Article
Biochemistry & Molecular Biology
Peiling Wang, Xiangmei Hua, Yang Sun, Hongyu Li, Yuge Han Bryner, Richard P. Hsung, Jun Dai
Summary: Recent studies have shown that Haspin, a protein kinase essential for mitosis, plays a crucial role in the interphase progression of cancer cells. Loss of Haspin results in cell cycle defects, prolonging S/G2 phase, leading to mitotic cell death or postmitotic G1 arrest. Additionally, Haspin deficiency induces p21 checkpoint protein expression and co-depletion with p21 or p53 can partially restore cell proliferation.
Article
Oncology
Jiechao Yang, Qiang Huang, Yang Guo, Zheqiang Wei, Liang Zhou, Hui Chen
Summary: DIAPH1 is a protein closely related to cell cycle and mitosis, with its expression affecting overall survival in patients with laryngeal squamous cell carcinoma. It promotes cell proliferation and colony formation, and influences LSCC progression by regulating cell cycle signaling pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemical Research Methods
Luqi Jin, Yu Chen, Chunlan Yan, Xiaoyuan Guo, Tingting Jiang, Ayiding Guli, Xinghui Song, Qun Wan, Qiang Shu, Shiping Ding
Summary: The study shows that mTOR inhibition by rapamycin leads to the activation of CDK1, which further regulates cell cycle progression through the Greatwall-endosulfine complex. The research provides insights into the underlying mechanism of how mTOR influences cell cycle events.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Oncology
Letizia Clementi, Samantha Sabetta, Veronica Zelli, Chiara Compagnoni, Alessandra Tessitore, Vincenzo Mattei, Adriano Angelucci
Summary: This study investigated the expression of phosphorylated Tau in prostate cancer cell lines and found that Tau protein is phosphorylated at residue Thr231 during the G2/M cell cycle phase. The phosphorylation status of Tau is controlled by cdk5 and PP2A, and can affect the resistance of cells to drug toxicity. Modulation of Tau phosphorylation may interfere with the progression of cells through the G2/M phase.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Siobhan O'Brien, Susan Kelso, Zachary Steinhart, Stephen Orlicky, Monika Mis, Yunhye Kim, Sichun Lin, Frank Sicheri, Stephane Angers
Summary: This study reports a novel synthetic lethal genetic interaction between FBXW7 and CCNL1 and identifies CCNL1 as a substrate of the SCF-FBXW7 E3 ligase. Defective CCNL1 accumulation resulting from FBXW7 mutation leads to shorter mitotic time. Cells with FBXW7 loss-of-function mutations are highly sensitive to treatment with a CDK11 inhibitor, suggesting a potential genetic vulnerability for cancer treatment.
Article
Biochemistry & Molecular Biology
Belen Sanz-Castillo, Begona Hurtado, Diana Vara-Ciruelos, Aicha El Bakkali, Dario Hermida, Beatriz Salvador-Barbero, Diego Martinez-Alonso, Jose Gonzalez-Martinez, Clara Santiveri, Ramon Campos-Olivas, Pilar Ximenez-Embun, Javier Munoz, Monica Alvarez-Fernandez, Marcos Malumbres
Summary: This study reveals that the cell cycle kinase MASTL/Greatwall inhibits the activity of the PI3K-AKT signaling pathway by phosphorylating the PP2A/B55 inhibitor ENSA/ARPP19, thus limiting AKT activity. Furthermore, the study finds that MASTL is directly phosphorylated by mTORC1, which limits the dephosphorylation of IRS1 and GRB10 downstream of mTORC1, further restraining AKT activity. This research highlights the importance of the MASTL-PP2A/B55 kinase-phosphatase module in controlling AKT and maintaining metabolic homeostasis.
Article
Cell Biology
Maria Di Bari, Vanessa Tombolillo, Francesco Alessandrini, Claudia Guerriero, Mario Fiore, Italia Anna Asteriti, Emilia Castigli, Miriam Sciaccaluga, Giulia Guarguaglini, Francesca Degrassi, Ada Maria Tata
Summary: The study reveals that the M2 agonist increases aberrant mitosis in glioblastoma cell lines, suggesting it may be a promising novel therapeutic target for glioblastoma treatment.
