Journal
CATALYSIS LETTERS
Volume 143, Issue 1, Pages 118-121Publisher
SPRINGER
DOI: 10.1007/s10562-012-0920-3
Keywords
Cyclization; Heterocycles; Enzymes; Catalysis; Imidazoles
Categories
Funding
- National Natural Science Foundation of China [21106026]
- Zhejiang Provincial Natural Science Foundation of China [Y4090052]
- Key Sci-tech Innovation Team of Zhejiang Province [2010R50017-7]
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A simple and efficient protocol of synthesizing 2,4,5-trisubstituted imidazoles has been developed using lipase as a novel catalyst under mild conditions. A series of imidazole derivatives were synthesized with good yields. The probable enzymatic mechanism was proposed. This method expands the catalytic scope of lipase and provides a novel method to prepare imidazole derivatives.
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