness and Breast Cancer Mortality

(2009) J. BRENT PEEL et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Function and biogenesis of iron–sulphur proteins

(2009) Roland Lill   NATURE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53

(2009) Tuck Seng Wong et al.   NUCLEIC ACIDS RESEARCH

Anticancer DNA intercalators cause p53-dependent mitochondrial DNA nucleoid re-modelling

(2009) N Ashley et al.   ONCOGENE

Polo-like kinases mediate cell survival in mitochondrial dysfunction

(2009) T. Matsumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase

(2009) K. Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical Activity and Cancer Prevention

(2009) Connie J Rogers et al.   SPORTS MEDICINE

Risk Stratification in Cancer Predisposition Syndromes: Lessons Learned from Novel Molecular Developments in Li-Fraumeni Syndrome

(2008) U. Tabori et al.   CANCER RESEARCH

p53 in mitochondria enhances the accuracy of DNA synthesis

(2008) M Bakhanashvili et al.   CELL DEATH AND DIFFERENTIATION

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Exercise in Prevention and Management of Cancer

(2008) Robert U. Newton et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

ROS and p53: A versatile partnership

(2008) Bin Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation

(2008) D. M. Burns et al.   GENES & DEVELOPMENT

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Mitochondrial DNA depletion syndrome due to mutations in the RRM2B gene

(2008) Belén Bornstein et al.   NEUROMUSCULAR DISORDERS

Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53

(2008) T. S. Wong et al.   NUCLEIC ACIDS RESEARCH

Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle

(2008) Ayesha Saleem et al.   PHYSIOLOGICAL GENOMICS

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE

Homeostatic functions of the p53 tumor suppressor: Regulation of energy metabolism and antioxidant defense

(2008) Ivan A. Olovnikov et al.   SEMINARS IN CANCER BIOLOGY