Apoptosis Induced by Benzyl Isothiocyanate in Gefitinib-Resistant Lung Cancer Cells is Associated with Akt/MAPK Pathways and Generation of Reactive Oxygen Species

Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates

(2011) Huiqin Yan et al.   BRITISH JOURNAL OF NUTRITION

Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylases

(2011) V. S. Thakur et al.   CARCINOGENESIS

 -Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth

(2011) J. J. Johnson et al.   CARCINOGENESIS

Activation of Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Mediates Acquired Resistance to Sorafenib in Hepatocellular Carcinoma Cells

(2011) K.-F. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Treatment of Non–Small-Cell Lung Cancer with Erlotinib or Gefitinib

(2011) Vince D. Cataldo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development of Resistance towards Artesunate in MDA-MB-231 Human Breast Cancer Cells

(2011) Beatrice Bachmeier et al.   PLoS One

Acetonic Extract of Buxus sempervirens Induces Cell Cycle Arrest, Apoptosis and Autophagy in Breast Cancer Cells

(2011) Ouardia Ait-Mohamed et al.   PLoS One

Benzyl Isothiocyanate Suppresses Pancreatic Tumor Angiogenesis and Invasion by Inhibiting HIF-α/VEGF/Rho-GTPases: Pivotal Role of STAT-3

(2011) Srinivas Reddy Boreddy et al.   PLoS One

Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound  -phenylethyl isothiocyanate

(2010) Y. Hu et al.   BLOOD

Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells

(2010) Xiang Wu et al.   BMC CANCER

Targeting the p38 MAPK Pathway Inhibits Irinotecan Resistance in Colon Adenocarcinoma

(2010) S. Paillas et al.   CANCER RESEARCH

Inhibiting the PI3K/Akt pathway reversed progestin resistance in endometrial cancer

(2010) Chao Gu et al.   CANCER SCIENCE

Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells

(2010) L. Mi et al.   CARCINOGENESIS

Sensitization of Non-small Cell Lung Cancer Cells to Cisplatin by Naturally Occurring Isothiocyanates

(2010) Anthony J. Di Pasqua et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Integrated Quantitative Analysis of the Phosphoproteome and Transcriptome in Tamoxifen-resistant Breast Cancer

(2010) Masaaki Oyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenethyl Isothiocyanate Inhibits Oxidative Phosphorylation to Trigger Reactive Oxygen Species-mediated Death of Human Prostate Cancer Cells

(2010) Dong Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activated Phosphoinositide 3-Kinase/AKT Signaling Confers Resistance to Trastuzumab but not Lapatinib

(2010) N. A. O'Brien et al.   MOLECULAR CANCER THERAPEUTICS

Understanding resistance to EGFR inhibitors—impact on future treatment strategies

(2010) Deric L. Wheeler et al.   Nature Reviews Clinical Oncology

Phenethyl Isothiocyanate Sensitizes Androgen-Independent Human Prostate Cancer Cells to Docetaxel-Induced Apoptosis In Vitro and In Vivo

(2010) Dong Xiao et al.   PHARMACEUTICAL RESEARCH

Are isothiocyanates potential anti-cancer drugs?

(2009) Xiang Wu et al.   ACTA PHARMACOLOGICA SINICA

Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities

(2009) Georg T. Wondrak   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2

(2009) M. Gupta et al.   BLOOD

PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR

(2009) M. L. Sos et al.   CANCER RESEARCH

Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells

(2009) Ravi P. Sahu et al.   CARCINOGENESIS

BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4

(2009) Momoko Suzuki et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways

(2009) Sandra E. Ghayad et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

(2008) D. Trachootham et al.   BLOOD

Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells

(2008) Xianling Guo et al.   BMC CANCER

Lower Level of MAPK Expression Is Associated with Anthracycline Resistance and Decreased Survival in Patients with Hormone Receptor Negative Breast Cancer

(2008) Duygu Derin et al.   CANCER INVESTIGATION

Induction of apoptosis by phenethyl isothiocyanate in cells overexpressing Bcl-XL

(2008) Sarah L. Cuddihy et al.   CANCER LETTERS

Covalent Binding to Tubulin by Isothiocyanates

(2008) Lixin Mi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism

(2008) H Zhang et al.   LEUKEMIA