Editorial Material
Primary Health Care
Saba Fatima
Summary: In medical training, maintaining boundaries with patients is important, but excessive distance can lead to a lack of meaningful patient relationships and burnout. Listening to patient stories can provide purpose and gratitude in medicine, but also comes with the vulnerability to pain and loss.
ANNALS OF FAMILY MEDICINE
(2022)
Article
Robotics
Antoine Richard, Stephanie Aravecchia, Thomas Schillaci, Matthieu Geist, Cedric Pradalier
Summary: This letter demonstrates using Deep RL and Domain Randomization to successfully solve a navigation task in a natural environment, showing the model's ability to adapt and perform well without real world training. Additionally, the RL agent is proven to be more robust, faster, and more accurate compared to other methods.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Heejin Kim, Kyuha Choi
Summary: During meiosis, genetic recombination plays a vital role in generating genetic variation and affecting breeding outcomes. However, the frequency and distribution of crossovers (COs) in plants are controlled by various factors. Accurate detection of COs is crucial for understanding meiosis and chromosome behavior.
MOLECULES AND CELLS
(2022)
Article
Biochemical Research Methods
Marius Pachitariu, Carsen Stringer
Summary: This study introduces Cellpose 2.0, a software package that includes diverse pretrained models and a human-in-the-loop pipeline for rapid customization of models. The results show that models pretrained on the Cellpose dataset can be fine-tuned with fewer user annotations and still achieve high-quality segmentations.
Editorial Material
Multidisciplinary Sciences
Rachel Brazil
Summary: The immune system shows a stronger response to previously encountered virus strains, which weakens its response to other strains. Can this 'imprinting' effect be overcome?
Editorial Material
Chemistry, Multidisciplinary
Elba Feo, Sofia Olendraru, Michael O'Neill, Charlie H. Simms
Summary: Periods can hinder academic progress, especially in physically intensive courses. Improving the environment for people with periods by providing free period products in educational institution bathrooms is a practical way to reduce barriers in studying chemistry.
TRENDS IN CHEMISTRY
(2023)
Article
Computer Science, Artificial Intelligence
Alina Kloss, Georg Martius, Jeannette Bohg
Summary: This work investigates the advantages of differentiable filters (DFs) over other learning approaches, provides practical guidance, and compares DFs with various underlying filtering algorithms through extensive experiments.
Article
Environmental Sciences
Ronald A. Hites
Summary: After finishing writing a scientific paper, submitting it to a peer-reviewed journal and dealing with editors is crucial. The author provides advice on how to navigate the peer-review system and interact with editors based on personal experience.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Editorial Material
Cell Biology
Martin Farley
Summary: Scientific research is important for understanding the world, but its resource intensity is damaging. To move towards a more sustainable model, actions should be taken to make it more reproducible, eco-friendly, and cost-effective.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Education & Educational Research
Nana Ariel, Maaian Millikovsky-Ayalon, Omri Kimchi Feldhorn
Summary: This study presents a redesign process for a successful MOOC course, based on learning-science principles. The course not only teaches about learning, but also practices effective learning experiences. The redesign addresses issues in online learning and provides a model for digital learning in other areas.
EDUCATION AND INFORMATION TECHNOLOGIES
(2023)
Article
Neurosciences
Javier Gonzalez-Castillo, Julia W. Y. Kam, Colin W. Hoy, Peter A. Bandettini
Summary: Resting-state fMRI reveals brain dynamics in an unconstrained environment where subjects let their minds wander freely, navigating a rich space of cognitive and perceptual states. How ongoing experience influences rsfMRI summary metrics is unclear, but may uniquely contribute to differences within and between subjects. To understand this influence, standardized, temporally resolved, scientifically validated first-person descriptions of experiences are necessary.
JOURNAL OF NEUROSCIENCE
(2021)
Editorial Material
Ecology
Christina A. A. Del Carpio, Ashlyn T. T. Ford, Eva S. Horna Lowell, Marissa E. E. Ochoa, Hayden P. P. Speck
Summary: Seminar series play a crucial role in academic culture. We propose strategies to enhance diversity of seminar speakers, aiming to provide more opportunities for members in the field of ecology and evolutionary biology research.
NATURE ECOLOGY & EVOLUTION
(2023)
Editorial Material
Biology
Eve Marder
Summary: Changes in science have diminished the opportunities for trainees to experience the joy of discovery over the past 50 years.
