MRE11 and ATM AKTivate pro-survival signaling

ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks

(2011) Ashraf Khalil et al.   CELL CYCLE

MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks

(2011) Michael Fraser et al.   CELL CYCLE

Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells

(2010) Sarah E. Golding et al.   CANCER BIOLOGY & THERAPY

The epidermal growth factor receptor modulates DNA double-strand break repair by regulating non-homologous end-joining

(2010) Malte Kriegs et al.   DNA REPAIR

EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma

(2009) B. Mukherjee et al.   CANCER RESEARCH

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

(2009) S. E. Golding et al.   MOLECULAR CANCER THERAPEUTICS

Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair

(2008) M. Toulany et al.   MOLECULAR CANCER THERAPEUTICS