Article
Biochemistry & Molecular Biology
Qin Li, Hang Yuan, Gang Zhao, Jie Zhang, Siqi Li, Di Gong, Tianyu Feng, Qiming Kou, Qijing Wang, Guanru Wang, Shan Li, Kai Li, Ping Lin
Summary: Breast cancer is the leading cause of cancer-related deaths in women worldwide, and cancer-associated fibroblasts (CAFs) play a critical role in its progression. However, the detailed molecular mechanisms of CAF activation are still unclear. This study found that loss of ZNF32 promotes the activation of CAFs, leading to increased growth and metastasis of breast cancer cells. Mechanistically, ZNF32 inhibits TGFB1 transcription, preventing fibroblast activation. This study implicates ZNF32 as a potential therapeutic target against breast cancer.
Article
Oncology
Laura Gomez-Cuadrado, Esme Bullock, Zeanap Mabruk, Hong Zhao, Margarita Souleimanova, Pernille Rimmer Noer, Arran K. Turnbull, Claus Oxvig, Nicholas Bertos, Adam Byron, J. Michael Dixon, Morag Park, Syed Haider, Rachael Natrajan, Andrew H. Sims, Valerie G. Brunton
Summary: This study demonstrates the molecular differences in the tumor microenvironment (TME) between invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC), identifying differences in matrix organization and growth factor signaling pathways. These differences are associated with the long-term survival outcomes in ILC.
Article
Cell Biology
Ziqian Yan, Zhimei Sheng, Yuanhang Zheng, Ruijun Feng, Qinpei Xiao, Lihong Shi, Hongli Li, Chonggao Yin, Hao Luo, Chong Hao, Wenhao Wang, Baogang Zhang
Summary: Studies compared the effects of CAFs-derived exosomes and NFs-derived exosomes on breast cancer cells, finding that CAFs-derived exosomes had a stronger enhancing effect on migration and invasion.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Seol Hwa Jo, Woo Hang Heo, Hye-Youn Son, Mingji Quan, Bok Sil Hong, Ju Hee Kim, Han-Byoel Lee, Wonshik Han, Yeonju Park, Dong-Sup Lee, Nam Hoon Kwon, Min Chul Park, Jeesoo Chae, Jong-Il Kim, Dong-Young Noh, Hyeong-Gon Moon
Summary: The direct co-culture of breast cancer cells with non-tumorigenic mammary epithelial cells leads to substantial changes in the molecular and functional characteristics of the mammary epithelial cells, with enhanced proliferation, migration, colony formation, and sphere formation capabilities. Dysregulation of cancer-related pathways is observed, along with upregulation of S100A8 and S100A9, suggesting a potential transition program mediated by these proteins in non-tumorigenic epithelial cells.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Lea Monteran, Nour Ershaid, Hila Doron, Yael Zait, Ye'ela Scharff, Shahar Ben-Yosef, Camila Avivi, Iris Barshack, Amir Sonnenblick, Neta Erez
Summary: This study found that systemic treatment with doxorubicin following resection of triple-negative breast tumors induces the expression of complement factors in lung fibroblasts and modulates an immunosuppressive metastatic niche, thus promoting lung metastasis. Targeting complement signaling with pharmacological treatment can alleviate immune dysregulation and reduce lung metastasis.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Ting Huang, Cheng Lu, Ying Zhang, Bi-yun Lin, Zhe-jun Zhang, Di Zhu, Liang Wang, Yuanzhi Lu
Summary: This study found that CAFs play a crucial role in the tumor microenvironment and are associated with the prognosis of breast cancer patients. High TNC expression is correlated with adverse clinical features and reduced metastasis-free survival.
