Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control

Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells

(2015) Genevieve L. Weber et al.   Oncotarget

DNA Damage Response and Growth Factor Signaling Pathways in Gliomagenesis and Therapeutic Resistance

(2011) M. Squatrito et al.   CANCER RESEARCH

MRE11 and ATM AKTivate pro-survival signaling

(2011) Sarah E. Golding et al.   CELL CYCLE

ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks

(2011) Ashraf Khalil et al.   CELL CYCLE

MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks

(2011) Michael Fraser et al.   CELL CYCLE

DNA double-strand break – induced pro-survival signaling

(2011) Amy J. Hawkins et al.   RADIOTHERAPY AND ONCOLOGY

Inhibition of ATM kinase activity does not phenocopy ATM protein disruption

(2010) Serah Choi et al.   CELL CYCLE

Review on Quality of Life Issues in Patients with Primary Brain Tumors

(2010) M. J. B. Taphoorn et al.   ONCOLOGIST

Dynamic Dependence on ATR and ATM for Double-Strand Break Repair in Human Embryonic Stem Cells and Neural Descendants

(2010) Bret R. Adams et al.   PLoS One

Therapeutic options for recurrent malignant glioma

(2010) Maximilian Niyazi et al.   RADIOTHERAPY AND ONCOLOGY

Transient ATM Kinase Inhibition Disrupts DNA Damage-Induced Sister Chromatid Exchange

(2010) J. S. White et al.   Science Signaling

Cytotoxic Effects of Temozolomide and Radiation are Additive- and Schedule-Dependent

(2009) Anthony J. Chalmers et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

(2009) S. E. Golding et al.   MOLECULAR CANCER THERAPEUTICS

Transient Inhibition of ATM Kinase Is Sufficient to Enhance Cellular Sensitivity to Ionizing Radiation

(2008) M. D. Rainey et al.   CANCER RESEARCH

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

(2008) Martin F. Lavin   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE