CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD

Cilium, centrosome and cell cycle regulation in polycystic kidney disease

(2011) Kyung Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Apoptosis in polycystic kidney disease

(2011) Béatrice Goilav   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tolvaptan in Autosomal Dominant Polycystic Kidney Disease: Three Years' Experience

(2011) E. Higashihara et al.   Clinical Journal of the American Society of Nephrology

Inhibition of Cdc25A Suppresses Hepato-renal Cystogenesis in Rodent Models of Polycystic Kidney and Liver Disease

(2011) Tatyana V. Masyuk et al.   GASTROENTEROLOGY

Why kidneys fail in autosomal dominant polycystic kidney disease

(2011) Jared J. Grantham et al.   Nature Reviews Nephrology

Mechanism-Based Therapeutics for Autosomal Dominant Polycystic Kidney Disease: Recent Progress and Future Prospects

(2011) Ming-Yang Chang et al.   NEPHRON CLINICAL PRACTICE

Molecular Advances in Autosomal Dominant Polycystic Kidney Disease

(2010) Anna Rachel Gallagher et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Polycystic kidney disease: Pathogenesis and potential therapies

(2010) Vinita Takiar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Serum and urinary biomarker signatures for rapid preclinical in vivo assessment of CDK inhibition as a therapeutic approach for PKD

(2010) Sarah Moreno et al.   CELL CYCLE

Novel targets for the treatment of autosomal dominant polycystic kidney disease

(2010) Franck A Belibi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Rapamycin Ameliorates PKD Resulting from Conditional Inactivation of Pkd1

(2010) J. M. Shillingford et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Randomized Clinical Trial of Long-Acting Somatostatin for Autosomal Dominant Polycystic Kidney and Liver Disease

(2010) M. C. Hogan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

(2010) Thomas A Natoli et al.   NATURE MEDICINE

Sirolimus and Kidney Growth in Autosomal Dominant Polycystic Kidney Disease

(2010) Andreas L. Serra et al.   NEW ENGLAND JOURNAL OF MEDICINE

Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease

(2010) Gerd Walz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polycystins and Primary Cilia: Primers for Cell Cycle Progression

(2009) Jing Zhou   Annual Review of Physiology

A Case for Water in the Treatment of Polycystic Kidney Disease

(2009) V. E. Torres et al.   Clinical Journal of the American Society of Nephrology

Targeting Cyst Initiation in ADPKD

(2009) S. J. Leuenroth et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autosomal dominant polycystic kidney disease: the last 3 years

(2009) Vicente E. Torres et al.   KIDNEY INTERNATIONAL

Practical Synthesis of Roscovitine and CR8

(2009) Nassima Oumata et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Polycystic Kidney Disease

(2008) Peter C. Harris et al.   Annual Review of Medicine

Loss of polycystin-1 causes centrosome amplification and genomic instability

(2008) Lorenzo Battini et al.   HUMAN MOLECULAR GENETICS

Roscovitine-Derived, Dual-Specificity Inhibitors of Cyclin-Dependent Kinases and Casein Kinases 1

(2008) Nassima Oumata et al.   JOURNAL OF MEDICINAL CHEMISTRY

Src Inhibition Ameliorates Polycystic Kidney Disease

(2008) W. E. Sweeney et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases

(2008) K Bettayeb et al.   ONCOGENE