ANNALS OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Eiman Elwakeel, Andreas Weigert
Summary: Activation of the tumor-associated stroma and the role of cancer-associated fibroblasts (CAFs) in shaping tumor development are crucial in breast cancer. Understanding the multiple functions of CAFs and developing intervention strategies are important for improving breast cancer therapy. Further research is needed to identify specific subsets of CAFs that can be targeted for therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Fang Zheng, Yujia Luo, Yuanqi Liu, Yuanyuan Gao, Wenyu Chen, Kun Wei
Summary: Cancer-associated fibroblasts (CAFs) have a significant role in the tumor microenvironment (TME), and combination therapy using chemotherapeutic agents and TME modulators is a promising approach for cancer treatment. In this study, a TME-based nanoparticle loaded with baicalein was developed to improve the TME in triple-negative breast cancer. The results showed that the nanoparticle inhibited the TGF-β signaling pathway to prevent CAF activation, influencing the tumor stromal microenvironment. Additionally, it increased infiltration of cytotoxic T cells and activated the tumor immune microenvironment. In a murine breast cancer model, the combination of the nanoparticle with doxorubicin nanoparticles significantly improved antitumor effectiveness. These findings suggest that baicalein encapsulated in nanoparticles could be a promising strategy for TME modulation and adjuvant chemotherapy, enhancing the efficacy of nanotherapeutics.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Oncology
Ana Maia, Zuguang Gu, Andre Koch, Mireia Berdiel-Acer, Rainer Will, Matthias Schlesner, Stefan Wiemann
Summary: Chemotherapy is the standard treatment for aggressive tumors like breast cancer, involving cycles of cytotoxic drug administration. Tumor microenvironment plays a role in cancer cell recovery after chemotherapy, where interferon beta 1 from cancer cells triggers an anti-viral state in stromal fibroblasts. This communication leads to CTX resistance and poor response to treatment in breast cancer patients, highlighting the importance of targeting this communication axis to improve outcomes.
MOLECULAR ONCOLOGY
(2021)
Review
Oncology
Yi Li, Changyuan Wang, Ting Huang, Xijie Yu, Bole Tian
Summary: Breast cancer deaths are primarily caused by metastasis. There are several treatment options, but limited options for preventing or inhibiting breast tumor metastases. Studies have focused on the importance of the tumor microenvironment (TME) in metastasis of breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Marika Musielak, Oliwia Piwocka, Katarzyna Kulcenty, Karolina Ampula, Beata Adamczyk, Igor Piotrowski, Magdalena Fundowicz, Marta Kruszyna-Mochalska, Wiktoria M. Suchorska, Julian Malicki
Summary: Cancer-associated fibroblasts (CAFs) are a heterogeneous group of cells with unclear classification and expression patterns. Further research involving more CAF cell lines is needed to understand their characteristics and interactions with breast cancer cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Physiology
Giulia Biffi, David A. Tuveson
Summary: Efforts to develop anti-cancer therapies have mainly targeted the epithelial compartment, but recent studies have shown the significant influence of cancer-associated fibroblasts (CAFs) in tumor progression. CAFs not only promote cancer cell proliferation, therapy resistance, and immune exclusion, but may also restrain tumor progression in certain contexts. Research on CAFs has focused on their heterogeneity, plasticity, and functions across different cancer types and states, as well as advancements in therapeutic strategies targeting CAFs currently undergoing preclinical and clinical evaluation.
PHYSIOLOGICAL REVIEWS
(2021)
Review
Oncology
Dengdi Hu, Zhaoqing Li, Bin Zheng, Xixi Lin, Yuehong Pan, Peirong Gong, Wenying Zhuo, Yujie Hu, Cong Chen, Lini Chen, Jichun Zhou, Linbo Wang
Summary: The tumor microenvironment plays a crucial role in cancer progression, including breast cancer. Cancer-associated fibroblasts (CAFs) are the most abundant components of the tumor microenvironment, promoting breast cancer malignancy through various mechanisms. CAFs have become therapeutic targets due to their unique distribution and biomarkers in tumors. Drugs interrupting the effects of CAFs on surrounding cells have been developed and applied in clinical trials. Summarizing CAF-related studies from a historical perspective can help accelerate the development of CAF-targeted therapeutic strategies for breast cancer.
CANCER COMMUNICATIONS
(2022)
Article
Oncology
Yu Koyama, Hiroya Okazaki, Yang Shi, Yoshihiro Mezawa, Zixu Wang, Mizuki Sakimoto, Akane Ishizuka, Yasuhiko Ito, Takumi Koyama, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Keisuke Sugahara, Okio Hino, Liying Yang, Reo Maruyama, Akira Katakura, Takehiro Yasukawa, Akira Orimo
Summary: Cancer-associated fibroblasts (CAFs) promote tumor growth in human breast cancers. RUNX3 expression is higher in CAFs from cancerous regions compared to non-cancerous regions in breast cancer patients. Knockdown of RUNX3 in CAFs attenuates tumor growth and reduces cancer cell proliferation and microvessel formation.
