Article
Nanoscience & Nanotechnology
Aparna Nandakumar, Wei Wei, Ghizal Siddiqui, Huayuan Tang, Yuhuan Li, Aleksandr Kakinen, Xulin Wan, Kairi Koppel, Sijie Lin, Thomas P. Davis, David T. Leong, Darren J. Creek, Feng Ding, Yang Song, Pu Chun Ke
Summary: This study investigated the protein coronae associated with gold nanoparticles of different shapes and found distinct differences in protein composition, shedding light on the implications for future nanomedicine research.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Myeongsang Lee, Nengyi Ni, Huayuan Tang, Yuhuan Li, Wei Wei, Aleksandr Kakinen, Xulin Wan, Thomas P. Davis, Yang Song, David Tai Leong, Feng Ding, Pu Chun Ke
Summary: This study comprehensively examined the characteristics of NanoEL phenomenon, revealing the nano-scale interactions between nanoparticles and VE-cadherin and its intra/extracellular cofactors. Utilizing computational simulation methods, it also revealed the molecular and statistical mechanics of cadherin disruption by the smallest size and highest concentration of AuNPs for the first time.
Article
Engineering, Biomedical
Nengyi Ni, Weiyi Wang, Yu Sun, Xiao Sun, David Tai Leong
Summary: Intravenous delivered nanomedicine needs to escape from the blood vessel to exert therapeutic effects. While many powerful anticancer nanomedicine strategies rely on the tumor-derived enhanced permeability and retention (EPR) effect for escaping, it is not applicable to all tumors. Recent advancements have been made in inducing endothelial leakiness at the tumor to decrease reliance on EPR.
Review
Oncology
Delphine Trochet, Marc Bitoun
Summary: DNM2 plays a crucial role in cancer by promoting cell migration, invasion, metastasis, as well as tumor cell proliferation and survival. Therapeutic targeting of DNM2 has shown promising results in reducing cell proliferation, inducing apoptosis, and reducing invasive phenotype in cancer cells, both in vitro and in vivo animal models.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Wei Wei, Yuhuan Li, Myeongsang Lee, Nicholas Andrikopoulos, Sijie Lin, Chunying Chen, David Tai Leong, Feng Ding, Yang Song, Pu Chun Ke
Summary: The production of plastics has played a crucial role in modern society, but the accumulation of plastics in the environment poses a significant threat to environmental sustainability and human health. This study focuses on the biological effects of nanoplastics, specifically anionic polystyrene and poly(methyl methacrylate), and reports that their introduction disrupts the vascular endothelial cadherin junctions. The findings provide important insights into the behavior and impact of nanoplastics, which can guide innovations for a sustainable plastics industry and environmental remediation.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Lucas Bayones, Maria Jose Guerra-Fernandez, Fernando Hinostroza, Ximena Baez-Matus, Jacqueline Vasquez-Navarrete, Luciana Gallo, Sergio Parra, Agustin D. Martinez, Arlek Gonzalez-Jamett, Fernando D. Marengo, Ana M. Cardenas
Summary: Gain-of-function mutations of dynamin-2 result in centronuclear myopathy by impairing exocytosis, disrupting actin filament formation and impacting the plasmalemma expression of functional proteins in skeletal muscle cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Magdiel Inggrid Setyawati, Qin Wang, Nengyi Ni, Jie Kai Tee, Katsuhiko Ariga, Pu Chun Ke, Han Kiat Ho, Yucai Wang, David Tai Leong
Summary: Traditional nanomedicine relies on tumor induced EPR effect for drug delivery. Here the authors show that gold nanoparticles are independently able to induce leakiness at tumor vasculature to enhance the tumor killing effect.
NATURE COMMUNICATIONS
(2023)
Review
Nanoscience & Nanotechnology
Magdalena Lasak, Karol Ciepluch
Summary: Nanoparticles with unique physicochemical properties can overcome biological barriers and are considered one of the best materials with anticancer properties. The interaction of nanoparticles with the endothelium can lead to nanoparticle-modulated endothelial leakiness (NanoEL), which can be beneficial for drug delivery but also carries risks. Understanding the mechanism and degree of induction of NanoEL, as well as the potential risks, is crucial for the development of effective therapeutic strategies.
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2023)
Article
Peripheral Vascular Disease
Qianqian Wang, Jingjing Tian, Xuan Li, Xiaolin Liu, Tengfei Zheng, Yachao Zhao, Xiao Li, Hongyu Zhong, Dongdong Liu, Wencheng Zhang, Meng Zhang, Mengmeng Li, Mei Zhang
Summary: This study found that DKK1 was upregulated in patients with PH, hypoxia-induced PH mice, and human pulmonary artery endothelial cells. DKK1 regulated SHMT2 transcription, impacting cellular metabolism and mitochondrial function, leading to a proproliferative and antiapoptotic phenotype in endothelial cells. Treatment with a neutralizing anti-DKK1 antibody showed potential in attenuating PH.