Article
Biochemistry & Molecular Biology
Leonor Delgado, Paula Brilhante-Simoes, Fernanda Garcez, Luis Monteiro, Isabel Pires, Justina Prada
Summary: p-mTOR and p-S6 proteins are commonly expressed in canine oral squamous cell carcinoma (OSCC), and p-S6 expression is correlated with poor cancer-specific survival (CSS) in dogs with OSCC.
Article
Cell Biology
Sheikh Tahir Majeed, Asiya Batool, Rabiya Majeed, Nadiem Nazir Bhat, Muhammad Afzal Zargar, Khurshid Iqbal Andrabi
Summary: Phosphorylated S209-eIF4E interacts with the TOS motif of S6K1, releasing it from auto-inhibition and priming it for activation in an mTORC1-independent manner. The role of mTORC1 is limited to engaging eIF4E with the S6K1-TOS motif to influence S6K1's state of activation.
Article
Biochemistry & Molecular Biology
Xiaofeng Zuo, Peixin Meng, Yuxin Bao, Chuntao Tao, Yitao Wang, Xianjun Liu, Youquan Bu, Jiang Zhu
Summary: In this study, four independent NPC transcriptomic datasets were systematically analyzed to identify the critical molecular networks and novel key hub genes involved in NPC. The results revealed that cell cycle dysregulation is a critical event in NPC, and KIF2C was identified as a central regulator in a 15 hub-gene core network. Functional studies showed that knockdown of KIF2C inhibited cell growth and motility, delayed cell cycle progression, and resulted in mitotic defects in spindle formation in NPC cells. Furthermore, KIF2C was found to regulate the AKT/mTOR pathways and enhance paclitaxel sensitivity in NPC cells.
Article
Cell Biology
Xiao Zhang, Huahui Wu, Xin Yan, Jiajun Ma, Zhao Chen
Summary: This study investigated the action mechanism of LTB4R in renal clear cell carcinoma and found that LTB4R plays an oncogenic role in the cancer. It may serve as a potential molecular target for treatment and a predictive biomarker for prognosis.
Review
Cell Biology
Siamak A. Kamranvar, Bhavna Rani, Staffan Johansson
Summary: Cell cycle and cell adhesion are interdependent cellular processes that regulate each other through signaling pathways. Recent studies have shown that integrin-mediated cell adhesion plays an important role in the regulation of the cell cycle, particularly during the G2 and early M phases.
Review
Biochemistry & Molecular Biology
Jimena Druker, James W. Wilson, Fraser Child, Dilem Shakir, Temitope Fasanya, Sonia Rocha
Summary: The cell cycle is a crucial cellular process for genome replication, with mechanisms needed to respond to stress signals like hypoxia. This review discusses the interplay between transcriptional and post-transcriptional mechanisms initiated under hypoxia and cell cycle control. Overall, the relationship between the cellular response to hypoxia and the cell cycle ensures survival and minimizes errors during cell division.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Danielle Shevah-Sitry, Shirly Miniowitz-Shemtov, Adar Teichner, Sharon Kaisari, Avram Hershko
Summary: The ubiquitin ligase APC/C plays a crucial role in the control of mitosis. The phosphorylation of Cdc20 and its interaction with APC/C are important for its function in mitosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Sharon Kaisari, Shirly Miniowitz-Shemtov, Danielle Sitry-Shevah, Pnina Shomer, Guennadi Kozlov, Kalle Gehring, Avram Hershko
Summary: The mitotic checkpoint system ensures accurate chromosome segregation in mitosis. UBR5 is a protein associated with mitotic checkpoint proteins and plays a role in regulating the inactivation of the mitotic checkpoint.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Neurosciences
Gabor Egervari, Tanni Rahman
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Biochemistry & Molecular Biology