Article
Medicine, Research & Experimental
Katayoon Pakravan, Majid Mossahebi-Mohammadi, Mohammad H. H. Ghazimoradi, William C. C. Cho, Majid Sadeghizadeh, Sadegh Babashah
Summary: This study investigated the role of cancer-associated fibroblasts (CAFs) in promoting breast cancer (BC) cell progression. The researchers found that CAFs recruited monocytes and induced the formation of pro-tumoral macrophages. Moreover, CAFs were also able to differentiate human monocytes into anti-inflammatory macrophages and increase reactive oxygen species (ROS) generation, which is required for proper macrophage polarization. Importantly, CAF-educated monocytes and their exosomes suppressed T-cell proliferation and promoted BC cell proliferation and migration. In addition, the authors observed an up-regulation of miR-181a in BC, which was positively correlated with tumor aggressiveness. They further demonstrated that miR-181a transfer from CAF-educated monocytes to BC cells through exosomes activated the AKT signaling pathway. These findings highlight the important role of CAFs in tumor progression and provide a potential therapeutic target for BC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Gabriel B. Polho, Giancarlo M. Cardillo, Daniel S. Kerr, Thais Chile, Wagner F. Gattaz, Orestes V. Forlenza, Helena P. Brentani, Vanessa J. De-Paula
Summary: Haloperidol and aripiprazole can reduce telomere damage induced by oxidative stress.
NEURAL REGENERATION RESEARCH
(2022)
Article
Oncology
Elizabeth Santana dos Santos, Amanda B. Spurdle, Dirce M. Carraro, Adrien Briaux, Melissa Southey, Giovana Torrezan, Ambre Petitalot, Raphael Leman, Philippe Lafitte, Didier Meseure, Keltouma Driouch, Lucy Side, Carole Brewer, Sarah Beck, Athalie Melville, Alison Callaway, Francoise Revillion, Maria A. A. Koike Folgueira, Michael T. Parsons, Heather Thorne, Anne Vincent-Salomon, Dominique Stoppa-Lyonnet, Ivan Bieche, Sandrine M. Caputo, Etienne Rouleau
Summary: At least 10% of BRCA1/2 tests result in variants of uncertain significance (VUS), making it challenging to distinguish pathogenic variants (PV) from benign variants (BV). Loss of heterozygosity (LOH) is the most common mechanism for BRCA1 biallelic inactivation, and can be an effective predictor of BRCA1 variant pathogenicity. LOH data is a useful complementary argument for BRCA1 variant classification, with a relatively stable pattern observed in PV tumors.
Letter
Clinical Neurology
Ediel Valerio, Joao Victor Alves de Castro, Dirce Maria Carraro, Giovana Tardin Torrezan, Leslie Domenici Kulikowski, Felipe D'Almeida Costa
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Veronica L. V. Euclydes, Vinicius D. Gastaldi, Arthur S. Feltrin, Daniel J. Hoffman, Gisele Gouveia, Hugo Cogo, Aloisio Felipe-Silva, Rossana P. Vieira, Euripedes C. Miguel, Guilherme Polanczyk, Anna Chiesa, Lislaine Fracolli, Alicia Matijasevich, Alexandre Ferraro, Adriana Argeu, Mariana Maschietto, Helena P. Brentani
Summary: The study found that the interaction between maternal stress exposure and fetal development may be mediated by epigenetic mechanisms, specifically DNA methylation. Analysis of cord blood samples revealed differences in age acceleration and cognitive outcomes between the intervention and control groups. Further analysis showed that specific differentially methylated positions and regions mediated the association between the intervention and cognitive outcomes.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2022)