Article
Peripheral Vascular Disease
Shu-Song Du, Xue Sun, Jie Cen, Jun-Xiu Shi, Ming-Xin An, Wei-Dong Zhao
Summary: This study investigated the expression profiles of dynamin isoforms and their roles in endocytosis in brain endothelial cells. Dyn2 was found to be the highest expressed isoform, and it was necessary for transferrin uptake and played a role in the late stage of vesicle fission during endocytosis. The results suggested that Dyn2 mediates clathrin-dependent endocytosis for amyloid-beta internalization from basolateral to apical side into brain endothelial cells, while Dyn1 and Dyn3 did not have the same role.
MICROVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Harmonie Perdreau-Dahl, David B. Lipsett, Michael Frisk, Fatemeh Kermani, Cathrine R. Carlson, Andreas Brech, Xin Shen, Anna Bergan-Dahl, Yufeng Hou, Tomi Tuomainen, Pasi Tavi, Peter P. Jones, Marianne Lunde, J. Andrew Wasserstrom, Jocelyn Laporte, Nina D. Ullrich, Geir Christensen, J. Preben Morth, William E. Louch
Summary: This study reveals the collaborative roles of BIN1, MTM1, and DNM2 in controlling t-tubule growth in cardiomyocytes, which is crucial for the maturation of cardiomyocyte Ca2+ homeostasis.
CIRCULATION RESEARCH
(2023)
Review
Geriatrics & Gerontology
Yuying Guan, Jia Liu, Yakun Gu, Xunming Ji
Summary: Cerebrovascular microcirculation is crucial for brain function, and angiogenesis plays a significant role in remodeling the microcirculation. Hypoxia is an important regulator of angiogenesis, but it also negatively affects cerebral vascular tissue. Establishing a model that promotes cerebral microvasculogenesis without causing injury is essential.
Article
Biochemistry & Molecular Biology
Jianzhen Li, Kenshiro Fujise, Haymar Wint, Yosuke Senju, Shiro Suetsugu, Hiroshi Yamada, Kohji Takei, Tetsuya Takeda
Summary: Research has identified dynamin 2 and pacsine 2 as functional partners in podosomes of Src-transformed NIH 3T3 cells, co-operatively regulating the organization of podosomes. They interact and promote each other's localization at podosomes, thereby affecting podosome formation and maturation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Eriko Hamasaki, Natsuki Wakita, Hiroki Yasuoka, Hikaru Nagaoka, Masayuki Morita, Eizo Takashima, Takayuki Uchihashi, Tetsuya Takeda, Tadashi Abe, Ji-Won Lee, Tadahiro Iimura, Moin A. Saleem, Naohisa Ogo, Akira Asai, Akihiro Narita, Kohji Takei, Hiroshi Yamada
Summary: This study investigates the molecular mechanisms underlying the regulation of actin by dynamin in human podocytes. The results suggest that the affinity of the K562E mutant for lipid membranes and its atypical self-assembling properties lead to actin disorganization in podocytes. Furthermore, the interaction between actin and membranes mediated by dynamin is critical for actin bundle formation and podocyte morphology and functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Cell Biology
Ludger Johannes, Cesar Augusto Valades-Cruz
Summary: This study reveals that invaginated clathrin-coated endocytic pits undergo a strong rotational twist prior to or concomitant with their detachment, which may depend on the 'pinchase' activity of dynamin.
NATURE CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Vino T. Cheriyan, Mabruka Alfaidi, Ashton N. Jorgensen, Md Ashiqul Alam, Chowdhury S. Abdullah, Gopi K. Kolluru, Shenuarin Bhuiyan, Christopher G. Kevil, A. Wayne Orr, Hyung W. Nam
Article
Biochemistry & Molecular Biology
Megan Watts, Gopi K. Kolluru, Parinita Dherange, Sibile Pardue, Man Si, Xinggui Shen, Krystle Trosclair, John Glawe, Zaki Al-Yafeai, Mazen Iqbal, Brenna H. Pearson, Kathryn A. Hamilton, A. Wayne Orr, Edward Glasscock, Christopher G. Kevil, Paari Dominic
Summary: Oxidative stress is a driving factor in the pathogenesis of atrial fibrillation (AF), with hydrogen sulfide (H2S) playing an important role in regulating electrical remodeling and susceptibility to AF. Patients with AF had significantly lower plasma sulfide levels, and those with persistent AF had even lower levels compared to paroxysmal AF patients. Additionally, CSE knockout mice showed decreased atrial sulfide levels, increased atrial superoxide levels, and enhanced propensity for induced persistent AF compared to wild type mice.
