SmgGDS-558 regulates the cell cycle in pancreatic, non-small cell lung, and breast cancers

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Targeting Mutant KRAS for Anticancer Therapeutics: A Review of Novel Small Molecule Modulators

(2013) Yuanxiang Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prenylation: From bacteria to eukaryotes

(2013) E. S. Marakasova et al.   MOLECULAR BIOLOGY

Cancer: Double-pronged approach to combat mutant KRAS

(2013) Alexandra Flemming   NATURE REVIEWS DRUG DISCOVERY

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

(2013) F. Shima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

‘Pathway drug cocktail’: targeting Ras signaling based on structural pathways

(2013) Ruth Nussinov et al.   TRENDS IN MOLECULAR MEDICINE

Mutant and Wild-type Ras: Co-conspirators in Cancer

(2013) Tikvah K. Hayes et al.   Cancer Discovery

The role of Rac1 in the regulation of NF-kB activity, cell proliferation, and cell migration in non-small cell lung carcinoma

(2012) Adam Gastonguay et al.   CANCER BIOLOGY & THERAPY

Inhibition of Tumor Promotion by Parthenolide: Epigenetic Modulation of p21

(2012) A. Ghantous et al.   Cancer Prevention Research

Ras/ERK1 pathway regulation of p27KIP1-mediated G1-phase cell-cycle arrest in cordycepin-induced inhibition of the proliferation of vascular smooth muscle cells

(2012) Su-Mi Jung et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-κB signaling pathway activation in vascular endothelial cells

(2011) Daiji Kawanami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SmgGDS Is a Guanine Nucleotide Exchange Factor That Specifically Activates RhoA and RhoC

(2011) Brant Hamel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein and its function based on a subcellular localization

(2011) Jana Ćmielová et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

PIK3CA Mutation Uncouples Tumor Growth and Cyclin D1 Regulation from MEK/ERK and Mutant KRAS Signaling

(2010) E. Halilovic et al.   CANCER RESEARCH

Ubiquitylation and proteasomal degradation of the p21Cip1, p27Kip1and p57Kip2CDK inhibitors

(2010) Zhimin Lu et al.   CELL CYCLE

Splice Variants of SmgGDS Control Small GTPase Prenylation and Membrane Localization

(2010) Tracy J. Berg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rac1 GTPase: A “Rac” of All Trades

(2009) E. E. Bosco et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer

(2009) Yang Liu et al.   LUNG CANCER

The Cyclin-Dependent Kinase Inhibitor p21 Is a Crucial Target for Histone Deacetylase 1 as a Regulator of Cellular Proliferation

(2009) G. Zupkovitz et al.   MOLECULAR AND CELLULAR BIOLOGY

Suppression of Cancer Cell Growth by Promoting Cyclin D1 Degradation

(2009) Jing Shan et al.   MOLECULAR CELL

SmgGDS is up-regulated in prostate carcinoma and promotes tumour phenotypes in prostate cancer cells

(2008) H Zhi et al.   JOURNAL OF PATHOLOGY

Role of Rho GTPases in breast cancer

(2007) Yong Tang   Frontiers in Bioscience-Landmark