Article
Biotechnology & Applied Microbiology
Huiru Fu, Yongjing Li, Jing Tian, Ben Yang, Yin Li, Qi Li, Shikai Liu
Summary: Rising ocean temperature poses a significant threat to marine organisms' adaptation and survival, leading to ecological impacts and economic losses. This study revealed a new regulatory mechanism mediated by hypoxia-inducible factor-1a (HIF-1a) in Pacific oysters (Crassostrea gigas) in response to heat stress. HIF-1a and HIF-1a-like5 were found to be highly induced under heat stress and played critical roles in the heat shock response (HSR) by upregulating the expression of heat shock proteins (HSP). Knocking down of HIF-1a inhibited the expression of heat shock factor 1 (HSF1) and HSP70 genes, leading to decreased survival of C. gigas under heat stress. The involvement of HIF-1a/HSF1/HSP70 pathway in the oyster's response to heat stress provides insights into the adaptive mechanisms of bivalves to ocean warming.
MARINE BIOTECHNOLOGY
(2023)
Article
Biology
Lori A. Manzon, Megan A. Zak, Matthew Agee, Douglas R. Boreham, Joanna Y. Wilson, Christopher M. Somers, Richard G. Manzon
Summary: The study examined the thermal acclimation and heat shock response of lake whitefish in different temperature environments. The findings showed that acclimation to 18 degrees C increased basal expression of heat shock proteins, while 6 degrees C acclimation had no effect. Fish in all groups were capable of eliciting a robust heat shock response following acute heat shock. These results indicate that environmental temperature influences both basal heat shock protein levels and the heat shock response in lake whitefish.
JOURNAL OF THERMAL BIOLOGY
(2022)
Review
Plant Sciences
M. Ashraf
Summary: Improving thermotolerance in plants requires precise selection criteria based on physiological, biochemical, and molecular processes, rather than solely focusing on yield attributes. Understanding the specific genes involved in stress tolerance is crucial for successful breeding programs and gene editing using advanced techniques.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Physiology
Elena Fanelli, Alberto Troccoli, Eustachio Tarasco, Francesca De Luca
Summary: Research has shown the key role of Hb-hsp90-1 in adapting to temperature changes and the host environment, with its silencing resulting in prolonged infection process and reduced reproductive potential.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Yudong Quan, Zhenying Wang, Hongyi Wei, Kanglai He
Summary: The relationship between heat acclimation and the expression of specific HSPs plays a critical role in insect adaptation and evolution. Extreme thermal stress induces quick onset of HSP70 or HSP90 transcription, potentially aiding in adaptation to drastic temperature variations. Furthermore, the thermal tolerance of larvae is significantly enhanced after 6 hours of recovery, possibly regulated by HSP70.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Neurosciences
Igor F. F. Belenichev, Olena G. G. Aliyeva, Olena O. O. Popazova, Nina V. V. Bukhtiyarova
Summary: This analytical review summarizes literature data and our own research on HSP70-dependent mechanisms of neuroprotection and discusses potential pharmacological agents that can influence HSP70 expression to improve neurological outcomes and effective therapy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Environmental Sciences
Wenjing Liu, Lin Huang, Xin Liang, Lijuan Liu, Chengliang Sun, Xianyong Lin
Summary: The study found that exposing wheat seedlings to short-term high temperature significantly alleviated aluminum-induced root growth inhibition, while maintaining lower levels of lipid peroxidation and higher cell viability. Furthermore, the high temperature treatment increased the levels of reduced ascorbate and glutathione in wheat roots, as well as the activities of cycle-allied enzymes.
Article
Biochemistry & Molecular Biology
Nobutoshi Yamaguchi, Toshiro Ito
Summary: Exposure to moderately high temperatures allows plants to acquire thermotolerance by removing H3K27me3 and maintaining H3K4me3 levels, enabling them to 'remember' the heat experience. JMJs mediate the balance between H3K27me3 and H3K4me3 at the HSP21 locus during heat acclimation.
