Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication

Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells

(2016) Asako J. Nakamura et al.   Aging-US

Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis

(2013) Libor Macurek et al.   CELL CYCLE

Down-regulation of Wild-type p53-induced Phosphatase 1 (Wip1) Plays a Critical Role in Regulating Several p53-dependent Functions in Premature Senescent Tumor Cells

(2013) Elvira Crescenzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Response to DNA damage: why do we need to focus on protein phosphatases?

(2013) Midori Shimada et al.   Frontiers in Oncology

Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells

(2012) H Yasaei et al.   ONCOGENE

Persistent Amplification of DNA Damage Signal Involved in Replicative Senescence of Normal Human Diploid Fibroblasts

(2012) Masatoshi Suzuki et al.   Oxidative Medicine and Cellular Longevity

DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization

(2011) Raffaella Di Micco et al.   CELL CYCLE

Pseudo-DNA damage response in senescent cells

(2011) Tatyana V. Pospelova et al.   CELL CYCLE

Regulation of the Wip1 phosphatase and its effects on the stress response Julie Lowe, Hyukjin Cha, Mi-Ok Lee, Sharlyn J. Mazur, Ettore Appella, Albert J. Fornace Jr.

(2011) Julie Lowe   Frontiers in Bioscience-Landmark

A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage

(2010) Luigi Carlessi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Wip1 Directly Dephosphorylates  -H2AX and Attenuates the DNA Damage Response

(2010) H. Cha et al.   CANCER RESEARCH

Phosphatases in the cellular response to DNA damage

(2010) Alyson K Freeman et al.   Cell Communication and Signaling

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Wild-type p53-induced Phosphatase 1 Dephosphorylates Histone Variant γ-H2AX and Suppresses DNA Double Strand Break Repair

(2010) Sung-Hwan Moon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wip1 phosphatase is associated with chromatin and dephosphorylates γH2AX to promote checkpoint inhibition

(2010) L Macůrek et al.   ONCOGENE

The Use of Gamma-H2AX as a Biodosimeter for Total-Body Radiation Exposure in Non-Human Primates

(2010) Christophe E. Redon et al.   PLoS One

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

(2009) Sairei So et al.   JOURNAL OF CELL BIOLOGY

Hypoxia or in situ normoxia: The stem cell paradigm

(2009) Zoran Ivanovic   JOURNAL OF CELLULAR PHYSIOLOGY

Formation of Dynamic γ-H2AX Domains along Broken DNA Strands Is Distinctly Regulated by ATM and MDC1 and Dependent upon H2AX Densities in Chromatin

(2009) Velibor Savic et al.   MOLECULAR CELL

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Expression, purification and use of recombinant annexin V for the detection of apoptotic cells

(2009) Susan E Logue et al.   Nature Protocols

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

(2008) Xiongbin Lu et al.   CANCER AND METASTASIS REVIEWS

ATR signaling can drive cells into senescence in the absence of DNA breaks

(2008) L. I. Toledo et al.   GENES & DEVELOPMENT

The JmjC Domain Histone Demethylase Ndy1 Regulates Redox Homeostasis and Protects Cells from Oxidative Stress

(2008) C. Polytarchou et al.   MOLECULAR AND CELLULAR BIOLOGY

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH

Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions

(2008) E. Soutoglou et al.   SCIENCE