Article
Cell Biology
Rebecca J. Burgess, Zhiyu Zhao, Daisuke Nakada, Sean J. Morrison
Summary: The study showed that deficiency of Bmi1 leads to increased division of HSCs without inducing senescence. Bmi1 promotes HSC quiescence by negatively regulating ARX expression and promoting proteostasis by suppressing protein synthesis.
GENES & DEVELOPMENT
(2022)
Article
Medicine, Research & Experimental
Sana Siddiqui, Kristina Johansson, Alex Joo, Luke R. Bonser, Kyung Duk Koh, Olivier Le Tonqueze, Samaneh Bolourchi, Rodriel A. Bautista, Lorna Zlock, Theodore L. Roth, Alexander Marson, Nirav R. Bhakta, K. Mark Ansel, Walter E. Finkbeiner, David J. Erle, Prescott G. Woodruff
Summary: The study identifies miR-141 as a key regulator of pathological airway mucus production induced by IL-13, with disruption leading to decreased goblet cell frequency and reduced mucus secretion. This miRNA may offer a novel therapeutic target for airway diseases.
Article
Oncology
Chenglong Chen, Xingjia Mao, Caitong Cheng, Yurui Jiao, Yi Zhou, Tingting Ren, Zhuangzhuang Wu, Zhi Lv, Xiaojuan Sun, Wei Guo
Summary: The study revealed that miR-135a acts as a tumor suppressor in osteosarcoma by inhibiting tumor growth and metastasis, targeting BMI1/KLF4. This suggests a novel therapeutic approach for osteosarcoma treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Haoyang Zhou, Dafeng Yang, Henry S. Cheng, Michael G. McCoy, Daniel Perez-Cremades, Stefan Haemmig, Danny Wong, Lei Chen, Mark W. Feinberg
Summary: The study uncovers an important role of miR-181b in regulating vascular endothelial aging through the MAP3K3-MAPK signaling pathway, revealing potential therapeutic targets for anti-aging therapy in cardiovascular disease.
Review
Biochemistry & Molecular Biology
Amira Fitieh, Andrew J. Locke, Mobina Motamedi, Ismail Hassan Ismail
Summary: Polycomb group proteins play roles in stem cell maintenance, gene silencing, and DNA damage repair. BMI1, a member of PRC1, is involved in DNA repair and genome integrity, making it a potential pharmacological target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lea Toury, Diane Frankel, Coraline Airault, Frederique Magdinier, Patrice Roll, Elise Kaspi
Summary: miR-140-5p and miR-140-3p are miRNAs that are associated with the development and progression of cancers and aging-related diseases. They serve as predictive tools and play critical roles in the pathophysiology of aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Meiqing Liu, Ren Shen, Haoran Li, Yanwei Jia, Pui-In Mak, Rui P. Martins
Summary: miRNAs are important biomarkers for disease diagnosis and prognosis. DNA-AgNCs serve as a ratiometric fluorescent probe for miR-141 detection, offering higher sensitivity and single nucleotide specificity in miRNA assay.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Geriatrics & Gerontology
Sagar Vyavahare, Sandeep Kumar, Kathryn Smith, Bharati Mendhe, Roger Zhong, Marion A. Cooley, Babak Baban, Carlos M. Isales, Mark Hamrick, William Hill, Sadanand Fulzele
Summary: Emerging evidence suggests that microRNA-141-3p plays a role in age-related pathologies. In this study, we inhibited miR-141-3p expression in aged mice and observed improved immune, bone, and muscle health. Treatment with Anti-miR-141-3p resulted in decreased pro-inflammatory cytokines, a shift from pro-inflammatory to anti-inflammatory immune cell populations, and improved bone microstructure and muscle fiber size. Molecular analysis revealed the role of miR-141-3p in regulating senescence and inflammation, as well as its potential crosstalk with FOXO-1 transcription factor. These findings suggest that inhibiting miR-141-3p may be a potential strategy for promoting healthy aging.