Review
Cardiac & Cardiovascular Systems
Shruti Ghai, Alex Young, Kuo-Hui Su
Summary: Atherosclerosis is a major risk factor for cardiovascular diseases, and hypercholesterolemia is involved in its initiation. Heat shock factor 1 (HSF1) plays a critical role in controlling atherosclerosis by regulating heat shock proteins (HSPs) and lipid metabolism. Recent research shows that HSF1 directly interacts with and inhibits AMP-activated protein kinase (AMPK), promoting lipogenesis and cholesterol synthesis. This review highlights the roles of HSF1 and HSPs in critical metabolic pathways of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Environmental Sciences
Yu-Cheng Wang, Ya-Wen Chang, Jing Bai, Xiao-Xiang Zhang, Junaid Iqbal, Ming-Xing Lu, Wei-Rong Gong, Yu-Zhou Du
Summary: The leafminer fly Liriomyza trifolii exhibits adaptive cross-tolerance to high temperature and abamectin, which can ultimately reduce the overuse of pesticides.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Agronomy
Chuanbei Tian, Yaying Li, Yixia Wu, Wenqiang Chu, Huai Liu
Summary: In fluctuating climatic environments, heat acclimation in predatory mites is a superior adaptation strategy for effective agricultural pest management. The sustained accumulation of HSP70 proteins results in predatory mites with thermotolerance advantage, promoting their biological control function to pests. The divergent constitutive regulation of HSP70 to a thermal environment allows predators to adapt flexibly to extreme stress.
PEST MANAGEMENT SCIENCE
(2021)
Article
Cell & Tissue Engineering
Ju-Fang Liu, Po-Chun Chen, Thai-Yen Ling, Chun-Han Hou
Summary: This study demonstrates that heat shock induces the expression of HSPs in hPDMCs through the activation of ROS, p38 MAPK, Akt signaling, and HSF1, which plays a protective role.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Ariadni Androvitsanea, Kostas Stylianou, Eleni Drosataki, Ioannis Petrakis
Summary: Research has shown that heat-shock proteins can have varying effects on the immune system, either triggering immune responses or alleviating them, which is important for studying and treating autoimmune diseases.
Article
Biochemistry & Molecular Biology
Faith O. Alele, John R. Otto, Bunmi S. Malau-Aduli, Aduli E. O. Malau-Aduli
Summary: This pilot study found an association between a genetic variant in the HSPA1B gene at the g.31829044 locus and heat tolerance among Australian Defence Force members with a history of exertional heat stroke.
Article
Biochemistry & Molecular Biology
Gabriela Antonio-Andres, Gustavo U. Martinez-Ruiz, Mario Morales-Martinez, Elva Jimenez-Hernandez, Estefany Martinez-Torres, Tania V. Lopez-Perez, Laura A. Estrada-Abreo, Genaro Patino-Lopez, Sergio Juarez-Mendez, Victor M. Davila-Borja, Sara Huerta-Yepez
Summary: This study reveals that HIF-1 alpha can transcriptionally regulate YY1, and the expression of HIF-1 alpha positively correlates with YY1 in leukemia patients, suggesting that they may serve as therapeutic targets or biomarkers for ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Rafiad Islam, Kentaro Matsuzaki, Eri Sumiyoshi, Md Emon Hossain, Michio Hashimoto, Masanori Katakura, Naotoshi Sugimoto, Osamu Shido
Article
Biochemistry & Molecular Biology
Shahdat Hossain, Jakir Hussain, Sujan Bhowmick, Marzan Sarkar, Mafroz Basunia, Abdullah Al Mamun, Yoko Tanabe, Kentaro Matsuzaki, Michio Hashimoto, Osamu Shido
BIOLOGICAL TRACE ELEMENT RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Kentaro Matsuzaki, Naotoshi Sugimoto, Rafiad Islam, Md Emon Hossain, Eri Sumiyoshi, Masanori Katakura, Osamu Shido
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Michio Hashimoto, Yoko Tanabe, Shandat Hossain, Kentaro Matsuzaki, Miho Ohno, Setsushi Kato, Masanori Katakura, Osamu Shido
Article
Food Science & Technology
Michio Hashimoto, Kentaro Matsuzaki, Setsushi Kato, Shahdat Hossain, Miho Ohno, Osamu Shido
Review
Food Science & Technology
Michio Hashimoto, Shahdat Hossain, Kentaro Matsuzaki, Osamu Shido, Katsumi Yoshino
Summary: Although brown rice has higher nutrient levels than white rice, its consumption is still not popular due to taste and cooking time. However, non-thermal ultra-high hydrostatic pressure treatment can improve the characteristics of brown rice, making it more palatable and nutritious. This treatment also has the potential to treat certain diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Nutrition & Dietetics
Kentaro Matsuzaki, Yasushi Ohizumi
Summary: The number of patients with central nervous system disorders is increasing, with current pharmacologic options for prevention and treatment being largely unsuccessful. Development of drugs or functional foods to prevent neurodegenerative disorders is highly anticipated. PMFs derived from citrus fruit have shown promise in preventing neurodegenerative and neurological disorders by exerting positive effects on pathological features such as oxidative stress, neuroinflammation, and synaptic dysfunction.
