Inflammation and pancreatic cancer: molecular and functional interactions between S100A8, S100A9, NT-S100A8 and TGFβ1

TLR4 Mediates MAPK–STAT3 Axis Activation in Bladder Epithelial Cells

(2013) Huang Ying et al.   INFLAMMATION

Suppression of AKT Phosphorylation Restores Rapamycin-Based Synthetic Lethality in SMAD4-Defective Pancreatic Cancer Cells

(2013) Onica Le Gendre et al.   MOLECULAR CANCER RESEARCH

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Response gene to complement-32 enhances metastatic phenotype by mediating transforming growth factor beta-induced epithelial-mesenchymal transition in human pancreatic cancer cell line BxPC-3

(2012) Liang Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers

(2012) C Freudlsperger et al.   ONCOGENE

European cancer mortality predictions for the year 2011

(2011) M. Malvezzi et al.   ANNALS OF ONCOLOGY

Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression

(2011) Mario A. Shields et al.   BIOCHEMICAL JOURNAL

Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms

(2011) Qian Qin et al.   CELL RESEARCH

Uncapping NF-κB activity in pancreatic cancer

(2011) Sushma Gurumurthy et al.   EMBO JOURNAL

Transforming Growth Factor-β in the Gastrointestinal and Hepatic Tumor Microenvironment

(2011) Bhagelu Ram Achyut et al.   GASTROENTEROLOGY

S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner

(2011) F. Riuzzi et al.   JOURNAL OF CELL SCIENCE

Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma

(2011) Hideaki Ijichi et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Pathogenesis of Pancreatic Cancer and Clinical Perspectives

(2011) D. Matthaios et al.   ONCOLOGY

PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network

(2011) Haoqiang Ying et al.   Cancer Discovery

Inflammation-associated S100 proteins: new mechanisms that regulate function

(2010) Jesse Goyette et al.   AMINO ACIDS

Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells

(2010) Chin Wee Ang et al.   CARCINOGENESIS

Transcriptional crosstalk between TGFβ and stem cell pathways in tumor cell invasion: Role of EMT promoting Smad complexes

(2010) Jonas Fuxe et al.   CELL CYCLE

Mammalian target of rapamycin (mTOR) phosphorylates inositol 1,4,5-trisphosphate receptor type 2 and increases its Ca2+ release activity

(2010) Yannik Régimbald-Dumas et al.   CELLULAR SIGNALLING

Thapsigargin-induced Ca2+ increase inhibits TGFβ1-mediated Smad2 transcriptional responses via Ca2+/calmodulin-dependent protein kinase II

(2010) Ming Ming et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Transforming growth factor-β induces epithelial to mesenchymal transition and suppresses the proliferation and transdifferentiation of cultured human pancreatic duct cells

(2010) Jeong-Ah Shin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Positive regulation of inositol 1,4,5-trisphosphate-induced ca2+release by mammalian target of rapamycin (mTOR) in RINm5F cells

(2010) Marc-Olivier Frégeau et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Extracellular calcium sensing receptor stimulation in human colonic epithelial cells induces intracellular calcium oscillations and proliferation inhibition

(2010) Osvaldo Rey et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Altered intracellular calcium fluxes in pancreatic cancer induced diabetes mellitus: Relevance of the S100A8 N-terminal peptide (NT-S100A8)

(2010) Daniela Basso et al.   JOURNAL OF CELLULAR PHYSIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pancreatic Cancer

(2010) Manuel Hidalgo   NEW ENGLAND JOURNAL OF MEDICINE

Ukrain Affects Pancreas Cancer Cell Phenotype in vitro by Targeting MMP-9 and Intra-/Extracellular SPARC Expression

(2010) Niccola Funel et al.   PANCREATOLOGY

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

The receptor RAGE: Bridging inflammation and cancer

(2009) Astrid Riehl et al.   Cell Communication and Signaling

SMAD4 Gene Mutations Are Associated with Poor Prognosis in Pancreatic Cancer

(2009) A. Blackford et al.   CLINICAL CANCER RESEARCH

S100A8/A9: A Janus-faced molecule in cancer therapy and tumorgenesis

(2009) Saeid Ghavami et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epidermal growth factor receptor ligands as new extracellular targets for the metastasis-promoting S100A4 protein

(2009) Jörg Klingelhöfer et al.   FEBS Journal

DPC4 Gene Status of the Primary Carcinoma Correlates With Patterns of Failure in Patients With Pancreatic Cancer

(2009) Christine A. Iacobuzio-Donahue et al.   JOURNAL OF CLINICAL ONCOLOGY

The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer

(2009) Jan M. Ehrchen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice

(2009) X Xu et al.   ONCOGENE

Pancreatic Cancer

(2008) Anirban Maitra et al.   Annual Review of Pathology-Mechanisms of Disease

RAGE signaling sustains inflammation and promotes tumor development

(2008) Christoffer Gebhardt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE