Article
Pharmacology & Pharmacy
Tsugunobu Andoh, Yoko Yoshihisa, Mati Ur Rehman, Yoshiaki Tabuchi, Tadamichi Shimizu
Summary: The study found that berberine has a certain ameliorative effect on the AD-like symptoms in mice, acting by inhibiting the expression of inflammatory factors and the recruitment of inflammatory cells.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fangyuan Cao, Zhangping Xiao, Siwei Chen, Chunlong Zhao, Deng Chen, Hidde J. Haisma, Frank J. Dekker
Summary: A novel dual inhibitor targeting HDAC and MIF was found to be toxic to EGFR mutated NSCLC cells, enhancing TKI efficacy and overcoming therapy resistance.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yannick Audet-Delage, Michele Rouleau, Lyne Villeneuve, Chantal Guillemette
Summary: Nucleotide sugar-dependent glycosyltransferases (UGTs) play critical roles in cellular metabolism, and this study reveals the impact of UGT expression on cellular metabolism. The expression of UGTs leads to modifications in multiple biochemical pathways, affecting glycolysis, pyrimidine pathways, and precursors of UDP-glucuronic acid metabolism. Furthermore, alternative splicing-derived isoforms of UGTs induce unique metabolic perturbations and extensive connectivity with other metabolic processes.
Article
Immunology
Zijian Liu, Zhihao Li, Guozhi Yan, Can Lin, Yaosheng Luo, Yanshi Ye, Xiaokang Zeng, Jie Yao
Summary: We found that MIF, IL-17A, and HVEM were up-regulated in HT patients, and the proportion of Th17 cells was positively correlated with the serum MIF protein level. Further studies showed that MIF promotes Th17 cell differentiation through HVEM and NF-kappa B signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Avinash Gupta, Dolly Sharma, Harshita Gupta, Ajeet Singh, Daipayan Chowdhury, Lilly Ganju, Ramesh Chand Meena
Summary: This study investigated the molecular pathway regulation of liver damage caused by heat stress. The results showed major changes in redox status, inflammation, mitochondrial dysfunction, and proteostasis related pathways during severe heat stress. The analysis of molecular pathways revealed that the oxidative stress response mediated by nuclear factor erythroid 2-related factor 2 (NRF-2) and the inflammatory pathways regulated by macrophage migration inhibitory factor (MIF) were upregulated in the severely heat-stressed liver.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Ali Ahmadizad Firouzjaei, Kazem Sharifi, Majid Khazaei, Samira Mohammadi-Yeganeh, Seyed Hamid Aghaee-Bakhtiari
Summary: This study aims to investigate the interaction between miRNAs and mRNAs in regulating the cell cycle in colorectal cancer (CRC) patients. By utilizing KEGG, GEO, and TTD databases, cell cycle-associated genes were identified and evaluated. Seven differentially expressed genes (DEGs) were identified as potential therapeutic targets, and docking experiments with selected drugs confirmed their suitability for targeting cell cycle DEGs. miRNAs targeting these genes were found using Tarbase, miRTarbase, miRDIP, and miRCancer databases. These downregulated miRNAs in SW480 cells may impact the cell cycle in colorectal cancer. The study suggests that bioinformatics tools can facilitate the identification of miRNAs influencing mRNA translation at different stages of the cell cycle, which can be further investigated as targets for cell cycle arrest in cancers.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Medicine, Research & Experimental
Hailang Fan, Lairong Song, Jian Fan, Junpeng Ma, Xiaojie Li, Junting Zhang, Jian Hu, Zhen Wu, Dake Zhang, Liang Wang
Summary: Analyzing meningioma of distinct pathological types at the single-cell level reveals high heterogeneity and diverse biological functions within neoplastic cells. Proliferative neoplastic cells may educate macrophages, promoting tumorigenesis possibly through the MIF-CD74 interaction, offering novel insights for potential therapeutic avenues.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yuriki Sakurai, Kyungmin Baeg, Andy Y. W. Lam, Keisuke Shoji, Yukihide Tomari, Hiro-oki Iwakawa
Summary: This study uncovers the molecular mechanisms underlying the production of secondary siRNAs in plants, and highlights the impact of the integrity of different small RNA binding sites on RDR6.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Kangtao Jin, Lin Zheng, Lin Ye, Ziang Xie, Jiawei Gao, Chao Lou, Wenzheng Pan, Bin Pan, Shijie Liu, Zhenzhong Chen, Dengwei He
Summary: The study demonstrates that CSB6B suppresses osteoclast differentiation and bone resorption while enhancing osteoblast mineralization by inhibiting the NF-KB pathway and promoting Runx expression. In murine models, CSB6B has shown protective effects against pathological bone destruction and bone loss induced by estrogen deficiency. MIF inhibition by CSB6B could be a potential therapeutic approach for osteolytic bone disorders and osteoporosis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Yan-ming Chen, Qiong Zhu, Jie Cai, Zhi-jia Zhao, Bin-bin Yao, Li-ming Zhou, Lin-dan Ji, Jin Xu
Summary: This study investigated the role of circRNAs in gestational diabetes mellitus (GDM) by analyzing the differentially expressed circRNAs and their target mRNAs in GDM patients and healthy pregnant women. The findings suggest that upregulation of the T cell receptor signaling pathway may play a major role in the pathogenesis of GDM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ruyi Li, Peng Song, Guofang Tang, Jianghong Wei, Lizong Rao, Libing Ma, Ming Jiang, Jianwei Huang, Qing Xu, Jingjie Wu, Qian Lv, Dong Yao, Bo Xiao, Haiming Huang, Liping Lei, Juntao Feng, Biwen Mo
Summary: Osthole alleviates macrophage activation in asthma by suppressing the NF-κB/MIF signaling pathway, showing potential as a therapeutic agent for asthma.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Yan Li, Chengyu Zou, Chen Chen, Sixuan Li, Ziyu Zhu, Qiuyue Fan, Rui Pang, Fengshi Li, Zengai Chen, Zhenghong Wang, Weifeng Yu, Junying Yuan, Peiying Li
Summary: This study demonstrates that macrophage migration inhibitory factor (MIF) promotes endothelial cell (EC) death under inflammatory conditions, thus contributing to blood-brain barrier disruption.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Oncology
Yi Xiao, Jixin Dong
Summary: The article emphasizes that cancer is increasingly viewed as a cell cycle disease, introducing the role of the Hippo pathway in cell cycle regulation, and discussing the impact of cell cycle dysregulation on cancer development.
Article
Biochemistry & Molecular Biology
Ane Elexpe, Laura Sanchez-Sanchez, Tarson Tolentino-Cortez, Egoitz Astigarraga, Maria Torrecilla, Gabriel Barreda-Gomez
Summary: Drug side effects are a major reason for treatment withdrawal in clinical trials. This study evaluated the formation of reactive oxygen species (ROS) in cell membranes of various drugs and compounds with different properties. The findings suggest that some drugs directly affect mitochondrial complex I and that ROS formation may anticipate adverse effects.
Article
Biochemistry & Molecular Biology
Warren B. Nothnick, Amanda Graham
Summary: Endometriosis is a complicated disease characterized by pain and infertility, with unclear pathogenesis and pathophysiology. Rodent models have been developed to study its pathogenesis. In this study, the miR-451a-Mif pathway was evaluated, revealing the role of Mif receptors, Cd74 and Cxcr4, in the pathophysiology of endometriosis.