Article
Food Science & Technology
Zhou Si, Haoxiang Chen, Chensi Gu, Tingting Wang, Ziluan Fan
Summary: Schisandra chinensis extract (SCE) has significant anti-fatigue effects in mice by prolonging swimming time, increasing levels of hepatic and muscular glycogen, reducing levels of lactic acid, blood urea nitrogen, and malondialdehyde, enhancing activities of antioxidant enzymes, and activating the AMPK/PGC-1 alpha signaling pathway.
Article
Plant Sciences
Jing Zhao, Kaixin Ding, Manting Hou, Yuanhua Li, Xiaorong Hou, Wenzhang Dai, Zhiyong Li, Jun Zhao, Wenlong Liu, Zhaofang Bai
Summary: This study demonstrated that Schisandra chinensis essential oil has protective effects against acetaminophen-induced liver injury in mice, suggesting its potential as a therapeutic option for liver diseases.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tingxu Yan, Qianqian Mao, Xiaozhuo Zhang, Bo Wu, Kaishun Bi, Bosai He, Ying Jia
Summary: The study revealed that Schisandra chinensis protects against dopaminergic neurodegeneration in 6-OHDA-induced Parkinson's disease mice by modulating the BDNF/Nrf2/NF-kappa B signaling pathway to suppress oxidative stress, neuroinflammation, and apoptosis.
Article
Medicine, Research & Experimental
Xiaowen Shi, Bingjiang Han, Bin Zhang, Zhenliang Chu, Xueping Zhang, Qin Lu, Jibo Han
Summary: The study demonstrated that the antioxidative effects of SCP in attenuating oxidative stress were mediated through the regulation of the TXNIP/Trx-1 pathway, potentially making TXNIP a therapeutic target for treating cardiac hypertrophy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jun Fu, Jixun Li, Yuzhen Sun, Shu Liu, Fengrui Song, Zhongying Liu
Summary: This study investigated the therapeutic effects and mechanism of action of the polysaccharide SCP2 from Schisandra chinensis on AD rats. The results showed that SCP2 improved cognitive dysfunction, oxidative damage, and A beta deposition in the hippocampus. Metabolomics analysis revealed that SCP2 reversed the metabolic profile disorder in AD rats, identifying key metabolites involved in fatty acid metabolism. These findings provide new insights into the potential of SCP2 for treating AD and lay a foundation for future structure-activity studies.
Article
Plant Sciences
Ting-Yan Qiang, Jiu-Shi Liu, Yu-Qing Dong, Xin-Lu Mu, Yu Chen, Hong-Mei Luo, Ben-Gang Zhang, Hai-Tao Liu
Summary: This study identified an enzyme with catalytic activity from the Schisandraceae family and found the first functionally characterized enzyme, laying the foundation for further research on the complete biosynthetic pathway of dibenzocyclooctadiene lignans.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Dalia M. Kopustinskiene, Jurga Bernatoniene
Summary: Schisandra chinensis fruits, their extracts, and bioactive compounds have potent antioxidant and mitoprotective effects, exerting anti-inflammatory, antiviral, anticancer, and anti-aging properties. The polyphenolic compounds in S. chinensis are responsible for its antioxidant activities, which play a significant role in protecting cells under normal and pathological conditions.
Article
Marine & Freshwater Biology
Jana Valickova, Stepan Zezulka, Eliska Marsalkova, Josef Kotlik, Blahoslav Marsalek, Radka Opatrilova
Summary: Schisandra chinensis is a potential plant for production of nutrient supplements, but it can have allelopathic effects on other plants. The eco-toxicological properties of S. chinensis have not been verified in European ecosystems. In this study, Lemna minor was used as a model aquatic plant to test the impact of S. chinensis extract on the aquatic environment. The extract caused significant limitations in duckweed growth and photosynthetic performance at higher concentrations, and extreme toxicity at the highest concentration of 45 mg/L.
AQUATIC TOXICOLOGY
(2023)
Article
Chemistry, Medicinal
Jun-nan Hu, Yi-ming Wang, Hao Zhang, Hui-ping Li, Zi Wang, Mei Han, Shen Ren, Shan Tang, Shuang Jiang, Wei Li
Summary: The study found that Scheme B has a protective effect on cisplatin-induced rat intestinal crypt epithelial cell injury. It achieves this by reducing oxidative stress, inhibiting cell apoptosis and inflammation, and repairing intestinal barrier function.
PHYTOTHERAPY RESEARCH
(2023)
Article
Plant Sciences
Woo Sung Park, Kyung Ah Koo, Ji-Yeong Bae, Hye-Jin Kim, Dong-Min Kang, Ji-Min Kwon, Seung-Mann Paek, Mi Kyeong Lee, Chul Young Kim, Mi-Jeong Ahn
Summary: A study analyzed the content of seven lignans in Schisandra chinensis fruit using HPLC-DAD, revealing that seeds had the highest content. The addition of oligosaccharide/white sugar to fermented beverages significantly increased lignan content.
Article
Agriculture, Multidisciplinary
Xiaorong Guo, Lei Liu, Wenqi Zhao, Xingyun Li, Xiaoli Wang, Anhong Ning, Jing Cao, Wei Zhang, Liang Cao, Mintao Zhong
Summary: Schisandra chinensis (Turcz.) Baill polysaccharide has a protective effect against ulcerative colitis in mice by reducing disease activity, improving tissue damage, enhancing colonic mucosal barrier function, inhibiting NF-kappa B pathway activation, and modulating gut microbiota.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Plant Sciences
Ke Yang, Jing Qiu, Zecheng Huang, Ziwei Yu, Wenjun Wang, Huiling Hu, Yu You
Summary: Schisandra chinensis and Schisandra sphenanthera, known as bei-wuweizi and nan-wuweizi in Chinese respectively, are highly similar plants with traditional uses in Chinese medicine for treating various conditions. They have similar chemical compositions and pharmacological activities, with potential drug interactions due to their inhibitory effects on CYP3A and P-gp. Further research is needed to explore their traditional uses and differences for clinical applications.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zi Qi Peng, Yan Liu, Si Yi Wang, Yi Kai Jiang, Xiao Mao Li, Xiao Hui Rong, Ye Sun, Juan Pan, Wei Guan, Adnan Mohammed Algradi, Hai Xue Kuang, Bing You Yang
Summary: One new phenylpropanoid schineolignin D, one new sesquiterpene, one new quinic acid compound, and seven known compounds were isolated from the roots of Schisandra chinensis. NMR spectroscopic experiments confirmed the chemical structures of all compounds. Some of the compounds showed significant neuroprotective effects against H2O2-induced cell toxicity.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Applied
Yong-Xin Huang, Jun Liang, Jun-Hong Chai, Hai-Xue Kuang, Yong-Gang Xia
Summary: A novel galacturonoglucan, SCP-1, is isolated and characterized from Schisandra chinensis fruits. The structure of SCP-1 is systematically investigated using various analytical techniques and is described as a complex repeating unit with specific monosaccharide compositions and branching points. In vitro anti-tumor assays demonstrate the potential of SCP-1 in inhibiting human HepG2 cancer cell growth.
CARBOHYDRATE POLYMERS
(2023)
Article
Agronomy
Beung Sung Kim, Jong Soo Kim, Young Jin Seo, Tae Young Oh, Jeong-Dong Lee
Summary: This study collected 96 accessions of Schisandra chinensis in South Korea to evaluate their phenotypes using principal component analysis and cluster analysis. Significant variations among the measured phenotypic traits were observed. The results provide valuable information for systematic characterization of species germplasm collections and tools for further research.
