Breast cancer tissue slices as a model for evaluation of response to rapamycin

Biomarker Development for the Clinical Activity of the mTOR Inhibitor Everolimus (RAD001): Processes, Limitations, and Further Proposals

(2014) Terence O'Reilly et al.   Translational Oncology

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Regulation of TFEB and V-ATPases by mTORC1

(2011) Samuel Peña-Llopis et al.   EMBO JOURNAL

Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer

(2011) Sampoorna Satheesha et al.   Molecular Cancer

Gene Expression Profile in Response to Doxorubicin-Rapamycin Combined Treatment of HER-2-Overexpressing Human Mammary Epithelial Cell Lines

(2011) A. P. Trape et al.   MOLECULAR CANCER THERAPEUTICS

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Targeting the Phosphatidylinositol 3-Kinase Signaling Pathway in Breast Cancer

(2011) L. F. Hernandez-Aya et al.   ONCOLOGIST

Oncogene Activation Induces Metabolic Transformation Resulting in Insulin-Independence in Human Breast Cancer Cells

(2011) Aliccia Bollig-Fischer et al.   PLoS One

Gene expression profiling of response to mTOR inhibitor everolimus in pre-operatively treated post-menopausal women with oestrogen receptor-positive breast cancer

(2010) Vicky S. Sabine et al.   BREAST CANCER RESEARCH AND TREATMENT

The mammalian target of rapamycin inhibitor everolimus (RAD001) in early breast cancer: results of a pre-operative study

(2010) E. J. Macaskill et al.   BREAST CANCER RESEARCH AND TREATMENT

Human breast tumor slices: A model for identification of vitamin D regulated genes in the tumor microenvironment

(2010) C. Milani et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors

(2010) V. Vaira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpressing cellular repressor of E1A-stimulated genes protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt

(2009) Jie Deng et al.   APOPTOSIS

Reciprocal changes in gene expression profiles of cocultured breast epithelial cells and primary fibroblasts

(2009) Patricia Bortman Rozenchan et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting the mTOR Signaling Network for Cancer Therapy

(2009) Funda Meric-Bernstam et al.   JOURNAL OF CLINICAL ONCOLOGY

The rapamycin-regulated gene expression signature determines prognosis for breast cancer

(2009) Argun Akcakanat et al.   Molecular Cancer

Dynamic modularity in protein interaction networks predicts breast cancer outcome

(2009) Ian W Taylor et al.   NATURE BIOTECHNOLOGY

Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer

(2008) Henna Heinonen et al.   BMC GENOMICS

A novel tissue-slice culture model for non-malignant human prostate

(2008) M. Bläuer et al.   CELL AND TISSUE RESEARCH

Dose- and Schedule-Dependent Inhibition of the Mammalian Target of Rapamycin Pathway With Everolimus: A Phase I Tumor Pharmacodynamic Study in Patients With Advanced Solid Tumors

(2008) Josep Tabernero et al.   JOURNAL OF CLINICAL ONCOLOGY

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE

Expression patterns and predictive value of phosphorylated AKT in early-stage breast cancer

(2007) F. Andre et al.   ANNALS OF ONCOLOGY

Regulation of macroautophagy by mTOR and Beclin 1 complexes

(2007) Sophie Pattingre et al.   BIOCHIMIE