Article
Pharmacology & Pharmacy
Jian Chen, Xian Lin, Kangdi Liu, Juan He, Xin Li, Chuchu Zhang, Yongxing Deng, Lianxiang Luo, Cheng Tao, Qingwen Wang
Summary: This study demonstrated that a novel compound CT2-3 inhibits the abnormal functions of RA-fibroblastlike synoviocytes (RA-FLSs) by inducing cell cycle arrest and apoptosis through modulating the PI3K/AKT pathway, offering a potential lead compound for the development of novel anti-RA drugs.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Immunology
Yong Chen, Baojiang Wang, Yanjuan Chen, Qunyan Wu, Wing-Fu Lai, Laiyou Wei, Kutty Selva Nandakumar, Dongzhou Liu
Summary: HAPLN1 plays a role in promoting cell proliferation and pro-inflammatory phenotype in rheumatoid arthritis, contributing to the pathogenesis of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yuan Liu, Peishi Rao, Hongyan Qian, Yesi Shi, Shiju Chen, Jingying Lan, Dan Mu, Rongjuan Chen, Xinwei Zhang, Chaoqiong Deng, Gang Liu, Guixiu Shi
Summary: Fibroblast-like synoviocytes (FLS) are the main cell component in inflamed joints of patients with rheumatoid arthritis (RA) and interact with infiltrating T cells. Under normal conditions, FLS have inhibitory effects on T cells, but in RA, FLS exhibit a proinflammatory phenotype. The signals that control FLS heterogeneity are still unclear.
Article
Cell Biology
Shih-Yao Chen, Jeng-Long Hsieh, Po-Ting Wu, Ai-Li Shiau, Chao-Liang Wu
Summary: This study found that decreased expression of miR-133 is associated with aberrant proliferation and migration of RA FLS. Overexpression of miR-133 reduced cell viability and migration of RA FLS, with decreased levels of FSCN1, EGFR, and MET.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Immunology
Zewen Wu, Dan Ma, Helin Yang, Jinfang Gao, Gailian Zhang, Ke Xu, Liyun Zhang
Summary: Fibroblast-like synoviocytes (FLS) play a crucial role in the pathophysiology of rheumatoid arthritis (RA) and have become the main focus of research. Advances in technology, such as high-throughput sequencing, have made it possible to identify different FLS subsets, allowing for a detailed study of RA pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mei Meng, Zhenggang Yue, Lu Chang, Yanru Liu, Jinhang Hu, Zhongxing Song, Zhishu Tang, Rui Zhou, Changli Wang
Summary: PS VII inhibits the proliferation and induces apoptosis of RA-FLS and MH7A cells by regulating the mitochondrial apoptotic pathway and the JNK and p38 MAPK pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Yirixiati Aihaiti, Xiadiye Tuerhong, Haishi Zheng, YongSong Cai, Mingyi Yang, Peng Xu
Summary: PRDX4 is up-regulated in synovial tissue of RA patients and regulates the tumor cell-like characteristics of RA-FLS through activation of the PI3K/Akt signaling pathway.
CLINICAL IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Luya Pu, Qingyu Meng, Shuai Li, Bin Liu, Fan Li
Summary: Icariin can inhibit the proliferation of FLSs by interfering with the cell cycle process and inducing cell apoptosis, indicating its potential for the treatment of RA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiao-Feng Li, Sha Wu, Qi Yan, Yuan-Yuan Wu, He Chen, Su-Qin Yin, Xin Chen, Hua Wang, Jun Li
Summary: The study reveals that PTEN methylation promotes inflammation and activation in fibroblast-like synoviocytes (FLS) in the pathogenesis of rheumatoid arthritis (RA). Inhibiting methylation can reduce inflammation and alleviate joint swelling, potentially serving as an effective treatment strategy for RA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
M. Vomero, M. Caliste, C. Barbati, M. Speziali, A. I. Celia, F. Ucci, C. Ciancarella, E. Putro, T. Colasanti, G. Buoncuore, E. Corsiero, M. Bombardieri, F. R. Spinelli, F. Ceccarelli, F. Conti, C. Alessandri
Summary: The study demonstrates that tofacitinib has the ability to modulate autophagy in fibroblast-like synoviocytes, contributing to its effectiveness in treating patients with rheumatoid arthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Weihong Xu, Lu Ye, Huaxiang Wu
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with increasing incidence globally. The study revealed that miR-4423-3p is downregulated in RA patients and targets MMP13 to inhibit cell proliferation, migration, and invasion while promoting apoptosis in HFLS-RA cells.
Article
Oncology
Jian Chen, Xian Lin, Juan He, Dandan Liu, Lianhua He, Miaomiao Zhang, Huijie Luan, Yiping Hu, Cheng Tao, Qingwen Wang
Summary: The study found that ATT has potential therapeutic effects on RA by suppressing proliferation, migration, and invasion of RA-FLSs, as well as inducing apoptosis. ATT achieves therapeutic potential for RA by modulating the METTL3/ICAM2/PI3K/AKT/p300 feedback loop.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Ziye Wang, Zhen Zhao, Zhichang Li, Liling Xu, Hongchao Li, Huaqun Zhu, Gong Cheng, Ranran Yao, Wenwen Pei, Ruyu Liang, Renge Liang, Hua Ye, Shan Jiang, Haitao Niu, Xiaolin Sun, Yin Su
Summary: This study reveals the correlation between Tyro3 Protein Tyrosine Kinase (Tyro3TK) expression and the progression of rheumatoid arthritis (RA). Blocking Tyro3TK can reduce the secretion of inflammatory cytokines and matrix metalloproteinases, limit migration and invasiveness of RA fibroblast-like synoviocytes (FLS), and attenuate the differentiation of pathogenic helper T cell subsets mediated by FLS. Additionally, in vivo studies show that Tyro3TK-deficient mice have reduced joint pathology, tempered synovial inflammation, and restored immune cell equilibrium.
CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Yanhua Zuo, Huaheng Xu, Yanxia Li, Zongfang Zhang, Ran Tao, Manxiang Wang
Summary: Synovial samples from RA patients and normal controls were used to isolate FLSs. Increased expression of circ_0007707 was observed in synovial samples from RA patients and FLS-RA cells. Circ_0007707 silencing inhibited cell proliferation, induced cell apoptosis, and decreased cell inflammatory response in FLS-RA cells. Mechanistically, circ_0007707 mediated cell apoptosis and inflammatory response in FLS-RA cells through the miR-27b-3p/PDE3B axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yu Tai, Bei Huang, Pai-pai Guo, Zhen Wang, Zheng-wei Zhou, Man-man Wang, Han-fei Sun, Yong Hu, Sheng-lin Xu, Ling-ling Zhang, Qing-tong Wang, Wei Wei
Summary: Our study demonstrates the impact of TNF-alpha on cAMP homeostasis and the interaction between TNF-alpha and EP4 signaling, revealing the potential role of TRAF2 and GRK2 in the treatment of inflammatory diseases. The findings provide valuable insights into a novel form of cross-talk between cytokine receptors and G protein-coupled receptors, suggesting TRAF2-GRK2 interaction as a potential new drug target.
ACTA PHARMACOLOGICA SINICA
(2022)