Article
Biology
Chowdhury S. Abdullah, Richa Aishwarya, Shafiul Alam, Mahboob Morshed, Naznin Sultana Remex, Sadia Nitu, Gopi K. Kolluru, James Traylor, Sumitra Miriyala, Manikandan Panchatcharam, Brandon Hartman, Judy King, Mohammad Alfrad Nobel Bhuiyan, Sunitha Chandran, Matthew D. Woolard, Xiuping Yu, Nicholas E. Goeders, Paari Dominic, Connie L. Arnold, Karen Stokes, Christopher G. Kevil, A. Wayne Orr, Md. Shenuarin Bhuiyan
COMMUNICATIONS BIOLOGY
(2020)
Review
Genetics & Heredity
Beatriz Maria Veloso Pereira, Yash T. Katakia, Syamantak Majumder, Karina Thieme
Summary: Chronic kidney disease (CKD) is a major public health concern primarily caused by diabetes and/or hypertension, with high prevalence and mortality rates. Despite years of research, the pathogenesis of CKD remains unclear.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Cell Biology
Yash T. Katakia, Niyati P. Thakkar, Sumukh Thakar, Ashima Sakhuja, Raghav Goyal, Harshita Sharma, Rakshita Dave, Ayushi Mandloi, Sayan Basu, Ishan Nigam, Bhanu V. R. Kuncharam, Shibasish Chowdhury, Syamantak Majumder
Summary: The research suggests that dynamic chromatin modifications may trigger inflammatory and apoptotic responses in endothelial cells, and epigenetic reprogramming could potentially enhance outcomes in cardiovascular diseases associated with endothelial inflammation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Paari Dominic, Javaria Ahmad, Ruchi Bhandari, Sibile Pardue, Juan Solorzano, Keerthish Jaisingh, Megan Watts, Steven R. Bailey, A. Wayne Orr, Christopher G. Kevil, Gopi K. Kolluru
Summary: The study observed significantly reduced levels of NO and H2S in COVID-19 patients, with higher levels in deceased patients. Free sulfide levels were found to be highly predictive of COVID-19 infection.
Meeting Abstract
Biochemistry & Molecular Biology
Sibile Pardue, Gopi Kolluru, Xinggui Shen, Eric Kelley, Chris Kevil
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Sumukh Thakar, Yash T. Katakia, Shyam Kumar Ramakrishnan, Niyati Pandya Thakkar, Syamantak Majumder
Summary: The research reveals that intermittent high glucose exposure induces endothelial inflammation, possibly through increased H3K27me3 levels, EZH2 nuclear retention, and inhibition of KLF2 and KLF4 gene expression.
Article
Cell Biology
Niyati Pandya Thakkar, Beatriz Maria Veloso Pereira, Yash T. Katakia, Shyam Kumar Ramakrishnan, Sumukh Thakar, Ashima Sakhuja, Gayathry Rajeev, S. Soorya, Karina Thieme, Syamantak Majumder
Summary: This study identifies the crucial role of histone methylation in hyperglycemia-dependent reprogramming of endothelial cells to undergo mesenchymal transition and indicates that epigenetic pathways contribute to diabetes-associated vascular complications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biology
Yash T. Katakia, Satyadevan Kanduri, Ritobrata Bhattacharyya, Srinandini Ramanathan, Ishan Nigam, Bhanu Vardhan Reddy Kuncharam, Syamantak Majumder
Summary: The angle of blood vessel bifurcation is an important determinant of atherosclerosis and endothelial dysfunction, as it can alter hemodynamics and impact endothelial structure and function.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Jamila H. Siamwala, Jim A. Mossman, Christoph Schorl, Diana Borgas, Pavlo Sakhatskyy, David M. Rand, Qing Lu, Sharon Rounds
Summary: Cigarette smoking increases the risk of acute respiratory distress syndrome (ARDS) and causes emphysema. Smoke-exposed AKR mice were found to be more susceptible to LPS-induced acute lung injury (ALI) than C57BL/6 mice. Therefore, we investigated strain-dependent lung transcriptomic responses to cigarette smoke (CS).
PHYSIOLOGICAL GENOMICS
(2023)
Article
Biology
Jamila H. Siamwala, Francesco S. Pagano, Patrycja M. Dubielecka, Malina J. Ivey, Jose Pedro Guirao-Abad, Alexander Zhao, Sonja Chen, Haley Granston, Jae Yun Jeong, Sharon Rounds, Onur Kanisicak, Sakthivel Sadayappan, Richard J. Gilbert
Summary: Using single-cell mass cytometry, researchers have identified a subpopulation of human cardiac fibroblasts in fibrotic tissue of pulmonary arterial hypertension patients that display features of both mesenchymal and lymphoid origin cells. Induction of IL-1 beta in these fibroblasts results in immune competency and suggests modulation of fibroblast secretome as a potential therapeutic approach for pulmonary arterial hypertension and other inflammation-related fibrotic diseases.
COMMUNICATIONS BIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Javaria Ahmad, Juan Solorzano, Keerthish Jaisingh, Sindhu Thevuthasan, Addison Foster, Megan Watts, Wayne W. Orr, Chris Kevil, Gopi Krishna Kolluru, Paari Dominic
Meeting Abstract
Cardiac & Cardiovascular Systems
Gopi Kolluru, Megan Watts, Zoya Mohammad, Javaria Ahmad, Sindhu Thevuthasan, Parinita Dherange, Sibile Pardue, Christopher Kevil, Paari Dominic
Review
Physiology
Jamila H. Siamwala, Alexander Zhao, Haley Barthel, Francesco S. Pagano, Richard J. Gilbert, Sharon Rounds
PHYSIOLOGICAL REPORTS
(2020)
