Review
Cell Biology
Maria-Alexandra Papadimitriou, Konstantina Panoutsopoulou, Katerina-Marina Pilala, Andreas Scorilas, Margaritis Avgeris
Summary: Methylation of DNA/RNA and proteins is crucial for cellular homeostasis and development, and disrupted methylation imprinting is strongly associated with human pathologies, especially cancer. Recent evidence has shown that miRNAs play a significant role in regulating cellular methylation profiles during cancer onset and progression. Epi-miRNAs are a novel subclass of miRNAs that have potential clinical utility in cancer diagnostics and personalized therapeutics.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Review
Chemistry, Medicinal
Carmen Nunez-Carro, Margarita Blanco-Blanco, Karla Mariuxi Villagran-Andrade, Francisco J. Blanco, Maria C. de Andres
Summary: In this study, we reviewed the current understanding of epigenetic mechanisms in relation to the pathogenesis of OA, particularly in articular cartilage. Evidence suggests that dysregulation of crucial cartilage molecules is a result of aberrant epigenetic regulatory mechanisms, which contribute to the development and progression of OA. This provides an opportunity to explore new therapeutic targets and novel biomarkers for the disease.
Review
Food Science & Technology
Tianyi Guo, Otobong Donald Akan, Feijun Luo, Qinlu Lin
Summary: Polysaccharides, derived from natural products, are valued for their effective health-related activities. Recent studies have shown that polysaccharides exert biological effects through epigenetic mechanisms, participating in the regulation of immunity, inflammation, metabolism, and antioxidant damage. This review comprehensively summarizes and discusses the latest advances in the biological functions of dietary polysaccharides via epigenetic regulations.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Immunology
Ubaid Ur Rehman, Dawood Ghafoor, Asad Ullah, Riaz Ahmad, Sumaira Hanif
Summary: This review examines the role of epigenetics in regulating virus infection cycles and gene expression, and explores the potential treatment options based on this understanding.
MICROBIAL PATHOGENESIS
(2023)
Review
Endocrinology & Metabolism
Feng-Yao Wu, Rui-Xing Yin
Summary: Obesity is a major global public health problem, and epigenetics has gained increasing interest as a potential regulator of gene-environment interactions in its development. Rapid advancements in epigenetic research methods have led to the discovery of candidate genes and biological markers, improving our understanding of the complex etiology of obesity and offering possibilities for targeted prevention and treatment strategies.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Review
Biochemistry & Molecular Biology
Matea Nikolac Perkovic, Alja Videtic Paska, Marcela Konjevod, Katarina Kouter, Dubravka Svob Strac, Gordana Nedic Erjavec, Nela Pivac
Summary: Validated biomarkers for accurately diagnosing Alzheimer's disease (AD) are currently lacking, but epigenetic modifications have been identified as important factors in the pathogenesis of AD. DNA methylation, hydroxymethylation, histone modifications, and non-coding RNA regulation play critical roles in the development of AD, while mitochondrial DNA may serve as a potential biomarker for AD.
Review
Oncology
Weiwei Xie, Huizhen Sun, Xiaoduan Li, Feikai Lin, Ziliang Wang, Xipeng Wang
Summary: Ovarian cancer is associated with activation of oncogenes and inactivation of tumor suppressor genes, with epigenetic processes playing a key role in tumorigenesis. MicroRNA and long non-coding RNA are promising molecular markers for precision medicine in OC. Clinical application of epigenetic approaches is currently limited by hurdles such as heterogeneity of OC and insufficient sample sizes, but holds promise for future clinical investigation into diagnosis, treatment, and prognosis.