Article
Oncology
Andrea Sabina Llera, Eliana Saul Furquim Werneck Abdelhay, Nora Artagaveytia, Adrian Daneri-Navarro, Bettina Muller, Carlos Velazquez, Elsa B. Alcoba, Isabel Alonso, Daniela B. Alves da Quinta, Renata Binato, Alicia Ines Bravo, Natalia Camejo, Dirce Maria Carraro, Monica Castro, Juan M. Castro-Cervantes, Sandra Cataldi, Alfonso Cayota, Mauricio Cerda, Alicia Colombo, Susanne Crocamo, Alicia Del Toro-Arreola, Raul Delgadillo-Cisterna, Lucia Delgado, Marisa Dreyer-Breitenbach, Laura Fejerman, Elmer A. Fernandez, Jorge Fernandez, Wanda Fernandez, Ramon A. Franco-Topete, Carolina Gabay, Fancy Gaete, Adriana Garibay-Escobar, Jorge Gomez, Gonzalo Greif, Thomas G. Gross, Marisol Guerrero, Marianne K. Henderson, Miguel E. Lopez-Munoz, Alejandra Lopez-Vazquez, Silvina Maldonado, Andres J. Moran-Mendoza, Maria Aparecida Nagai, Antonio Oceguera-Villanueva, Miguel A. Ortiz-Martinez, Jael Quintero, Antonio Quintero-Ramos, Rui M. Reis, Javier Retamales, Ernesto Rivera-Claisse, Dario Rocha, Robinson Rodriguez, Cristina Rosales, Efrain Salas-Gonzalez, Veronica Sanchotena, Laura Segovia, Juan Martin Sendoya, Aida A. Silva-Garcia, Alejandra Trinchero, Olivia Valenzuela, Vidya Vedham, Livia Zagame, Osvaldo L. Podhajcer
Summary: This study assessed molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways were found to be the main tumor-driving mechanisms and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America.
FRONTIERS IN ONCOLOGY
(2022)
Article
Developmental Biology
Kyle S. Wiley, Caroline Camilo, Gisele Gouveia, Veronica Euclydes, Catherine Panter-Brick, Alicia Matijasevich, Alexandre Archanjo Ferraro, Lislaine Aparecida Fracolli, Anna Maria Chiesa, Euripedes Constantino Miguel, Guilherme V. Polanczyk, Helena Brentani
Summary: Maternal prenatal psychosocial stress is associated with altered hypothalamic-pituitary-adrenal axis (HPAA) function among infants. This study found that altered DNA methylation, specifically in the oxytocin receptor gene, may contribute to the regulation of HPAA during infancy. Maternal distress and anxiety symptoms were negatively associated with DNA methylation and cortisol levels in infants.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Article
Immunology
Ananda D. Lopes, Nayane A. L. Galdino, Amanda B. Figueiredo, Rafael C. Brianese, Katia L. P. Morais, Marina De Brot, Cynthia A. B. T. Osorio, Andrea Teixeira-Carvalho, Vinicius F. Calsavara, Guilherme F. B. Evangelista, Natalia S. Alves, Fabiana B. Makdissi, Solange M. Sanches, Vladmir C. Cordeiro de Lima, Dirce M. Carraro, Kenneth J. Gollob
Summary: Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer, and neoadjuvant chemotherapy has proven efficacy in its treatment. This study found that elevated levels of immune mediators before treatment were associated with a higher likelihood of achieving a pathological complete response (pCR), as well as a positive correlation with tumor-infiltrating lymphocytes (TILs) in pCR responder patients. Combining TILs and systemic immune mediator levels improved the predictive value of pCR. Furthermore, circulating cytokines may act as a surrogate marker for high TILs and predict survival.