Article
Oncology
Naotoshi Sugimoto, Masanori Katakura, Kentaro Matsuzaki, Mayumi Miyamoto, Eri Sumiyoshi, Taizo Wada, Akihiro Yachie, Hiroyuki Nakamura, Osamu Shido
Summary: The active components in ginger root can modify cell functions, including promoting cell migration and enhancing tolerance against heat shock in mouse fibroblast cells.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Abdullah Al Mamun, Kentaro Matsuzaki, Rafiad Islam, Shahdat Hossain, Md Emon Hossain, Masanori Katakura, Hiroyuki Arai, Osamu Shido, Michio Hashimoto
Summary: Thymoquinone (TQ), an active component of Nigella sativa Linn. seeds, has been found to promote proliferation and neural differentiation of neural stem/progenitor cells. Chronic administration of TQ in adult rats enhances neurogenesis in the hippocampus and improves avoidance-related learning ability, possibly through the CREB/BDNF signaling pathways.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Michio Hashimoto, Kentaro Matsuzaki, Koji Maruyama, Shahdat Hossain, Eri Sumiyoshi, Harumi Wakatsuki, Setsushi Kato, Miho Ohno, Yoko Tanabe, Yoko Kuroda, Shuhei Yamaguchi, Koji Kajima, Yasushi Ohizumi, Osamu Shido
Summary: Perilla seed oil supplements, especially when combined with nobiletin-rich air-dried immature ponkan powder, can improve cognitive function in healthy elderly individuals by increasing omega-3 fatty acid levels in red blood cells. This intervention also enhanced serum brain-derived neurotropic factor (BDNF) levels and biological antioxidant potential.
Review
Nutrition & Dietetics
Kentaro Matsuzaki, Akira Nakajima, Yuanqiang Guo, Yasushi Ohizumi
Summary: As life expectancy increases, age-associated diseases such as Alzheimer's disease become a major health problem. However, research has shown that compounds found in citrus fruits have neuroprotective effects and can improve cognitive function and reduce the risk of related diseases.
Article
Chemistry, Applied
Takashi Ichinose, Kentaro Matsuzaki, Masaharu Kato, Yoko Tanabe, Nobuhiko Tachibana, Miwako Morikawa, Setsushi Kato, Shuzo Ohata, Miho Ohno, Harumi Wakatsuki, Shahdat Hossain, Osamu Shido, Michio Hashimoto
Summary: The study found that long-term daily intake of a DHA-enriched milk beverage can increase levels of DHA and EPA fatty acids in erythrocyte membranes, prevent cognitive decline, and decrease serum bone resorption marker levels.
JOURNAL OF OLEO SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Eri Sumiyoshi, Michio Hashimoto, Shahdat Hossain, Kentaro Matsuzaki, Rafiad Islam, Yoko Tanabe, Koji Maruyama, Koji Kajima, Hiroyuki Arai, Yasushi Ohizumi, Osamu Shido
Summary: Research shows that AC extract can improve learning and memory in elderly mice without causing noticeable side effects in the body.
Article
Food Science & Technology
Takashi Ichinose, Masaharu Kato, Kentaro Matsuzaki, Yoko Tanabe, Nobuhiko Tachibana, Miwako Morikawa, Setsushi Kato, Shuuzo Ohata, Miho Ohno, Harumi Wakatsuki, Shahdat Hossain, Osamu Shido, Michio Hashimoto
JOURNAL OF FUNCTIONAL FOODS
(2020)