Article
Environmental Sciences
Caner Baydur, Baojing Pu, Xiaoqing Xu
Summary: Designing blinds with proper acoustic design is crucial for wildlife photographers to get close to birds. This study introduces noise-cancelling blinds that enable close-range bird photography. The research includes a questionnaire to determine birders' expectations of the sound environment and examines the impact of architectural and acoustic decisions on noise propagation. The study also tests the acoustic performances of the blinds based on the birds' hearing threshold using numerical simulations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Jose M. Ramia
Summary: Publication in a peer-reviewed journal is the ultimate goal of research projects. However, choosing a suitable journal that is likely to accept your work is often overlooked. This editorial provides detailed information and tips for success in this crucial aspect of the publication process.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Cell Biology
Mehmet E. Karasu, Nora Bouftas, Scott Keeney, Katja Wassmann
JOURNAL OF CELL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Cynthia Petrillo, Vilma Barroca, Jonathan Ribeiro, Nathalie Lailler, Gabriel Livera, Scott Keeney, Emmanuelle Martini, Devanshi Jain
Article
Cell Biology
Shintaro Yamada, Anjali Gupta Hinch, Hisashi Kamido, Yongwei Zhang, Winfried Edelmann, Scott Keeney
GENES & DEVELOPMENT
(2020)
Article
Multidisciplinary Sciences
Hajime Murakami, Isabel Lam, Pei-Ching Huang, Jacquelyn Song, Megan van Overbeek, Scott Keeney
Article
Biochemistry & Molecular Biology
Anjali Gupta Hinch, Philipp W. Becker, Tao Li, Daniela Moralli, Gang Zhang, Clare Bycroft, Catherine Green, Scott Keeney, Qinghua Shi, Benjamin Davies, Peter Donnelly
Article
Biochemistry & Molecular Biology
Corentin Claeys Bouuaert, Sam E. Tischfield, Stephen Pu, Eleni P. Mimitou, Ernesto Arias-Palomo, James M. Berger, Scott Keeney
Summary: The study provides molecular analysis of the Saccharomyces cerevisiae Spo11 core complex and reveals structural and functional similarities with ancestral Topo VI. The Spo11 complex is found to be monomeric and exhibits topoisomerase-like DNA binding preferences, showing high affinity for DNA ends mimicking cleavage products. Mutations that reduce DNA binding in vitro lead to attenuated DSB formation and alterations in DSB processing and landscape in vivo.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2021)
Review
Genetics & Heredity
Hajime Murakami, Xiaojing Mu, Scott Keeney
Summary: The study shows that in budding yeast, the programmed formation of DNA double-strand breaks in meiotic prophase I is achieved through the targeted binding of DSB proteins on short chromosomes. This preferential binding is promoted by intrinsic features independent of the meiosis-specific cohesin subunit Rec8 and DNA replication.
Article
Genetics & Heredity
Yongjuan Guan, Scott Keeney, Devanshi Jain, P. Jeremy Wang
Summary: Piwi-interacting RNAs (piRNAs) are crucial for germline genome integrity and spermiogenic differentiation. MOV10L1, a germ-cell-specific RNA helicase, is essential for the production of both pre-pachytene and pachytene piRNAs. A novel Mov10l1 mutation, yama, with a single amino acid substitution V229E, causes meiotic arrest, de-repression of transposable elements, and male sterility due to defects in pre-pachytene piRNA biogenesis.
Article
Multidisciplinary Sciences
Corentin Claeys Bouuaert, Stephen Pu, Juncheng Wang, Cedric Oger, Dima Daccache, Wei Xie, Dinshaw J. Patel, Scott Keeney
Summary: This study elucidates how Saccharomyces cerevisiae RMM proteins self-assemble on chromosome axes to create centers of DSB activity. Protein-DNA interactions drive condensation and recruitment of Spo11 complexes, highlighting the multilayered control of Spo11 in chromosome segregation.
Article
Multidisciplinary Sciences
Dominic Johnson, Margaret Crawford, Tim Cooper, Corentin Claeys Bouuaert, Scott Keeney, Bertrand Llorente, Valerie Garcia, Matthew J. Neale
Summary: Genetic recombination during meiosis involves the repair of DNA double-strand breaks (DSBs) created by Spo11, with recent findings indicating the existence of multiple Spo11 DSBs termed 'double cuts'. These double cuts vary in length with a periodicity of 10.5 base pairs and play a role in recombination and DNA gap repair during meiosis.
Article
Biochemistry & Molecular Biology
Agnieszka Lukaszewicz, Julian Lange, Scott Keeney, Maria Jasin
Summary: Numerous DNA double-strand breaks arise during meiosis to initiate homologous recombination. A distinct type of mutational event involves deletions formed by joining ends from closely spaced DSBs within single or adjacent hotspots. In the absence of the ATM kinase, these deletions are more frequent and may lead to insertional mutagenesis.
Article
Cell Biology
Yuhki Saito, Ben R. Hawley, M. Rhyan Puno, Shreya N. Sarathy, Christopher D. Lima, Samie R. Jaffrey, Robert B. Darnell, Scott Keeney, Devanshi Jain
Summary: In this study, the researchers investigated how the N-6-methyladenosine (m(6)A) reader and RNA helicase YTHDC2 regulate gene expression during meiosis. They found that YTHDC2 can bind transcripts independent of m(6)A status and regulate gene expression through distinct mechanisms during multiple stages of meiosis. Mutation of the m(6)A-binding pocket of YTHDC2 had no effect on gametogenesis, suggesting that YTHDC2's function is m(6)A-independent. However, mutation in the ATPase motif of YTHDC2 blocked meiotic prophase I progression, causing sterility.
GENES & DEVELOPMENT
(2022)
Article
Multidisciplinary Sciences
Kaku Maekawa, Shintaro Yamada, Rahul Sharma, Jayanta Chaudhuri, Scott Keeney
Summary: This study demonstrates that the triplex-forming potential of H-DNA motifs in the mouse genome can be evaluated using S1-seq method. Prominent clusters of S1-seq reads that coincide with H-DNA motifs and correlate strongly with the triplex-forming potential were observed in genomic DNA isolated from mouse testis cells and splenic B cells. The study further explores how the structure of H-DNA is modified by polypyrimidine repeat length and the presence of repeat-interrupting substitutions using naturally occurring H-DNA motifs across the mouse genome.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Kaixian Liu, Emily M. Grasso, Stephen Pu, Mengyang Zou, Shixin Liu, David Eliezer, Scott Keeney
Summary: This study reports the structure and dynamic DNA binding properties of the Rec114 and Mei4 protein complex, which initiates DNA double-strand breaks during meiotic recombination. The complex can bridge multiple DNA duplexes and generate force to condense DNA through long-range interactions. These findings provide insight into the conserved networks of protein-protein and protein-DNA interactions that promote condensate formation and meiotic DSBs.
GENES & DEVELOPMENT
(2023)
Article
Cell Biology
Xiaojing Mu, Hajime Murakami, Neeman Mohibullah, Scott Keeney
GENES & DEVELOPMENT
(2020)