Article
Biochemistry & Molecular Biology
Banny Silva Barbosa Correia, Joao Guilherme de Moraes Pontes, Joao Victor Silva Nani, Fabian Villalta, Natalia Cristina Mor, Daniela Bordini, Decio Brunoni, Helena Brentani, Jair Jesus Mari, Mirian A. F. Hayashi, Ljubica Tasic
Summary: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social communication, interactions, and restricted repetitive behavior. Video modeling for parental training has been proven to be a successful low-cost intervention for children with ASD. Metabolomics and lipidomics analysis using proton NMR spectroscopy showed significant changes in serum metabolites and lipids in ASD children who received parental training, indicating the potential of using these approaches as biomarkers for clinical interventions in ASD.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Pathology
Sara Iolanda Oliveira da Silva, Tabata Alves Domingos, Bruna Elisa Catin Kupper, Louise De Brot, Samuel Aguiar Junior, Dirce Maria Carraro, Giovana Tardin Torrezan
Summary: We developed a test for assessing MLH1 promoter methylation based on NGS and evaluated its concordance with BRAF mutation status in CRC. Our results showed a high concordance between MLH1 methylation and BRAF mutation in MLH1/PMS2 deficient tumors, indicating that this NGS test could be used to identify sporadic causes of MLH1/PMS2 deficiency in CRC.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2023)
Article
Genetics & Heredity
Bethany Vibert, Patricia Segura, Louise Gallagher, Stelios Georgiades, Panagiota Pervanidou, Audrey Thurm, Lindsay Alexander, Evdokia Anagnostou, Yuta Aoki, Catherine S. Birken, Somer L. Bishop, Jessica Boi, Carmela Bravaccio, Helena Brentani, Paola Canevini, Alessandra Carta, Alice Charach, Antonella Costantino, Katherine T. Cost, Elaine A. Cravo, Jennifer Crosbie, Chiara Davico, Federica Donno, Junya Fujino, Alessandra Gabellone, Cristiane T. Geyer, Tomoya Hirota, Stephen Kanne, Makiko Kawashima, Elizabeth Kelley, Hosanna Kim, Young Shin Kim, So Hyun Kim, Daphne J. Korczak, Meng-Chuan Lai, Lucia Margari, Lucia Marzulli, Gabriele Masi, Luigi Mazzone, Jane McGrath, Suneeta Monga, Paola Morosini, Shinichiro Nakajima, Antonio Narzisi, Rob Nicolson, Aki Nikolaidis, Yoshihiro Noda, Kerri Nowell, Miriam Polizzi, Joana Portolese, Maria Pia Riccio, Manabu Saito, Ida Schwartz, Anish K. Simhal, Martina Siracusano, Stefano Sotgiu, Jacob Stroud, Fernando Sumiya, Yoshiyuki Tachibana, Nicole Takahashi, Riina Takahashi, Hiroki Tamon, Raffaella Tancredi, Benedetto Vitiello, Alessandro Zuddas, Bennett Leventhal, Kathleen Merikangas, Michael P. Milham, Adriana Di Martino
Summary: The study examined the impact of the COVID-19 pandemic on youth with autism spectrum disorder and related neurodevelopmental disorders, revealing heterogeneity in symptoms and access to services. The findings can inform recovery efforts and emphasize the importance of international data-sharing and collaborations in addressing the needs of vulnerable populations during crises.
Article
Oncology
Marcelo Moreno, Julia Salles Oliveira, Rafael Canfield Brianese, Douglas Guedes de Castro, Solange Moraes Sanches, Giovana Tardin Torrezan, Karina Miranda Santiago, Marina De Brot, Vladmir Claudio Cordeiro de Lima, Fabiana Baroni Alves Makdissi, Jose Claudio Casali Da Rocha, Vinicius Fernando Calsavara, Dirce Maria Carraro
Summary: By analyzing the data of TNBC patients treated at the A.C. Camargo Cancer Center from 1998 to 2020, it was found that TNBC patients with BRCA2 gene PV were more likely to develop bone and central nervous system metastases during the course of the disease. However, BRCA2 gene PV was not an independent predictor of metastases and overall survival. Therefore, increasing the number of BRCA2 carriers among TNBC patients is crucial for determining their risk of developing bone and central nervous system metastases compared to non-carriers.
Review
Multidisciplinary Sciences
Fabio Rosindo Daher de Barros, Caio Novais F. da Silva, Gabriel de Castro Michelassi, Helena Brentani, Fatima L. S. Nunes, Ariane Machado-Lima
Summary: Facial image analysis using image processing and machine learning techniques can help diagnose genetic syndromes and neurodevelopmental disorders. These systems offer faster and cost-effective alternatives for genotyping tests, especially for large-scale applications. However, ensuring the accuracy and reliability of computer-aided diagnosis systems remains a challenge.