M. L. Miller, Y. Ren, H. Szutorisz, N. A. Warren, C. Tessereau, G. Egervari, A. Mlodnicka, M. Kapoor, B. Chaarani, C. V. Morris, G. Schumann, H. Garavan, A. M. Goate, M. J. Bannon, J. M. Halperin, Y. L. Hurd
MOLECULAR PSYCHIATRY
(2018)
Article
Neurosciences
Michael Michaelides, Michael L. Miller, Jennifer A. DiNieri, Juan L. Gomez, Elizabeth Schwartz, Gabor Egervari, Gene Jack Wang, Charles V. Mobbs, Nora D. Volkow, Yasmin L. Hurd
NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Biochemistry & Molecular Biology
John F. Fullard, Mads E. Hauberg, Jaroslav Bendl, Gabor Egervari, Maria-Daniela Cirnaru, Sarah M. Reach, Jan Motl, Michelle E. Ehrlich, Yasmin L. Hurd, Panos Roussos
Review
Biochemistry & Molecular Biology
Gabor Egervari, Alexey Kozlenkov, Stella Dracheva, Yasmin L. Hurd
MOLECULAR PSYCHIATRY
(2019)
Article
Biochemistry & Molecular Biology
Michael Michaelides, Michael L. Miller, Gabor Egervari, Stefany D. Primeaux, Juan L. Gomez, Randall J. Ellis, Joseph A. Landry, Henrietta Szutorisz, Alexander F. Hoffman, Carl R. Lupica, Ruth J. F. Loos, Panayotis K. Thanos, George A. Bray, John F. Neumaier, Venetia Zachariou, Gene-Jack Wang, Nora D. Volkow, Yasmin L. Hurd
MOLECULAR PSYCHIATRY
(2020)
Review
Cell Biology
Xinjian Li, Gabor Egervari, Yugang Wang, Shelley L. Berger, Zhimin Lu
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2018)
Article
Behavioral Sciences
Gabor Egervari, Roberto Ciccocioppo, J. David Jentsch, Yasmin L. Hurd
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2018)
Article
Multidisciplinary Sciences
P. Mews, G. Egervari, R. Nativio, S. Sidoli, G. Donahue, S. I. Lombroso, D. C. Alexander, S. L. Riesche, E. A. Heller, E. J. Nestler, B. A. Garcia, S. L. Berger
Article
Multidisciplinary Sciences
Gabor Egervari, Diana Akpoyibo, Tanni Rahman, John F. Fullard, James E. Callens, Joseph A. Landry, Annie Ly, Xianxiao Zhou, Noel Warren, Mads E. Hauberg, Gabriel Hoffman, Randy Ellis, Jacqueline-Marie N. Ferland, Michael L. Miller, Eva Keller, Bin Zhang, Panos Roussos, Yasmin L. Hurd
NATURE COMMUNICATIONS
(2020)
Review
Behavioral Sciences
Gabor Egervari
Summary: Epigenetic mechanisms play a critical role in regulating brain function by controlling gene accessibility and expression, leading to changes in neuronal function. New methods for directly detecting chromatin accessibility have generated valuable insights. Studying chromatin states in the brain can enhance our understanding of disease development mechanisms.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Review
Neurosciences
Gabor Egervari, Cody A. Siciliano, Ellanor L. Whiteley, Dorit Ron
Summary: Alcohol use has diverse effects on the central nervous system, influencing gene expression, signaling mechanisms, and neuronal circuit activity. These mechanisms result in long-lasting cellular adaptations in the brain, which may drive the development and maintenance of alcohol use disorder.
TRENDS IN NEUROSCIENCES
(2021)
Article
Multidisciplinary Sciences
Mariel Mendoza, Gabor Egervari, Simone Sidoli, Greg Donahue, Desi C. Alexander, Payel Sen, Benjamin A. Garcia, Shelley L. Berger
Summary: This study reveals the regulation of histone acetylation by nuclear acetyl-CoA pools and suggests a local transfer of acetate occurs during gene activation. The yeast ortholog of ACSS2, Acs2, is recruited to chromatin during quiescence exit and is preferentially associated with the most up-regulated genes, indicating the important role of acetyl group transfer in gene activation.
Editorial Material
Multidisciplinary Sciences
Gabor Egervari, Karl M. Glastad, Shelley L. Berger
Article
Neurosciences
Gabor Egervari, Joseph Landry, James Callens, John F. Fullard, Panos Roussos, Eva Keller, Yasmin L. Hurd
BIOLOGICAL PSYCHIATRY
(2017)