GSI promotes vincristine-induced apoptosis by enhancing multi-polar spindle formation

Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1

(2013) Jia Lu et al.   CANCER CELL

Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer

(2013) Shinichi Yabuuchi et al.   CANCER LETTERS

The Notch signaling pathway as a mediator of tumor survival

(2013) K. M. Capaccione et al.   CARCINOGENESIS

Notch Pathway Activity Identifies Cells with Cancer Stem Cell-like Properties and Correlates with Worse Survival in Lung Adenocarcinoma

(2013) K. A. Hassan et al.   CLINICAL CANCER RESEARCH

Preclinical and Clinical Studies of Gamma Secretase Inhibitors with Docetaxel on Human Breast Tumors

(2013) A. F. Schott et al.   CLINICAL CANCER RESEARCH

Notch activation inhibits AML growth and survival: a potential therapeutic approach

(2013) Sankaranarayanan Kannan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synergistic Effect of the γ-Secretase Inhibitor PF-03084014 and Docetaxel in Breast Cancer Models

(2013) Cathy C. Zhang et al.   Stem Cells Translational Medicine

Crosstalk between PKCα and Notch-4 in endocrine-resistant breast cancer cells

(2013) J Yun et al.   Oncogenesis

Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells

(2012) Josep Domingo-Domenech et al.   CANCER CELL

Cisplatin Selects for Multidrug-Resistant CD133+ Cells in Lung Adenocarcinoma by Activating Notch Signaling

(2012) Y.-P. Liu et al.   CANCER RESEARCH

Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

(2012) Natalie Cook et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Contribution of Notch Signaling to Glioblastoma via Activation of Cancer Stem Cell Self-renewal

(2012) Demirkan B. Gürsel et al.   NEUROSURGERY

Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy

(2012) S. M. McAuliffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL

(2011) J. Tatarek et al.   BLOOD

Endothelial Cells Create a Stem Cell Niche in Glioblastoma by Providing NOTCH Ligands That Nurture Self-Renewal of Cancer Stem-Like Cells

(2011) T. S. Zhu et al.   CANCER RESEARCH

Mitosis-specific phosphorylation of amyloid precursor protein at Threonine 668 leads to its altered processing and association with centrosomes

(2011) Monique Judge et al.   Molecular Neurodegeneration

Centrosome clustering and chromosomal (in)stability: A matter of life and death

(2011) Alwin Krämer et al.   Molecular Oncology

Mitosis as an anti-cancer target

(2011) A Janssen et al.   ONCOGENE

NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer

(2010) S. S. Sikandar et al.   CANCER RESEARCH

Synthetic Lethality through Combined Notch-Epidermal Growth Factor Receptor Pathway Inhibition in Basal-Like Breast Cancer

(2010) Y. Dong et al.   CANCER RESEARCH

 -Secretase Inhibitors Enhance Temozolomide Treatment of Human Gliomas by Inhibiting Neurosphere Repopulation and Xenograft Recurrence

(2010) C. A. Gilbert et al.   CANCER RESEARCH

Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor

(2010) H. Harrison et al.   CANCER RESEARCH

Proteins Required for Centrosome Clustering in Cancer Cells

(2010) B. Leber et al.   Science Translational Medicine

Inhibition of Notch Signaling in Glioblastoma Targets Cancer Stem Cells via an Endothelial Cell Intermediate

(2010) Koos E. Hovinga et al.   STEM CELLS

Centrioles, Centrosomes, and Cilia in Health and Disease

(2009) Erich A. Nigg et al.   CELL

HAUS, the 8-Subunit Human Augmin Complex, Regulates Centrosome and Spindle Integrity

(2009) Steffen Lawo et al.   CURRENT BIOLOGY

Intramembrane-cleaving Proteases

(2009) Michael S. Wolfe   JOURNAL OF BIOLOGICAL CHEMISTRY

Centrosome function in cancer: guilty or innocent?

(2009) Deborah Zyss et al.   TRENDS IN CELL BIOLOGY

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

γ-Secretase Inhibitors Enhance Taxane-Induced Mitotic Arrest and Apoptosis in Colon Cancer Cells

(2007) Takashi Akiyoshi et al.   GASTROENTEROLOGY

Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy

(2006) Debrah I. Boeras et al.   NEUROBIOLOGY OF AGING