Article
Cell Biology
Hyunjung Lee, Young In Kim, Farida S. Nirmala, Ji-Sun Kim, Hyo-Deok Seo, Tae Youl Ha, Young-Jin Jang, Chang Hwa Jung, Jiyun Ahn
Summary: Post-menopausal conditions exacerbate the biological aging process, leading to visceral adiposity and sarcopenia. Mitochondrial impairment, along with the upregulation of miR-141-3p and subsequent downregulation of Fkbp5 and Fibin, plays a role in the development of obesogenic sarcopenia. Inhibiting miR-141-3p could be a potential therapeutic target for alleviating this condition.
Article
Multidisciplinary Sciences
Ganghua Yang, Zhengyang Lu, Fandi Meng, Yong Wan, Lei Zhang, Qinhong Xu, Zheng Wang
Summary: This study aimed to investigate the biological function and diagnostic and prognostic value of miR-141 in gallbladder cancer (GBC). The results showed that miR-141 was highly expressed in GBC cells but lowly expressed in normal tissues. Elevated plasma miR-141 expression was also detected in GBC patients and could serve as a more valuable diagnostic biomarker for GBC. Moreover, high plasma miR-141 expression was closely associated with tumor invasion, lymph node metastasis, and advanced pathological TNM stage, and it was also an independent prognostic factor for predicting poorer survival in GBC patients. These findings suggest that miR-141 may be a potential biomarker for diagnosis, prognosis, and treatment of GBC.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Violette Azzoni, Julien Wicinski, Manon Macario, Martin Castagne, Pascal Finetti, Katerina Ambrosova, Celia D. Rouault, Arnaud Serge, Anne Farina, Emilie Agavnian, Sergiu Coslet, Emmanuelle Josselin, Arnaud Guille, Jose Adelaide, Emmanouil Zacharioudakis, Remy Castellano, Francois Bertucci, Daniel Birnbaum, Raphael Rodriguez, Emmanuelle Charafe-Jauffret, Christophe Ginestier
Summary: This study reveals the mechanism of breast cancer stem cells' response to replication stress and highlights the role of BMI1 protein in this process. Understanding this response is crucial for improving therapeutic resistance.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Juneyoung Lee, Attayeb Mohsen, Anik Banerjee, Louise D. McCullough, Kenji Mizuguchi, Motomu Shimaoka, Hiroshi Kiyono, Eun Jeong Park
Summary: The intestinal epithelium serves as a dynamic barrier that senses inflammatory signals in the gut environment, modulating phenotypic changes in response. With aging, dysregulation of miRNAs in intestinal epithelial cells is observed, leading to compromised barrier function and increased inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Yikai Liu, Zian Zhang, Xinzhe Lu, Chang Liu, Haining Zhang
Summary: Osteoarthritis (OA), a common disease in elderly individuals, is caused by cartilage degeneration. In this study, we identified miR-33-5p as a microRNA that promotes chondrocyte senescence and OA progression. We found that miR-33-5p expression was upregulated in senescence conditions and that it targeted SIRT6 mRNA. Additionally, miR-33-5p inhibition alleviated senescence induced by IL-1β. We also demonstrated the cartilage-destructive effect of miR-33-5p through intraarticular injection of agomiR-33-5p. Overall, miR-33-5p is a potential therapeutic target for treating OA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Xin Xin, Lian Duan, Huimin Yang, Hang Yu, Yandong Bao, Dalin Jia, Nan Wu, Ying Qiao
Summary: miR-141-3p is significantly upregulated in cardiomyocytes of obese rats induced by a high-fat diet, but its role in myocardial lipotoxicity remains unclear. The study shows that miR-141-3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through targeting PSEN1 and inhibiting the Notch1/PTEN/AKT pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Chemistry, Analytical
Yang Zang, Chengli Yu, Jingjing Jiang, Huaiguo Xue
Summary: In this study, a novel photoelectrochemical biosensor was developed for sensitive detection of miR-141. The biosensor showed excellent performance and great potential in clinical application.
MICROCHEMICAL JOURNAL
(2022)