Article
Oncology
Pal Moller, Toni Seppala, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann, Elizabeth Half, Francisco Lopez-Koestner, Karin Alvarez-Valenzuela, Rodney J. Scott, Lior Katz, Ido Laish, Elez Vainer, Carlos Alberto Vaccaro, Dirce Maria Carraro, Nathan Gluck, Naim Abu-Freha, Aine Stakelum, Rory Kennelly, Des Winter, Benedito Mauro Rossi, Marc Greenblatt, Mabel Bohorquez, Harsh Sheth, Maria Grazia Tibiletti, Leonardo S. Lino-Silva, Karoline Horisberger, Carmen Portenkirchner, Ivana Nascimento, Norma Teresa Rossi, Leandro Apolinario da Silva, Huw Thomas, Attila Zarand, Jukka-Pekka Mecklin, Kirsi Pylvanainen, Laura Renkonen-Sinisalo, Anna Lepisto, Paivi Peltomaki, Christina Therkildsen, Lars Joachim Lindberg, Ole Thorlacius-Ussing, Magnus von Knebel Doeberitz, Markus Loeffler, Nils Rahner, Verena Steinke-Lange, Wolff Schmiegel, Deepak Vangala, Claudia Perne, Robert Hueneburg, Aida Falcon de Vargas, Andrew Latchford, Anne-Marie Gerdes, Ann-Sofie Backman, Carmen Guillen-Ponce, Carrie Snyder, Charlotte K. Lautrup, David Amor, Edenir Palmero, Elena Stoffel, Floor Duijkers, Michael J. Hall, Heather Hampel, Heinric Williams, Henrik Okkels, Jan Lubinski, Jeanette Reece, Joanne Ngeow, Jose G. Guillem, Julie Arnold, Karin Wadt, Kevin Monahan, Leigha Senter, Lene J. Rasmussen, Liselotte P. van Hest, Luigi Ricciardiello, Maija R. J. Kohonen-Corish, Marjolijn J. L. Ligtenberg, Melissa Southey, Melyssa Aronson, Mohd N. Zahary, N. Jewel Samadder, Nicola Poplawski, Nicoline Hoogerbrugge, Patrick J. Morrison, Paul James, Grant Lee, Rakefet Chen-Shtoyerman, Ravindran Ankathil, Rish Pai, Robyn Ward, Susan Parry, Tadeusz Debniak, Thomas John, Thomas van Overeem Hansen, Trinidad Caldes, Tatsuro Yamaguchi, Veronica Barca-Tierno, Pilar Garre, Giulia Martina Cavestro, Juergen Weitz, Silke Redler, Reinhard Buettner, VincentZ Heuveline, John L. Hopper, Aung Ko Win, Noralane Lindor, Steven Gallinger, Loic Le Marchand, Polly A. Newcomb, Jane Figueiredo, Daniel D. Buchanan, Stephen N. Thibodeau, Sanne W. ten Broeke, Eivind Hovig, Sigve Nakken, Marta Pineda, Nuria Duenas, Joan Brunet, Kate Green, Fiona Lalloo, Katie Newton, Emma J. Crosbie, Miriam Mints, Douglas Tjandra, Florencia Neffa, Patricia Esperon, Revital Kariv, Guy Rosner, Walter Hernan Pavicic, Pablo Kalfayan, Giovana Tardin Torrezan, Thiago Bassaneze, Claudia Martin, Gabriela Moslein, Aysel Ahadova, Matthias Kloor, Julian R. Sampson, Mark A. Jenkins
Summary: This study compared the colorectal cancer incidence in carriers of pathogenic variants of the MMR genes in two cohorts. The PLSD cohort, with mandatory colonoscopy surveillance, had higher CRC incidences compared to the retrospective IMRC cohort. Surprisingly, the incidence was not reduced in path_MSH6 carriers. However, the incidence in path_PMS2 carriers was reduced, though not significantly.
HEREDITARY CANCER IN CLINICAL PRACTICE
(2022)
Article
Dermatology
Ricardo Hsieh, Marcello M. S. Nico, Claudia M. C. Camillo, Katia K. Oliveira, Dirce M. Carraro, Martin Sangueza, Silvia Lourenco
Summary: This study analyzed somatic mutations in sun-protected melanomas and identified new actionable mutations that could be potential targets for treatment. Further research on other subtypes of melanoma may confirm these findings and discover new mutations.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)
Article
Computer Science, Information Systems
Daniel G. P. Petrini, Carlos Shimizu, Rosimeire A. Roela, Gabriel Vansuita Valente, Maria Aparecida Azevedo Koike Folgueira, Hae Yong Kim
Summary: Recent studies have demonstrated the effectiveness of deep convolutional neural networks in diagnosing breast cancer in mammograms, achieving remarkable results with a two-view classifier obtained through multiple transfer learning processes.
