Glaucoma and optic nerve repair

Under Pressure: Cellular and Molecular Responses During Glaucoma, a Common Neurodegeneration with Axonopathy

(2012) Robert W. Nickells et al.   Annual Review of Neuroscience

Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation

(2012) Marco Leibinger et al.   NEUROBIOLOGY OF DISEASE

Glaucoma 2.0: Neuroprotection, Neuroregeneration, Neuroenhancement

(2012) Elma E. Chang et al.   OPHTHALMOLOGY

Promoting optic nerve regeneration

(2012) Dietmar Fischer et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma

(2011) Glyn Chidlow et al.   ACTA NEUROPATHOLOGICA

Latanoprost Promotes Neurite Outgrowth in Differentiated RGC-5 Cells via the PI3K-Akt-mTOR Signaling Pathway

(2011) Jun Zheng et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo

(2011) Lars Tönges et al.   JOURNAL OF NEUROCHEMISTRY

Taxol Facilitates Axon Regeneration in the Mature CNS

(2011) V. Sengottuvel et al.   JOURNAL OF NEUROSCIENCE

Post-Injury Delivery of rAAV2-CNTF Combined with Short-Term Pharmacotherapy Is Neuroprotective and Promotes Extensive Axonal Regeneration after Optic Nerve Trauma

(2011) Mats Hellström et al.   JOURNAL OF NEUROTRAUMA

Glaucoma

(2011) Harry A Quigley   LANCET

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

(2011) Fang Sun et al.   NATURE

Expression of PirB Protein in Intact and Injured Optic Nerve and Retina of Mice

(2011) Xiaofeng Cai et al.   NEUROCHEMICAL RESEARCH

Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury

(2011) F. Hellal et al.   SCIENCE

A Single Nucleotide Polymorphism in the Bax Gene Promoter Affects Transcription and Influences Retinal Ganglion Cell Death

(2010) Sheila J Semaan et al.   ASN Neuro

A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma

(2010) Claude F. Burgoyne   EXPERIMENTAL EYE RESEARCH

Metabolic Vulnerability Disposes Retinal Ganglion Cell Axons to Dysfunction in a Model of Glaucomatous Degeneration

(2010) S. Baltan et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial optic neuropathies – Disease mechanisms and therapeutic strategies

(2010) Patrick Yu-Wai-Man et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Early cellular signaling responses to axonal injury

(2009) Thomas J Lukas et al.   Cell Communication and Signaling

GM-CSF regulates the ERK1/2 pathways and protects injured retinal ganglion cells from induced death

(2009) Maurice Schallenberg et al.   EXPERIMENTAL EYE RESEARCH

Ocular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration

(2009) Manuel Salinas-Navarro et al.   EXPERIMENTAL EYE RESEARCH

Electrical activity enhances neuronal survival and regeneration

(2009) Raul G Corredor et al.   Journal of Neural Engineering

Neuroprotective and Axon Growth-Promoting Effects following Inflammatory Stimulation on Mature Retinal Ganglion Cells in Mice Depend on Ciliary Neurotrophic Factor and Leukemia Inhibitory Factor

(2009) M. Leibinger et al.   JOURNAL OF NEUROSCIENCE

ROCK inhibition promotes adult retinal ganglion cell neurite outgrowth only in the presence of growth promoting factors

(2009) Zubair Ahmed et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Cytokine-induced SOCS expression is inhibited by cAMP analogue: Impact on regeneration in injured retina

(2009) Kevin K. Park et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF

(2009) Adrienne Müller et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Microtubule assembly, organization and dynamics in axons and dendrites

(2009) Cecilia Conde et al.   NATURE REVIEWS NEUROSCIENCE

Optic nerve and vitreal inflammation are both RGC neuroprotective but only the latter is RGC axogenic

(2009) Zubair Ahmed et al.   NEUROBIOLOGY OF DISEASE

SOCS3 Deletion Promotes Optic Nerve Regeneration In Vivo

(2009) Patrice D. Smith et al.   NEURON

Axonal regeneration of optic nerve after crush in Nogo66 receptor knockout mice

(2009) Ying Su et al.   NEUROSCIENCE LETTERS

CNTF, a key factor mediating the beneficial effects of inflammatory reactions in the eye

(2008) D. Fischer   BRAIN

Retinal tau pathology in human glaucomas

(2008) Neeru Gupta et al.   CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE

Nerve injury signaling

(2008) Namiko Abe et al.   CURRENT OPINION IN NEUROBIOLOGY

Retinal Ganglion Cells Downregulate Gene Expression and Lose Their Axons within the Optic Nerve Head in a Mouse Glaucoma Model

(2008) I. Soto et al.   JOURNAL OF NEUROSCIENCE

Progressive Ganglion Cell Degeneration Precedes Neuronal Loss in a Mouse Model of Glaucoma

(2008) B. P. Buckingham et al.   JOURNAL OF NEUROSCIENCE

Effects of optic nerve injury, glaucoma, and neuroprotection on the survival, structure, and function of ganglion cells in the mammalian retina

(2008) A. J. Weber et al.   JOURNAL OF PHYSIOLOGY-LONDON

PirB is a Functional Receptor for Myelin Inhibitors of Axonal Regeneration

(2008) J. K. Atwal et al.   SCIENCE

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE

Crystallins of the β/γ-superfamily mimic the effects of lens injury and promote axon regeneration

(2007) Dietmar Fischer et al.   MOLECULAR AND CELLULAR NEUROSCIENCE