CANCER CELL INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Jing Xu, Hao-ming Xu, Mei-feng Yang, Yu-jie Liang, Quan-zhou Peng, Yuan Zhang, Cheng-mei Tian, Li-sheng Wang, Jun Yao, Yu-qiang Nie, De-feng Li
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the colon mucosa, involving environmental factors, genetics, intestinal microbiota, and the immune system. Recent evidence suggests that abnormal epigenetic changes play a crucial role in the development of IBD, affecting functions such as intestinal epithelium homeostasis and immune cell regulation. Understanding epigenetic modifications in IBD not only provides new insights into the disease's pathophysiology, but also offers potential biomarkers and therapeutic targets for intervention in IBD patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Tian-En Si, Zhixiao Li, Jingjing Zhang, Songxue Su, Yupeng Liu, Shiyue Chen, Guang-Hua Peng, Jing Cao, Weidong Zang
Summary: Retinal degenerative diseases, which cause neuronal death and vision loss, can be treated by reprogramming Muller glia into stem or progenitor cells to regenerate the retina. Epigenetic mechanisms, such as DNA methylation and histone modification, play a crucial role in the reprogramming process. Understanding these mechanisms is important for developing Muller glial reprogramming therapy for retinal degenerative diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ma'mon M. Hatmal, Mohammad A. I. Al-Hatamleh, Amin N. Olaimat, Walhan Alshaer, Hanan Hasan, Khaled A. Albakri, Enas Alkhafaji, Nada N. Issa, Murad A. Al-Holy, Salim M. Abderrahman, Atiyeh M. Abdallah, Rohimah Mohamud
Summary: Human breast milk contains not only nutritional components but also abundant microRNAs, which can impact epigenetic mechanisms and regulate immune and physiological functions. Studying the microRNA composition of human breast milk is important for improving nutrition during pregnancy and infancy and preventing future diseases.
Review
Genetics & Heredity
Jinkun Xia, Wangsen Cao
Summary: Studies show that epigenetic modifications affect the Klotho gene in renal diseases, impacting disease progression. Lowered Klotho levels worsen the condition, but beneficial changes can be made through epigenetic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Jiaxin Liu, Jia-nan Li, Hongyu Wu, Panpan Liu
Summary: Epigenetic regulation plays a crucial role in lymphoma development and is closely associated with various malignancies. Understanding these epigenetic mechanisms can guide the development of clinical treatments.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Young-Su Yi
Summary: Inflammasome, activated in response to infection and damage, triggers inflammatory responses, while methylation, a critical biological process, modulates gene expression. The functional relationship between inflammasome regulation and methylation may play a key role in inflammatory responses and disease development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Dipanwita Das, Nandini Karthik, Reshma Taneja
Summary: Inflammation is a crucial immune response against infection and tissue damage, but chronic inflammation is linked to cancer development. Immune cells produce inflammatory mediators to facilitate tumor growth, while aberrant expression of inflammatory factors by tumor cells recruits immune cells for mutual crosstalk, creating a conducive environment for tumor growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Theresa D. Ahrens, Sylvia Timme, Jens Hoeppner, Jenny Ostendorp, Sina Hembach, Marie Follo, Ulrich T. Hopt, Martin Werner, Hauke Busch, Melanie Boerries, Silke Lassmann
Article
Medicine, Research & Experimental
Theresa D. Ahrens, Sylvia Timme, Jenny Ostendorp, Lioudmilla Bogatyreva, Jens Hoeppner, Ulrich T. Hopt, Dieter Hauschke, Martin Werner, Silke Lassmann
LABORATORY INVESTIGATION
(2016)
Review
Cell Biology
Theresa D. Ahrens, Lisa Lutz, Silke Lassmann, Martin Werner
Article
Oncology
Kathrin Enderle-Ammour, Moritz Bader, Theresa Dorothee Ahrens, Kai Franke, Sylvia Timme, Agnes Csanadi, Jens Hoeppner, Birte Kulemann, Jochen Maurer, Philip Reiss, Oliver Schilling, Tobias Keck, Thomas Brabletz, Elmar Stickeler, Martin Werner, Ulrich Friedrich Wellner, Peter Bronsert
Article
Biochemistry & Molecular Biology
Stefan Tholen, Martin L. Biniossek, Martina Gansz, Theresa D. Ahrens, Manuel Schlimpert, Jayachandran N. Kizhakkedathu, Thomas Reinheckel, Oliver Schilling
CELLULAR AND MOLECULAR LIFE SCIENCES
(2014)
Article
Multidisciplinary Sciences
Alexander Krohn, Theresa Ahrens, Arzu Yalcin, Till Ploenes, Julius Wehrle, Sanaz Taromi, Stefan Wollner, Marie Follo, Thomas Brabletz, Sendurai A. Mani, Rainer Claus, Bjoern Hackanson, Meike Burger
Article
Oncology
Lisa Lutz, Ingrid Coutino Fitzner, Theresa Ahrens, Anna-Lena Geissler, Frank Makowiec, Ulrich T. Hopt, Lioudmila Bogatyreva, Dieter Hauschke, Martin Werner, Silke Lassmann
AMERICAN JOURNAL OF CANCER RESEARCH
(2016)
